Brain’s Evolutionary Aversion to Uncertainty
19 Nov 2025 · 1 min

0:41
In this talk, Susan Britton MCC explains that humans have an evolutionary aversion to uncertainty because uncertainty can signal potential threats. The prefrontal cortex (PFC) works overtime—what she calls “overdrive mode”—to try to resolve uncertain situations, whether they involve political instability, a parent’s health, personal medical diagnoses, or launching a new business. By attempting to make the uncertain certain, the brain seeks to restore a sense of safety, calm, and control. The excerpt emphasizes that reducing uncertainty can lead to feeling safer and more at ease.










