26yo Turned $250k into $400M | Chad Byers, Co-Founder of Susa Ventures

5 Mar 2026 · 31 min
30:33

In this interview, host Ryan Nisbet talks with Chad Byers, co‑founder of Susa Ventures, about the fund’s early days, its investment philosophy, and the personal principles that guide his decisions. Byers recounts the iconic Robinhood seed investment—$250K that became $400M—highlighting how a beautifully designed beta convinced him despite expert skepticism. He explains Susa’s original “data moat” thesis (data as the new oil) and how it has evolved with AI, while also noting that data moats still exist, especially in proprietary domains like electronic medical records. Byers describes his “spiky” founder evaluation framework, emphasizing outlier intelligence, drive, and deep personal conversations over quick questionnaires. He discusses the tension between fast‑paced deal flow and his preference for long‑term, relationship‑focused investing, sharing anecdotes about early LP rejections, the importance of mission‑aligned LPs (mostly nonprofit healthcare institutions), and the art of winning deals through personal rapport rather than brand alone. The conversation also touches on handling hype, adapting opinions, emerging moats such as execution speed, and future investment themes like longevity drugs, AI‑driven drug discovery, and the broader impact of AI on the real economy. Throughout, Byers stresses conviction, patience, and the value of learning from both successes and failures.

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