Robert Whitfield MD explains how MTHFR gene variants affect vitamin D metabolism and estrogen processing, potentially driving fatigue, PCOS, and endometriosis. About half the population carries MTHFR variants that impair the body's ability to clear toxins and regulate estrogen, he says, linking this to conditions like breast implant illness.
If you have the MTHFR gene, are you more susceptible to breast implant illness, you think? We're in a room right now with everybody doing this show. There's five people. Half of us will have that gene. That is one player. And then how we metabolize vitamin D and absorb it and transport it, how we. Everybody may or may not have heard of something called glutathione, which is an antioxidant. They use it for beauty a lot. They're like, oh, get your glutathione. Push IV at the. You. You know, the. The place. So we use liposomal glutathione as part of our inflammation support bundle. But the point is, that substance incredibly important to bind up and detoxify things in your liver. Okay? So when you have limitations in vitamin D metabolism, methylation, how you metabolize glutathione, and then your antioxidant pathway, everybody remembers antioxidants like vitamin C. All right, so if we have limitations genetically in antioxidant pathways in our cells, we'll have a buildup of products that makes us more and more fatigued. You can just imagine, like somebody. My client is that person who has three or four of those problems. Plus, in general, many of my patients have trouble with estrogen toxicity or just difficulty with estrogen metabolism. Many people listening. I will go on to have problems with PCOS and endometriosis, a lot of which is a genetic predisposition. So if you metabolize estrogen a certain way, instead of making, we'll just call it good estrogen, estrogen, estradiol, you may make a lot more estrone, and that's responsible for problems with your cycle and pain, endometriosis and pcos.
