Robert Whitfield MD explains Alessio Fasano's theory that zonulin, a protein that opens gaps in the gut lining, triggers chronic inflammation. Fasano calls it the perfect storm: you need genetic susceptibility, an environmental trigger, and a leaky gut all at once.
Authors on the paper. And the last name, Alessio Fasano. The boss. Right. The stamp of approval. This paper is ready to go. Well, this paper he wrote himself, which gives you a sense of how important he thinks it is to make sure the message comes across. Right. And. And the title. The title says it all. All disease begins in the quote, leaky gut. The role of the protein zonulin in the development of chronic inflammatory diseases. And he talks about. In that paper, he talks about what he refers to as the perfect storm, where disease comes from. And we're all saying they start all in the gut. That's what Fasano is telling us. And I'm going to go through the perfect storm. That. Okay, can you see my screen now? Yes. Okay. So what is a leaky gut? So, Mrs. Patient, your digestive system is a tube. It goes from the mouth to the other end. It's about 20, 25ft long, winds around in the center there. It's one big long tube. And if you think of it like a donut, if you stretch a donut out, that's your digestive tract.
