Shereene IdrissBoard Certified Derm, Founder and Chief Nerd

Botox To Last Longer? Part 1 #shorts

16 Nov 2023 · 1 min

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YouTube short by a board-certified dermatologist discussing whether zinc can extend the duration of Botox. The speaker explains the mechanistic rationale (Botox is a zinc-dependent metalloprotease) and summarizes existing evidence: two small non-randomized studies and a systematic review, concluding the data are inconclusive and insufficient to recommend zinc.

Chapters

If you're not getting a long duration out of your Botox, listen to this tip take Whoa. Before you go wasting your money on zinc, I'm a board certified dermatologist. Let's understand this so there have been two studies and a systematic review that has been looking at the literature to see if zinc can help increase the effects of Botox. Why? Because Botox is a zinc dependent metalloprotease, so it needs zinc in order to do what it needs to do, which is paralyze your muscle. But the reality is those studies were not really randomized controlled trials and they were not expansive enough. So the number of people in the study was quite small and it's hard to draw conclusive conclusions from those studies.