A short conversational clip (YouTube #shorts) in which an unidentified speaker asks about detecting and optimizing suboptimal hormone function, and Robert Whitfield MD frames the issue in genetic and enzymatic terms — noting inherited genetic variability (examples of incomplete penetrance/variable expressivity) can limit enzymatic capacity to maintain homeostasis, especially under dietary stress.
So we really have this huge opportunity, thanks to the shot and to what everybody is seeing happening as a result of the people who are taking it, to understand what all of us can benefit from, which is how do we actually figure out is there suboptimal function of our own hormones? And how do we then what tools do we use, what processes are involved in optimizing our own? So I'll pause there. Does that track for you, like, kind of in a different way?
Yeah, when I think of it globally, you know, we all talk about enzymatic function. So, you know, basically when you're trying to, you know, have homeostasis in a system, the ability of, or how I think of it is you can't pick your parents and you can't outrun a bad diet. So if genetically you inherit, parents inherit, whether it's a gene that has incomplete penetrance like brca, or if you have a gene inherited that is more of variable expressivity, like Marfan's FNAB1 or something like that. Basically, from my understanding, basically what you're saying is because we have that, and I don't know if you're saying it's a gene specifically because there's probably a number of them involved, one that's got incomplete penetrance or variable expressivity, our capacity is the problem. So if you're eating whatever, so much sugar that you can't handle it, then enzymatically it's incapable of maintaining homeostasis, and then we get what we get out of that. So I always think of it like that, in terms of genetics.
