These Conditions Are Neurological, Not Psychological

Ashok Gupta argues ME/CFS, fibromyalgia, and related conditions are neurological and immune-based, not psychological. Brain imaging shows insula and prefrontal cortex shrinkage of 5-10%, alongside mitochondrial dysfunction, inflammation, and altered gene expression in 20-30 genes. He calls them neuroimmune conditioned syndromes: nervous system changes that trigger overlapping symptom clusters.
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So I was just talking about the various abnormalities that we found with people who have these conditions. So the mitochondria aren't functioning correctly. We know there's inflammation, there's physiological changes in the structure of the brain. Where we see a shrinkage in the part of the brain called the insula, we see a contraction of the prefrontal cortex, often by 5 to 10%. We see other parts of the brain responding inappropriately or actually shrinking or expanding. So we know that there are those kinds of changes. We know there's a shift in the hypothalamus, pituitary, adrenal gland access, and the way that we respond to stresses. We know the cortisol rhythms are out of whack, we know the sleep rhythms are out of whack. So we even know that gene expression is changed. So there are 20 to 30 genes which respond in a very different way. All of these are clues or actually just pure evidence showing us that it's not in the head, it's not psychological. And I know what it's like when you're having to battle with a medical profession, perhaps battle with people who are providing benefits to you to help them understand this condition better. And unfortunately, the traditional medical profession finds it quite hard to treat these conditions because once again, in traditional medicine, traditional medicine has made in fantastic strides on conditions which work on the reductionist philosophy, which essentially means there's something wrong in the body as if it's a car. So there's something wrong over here. We fix that, everything comes back to normal. There's something wrong over here in the neurons in the brain, right? We fix that, come back to normal. But these conditions, conditions where we need to treat the entire nervous system, the entire software. So medicine is set up to treat the hardware of the body, as it were, but these conditions are issues with the software. So if there's something that goes wrong with the hardware of your computer, you would go and take it in for to a particular computer engineer who would then open it up and fix whatever could be going wrong at a hardware level. But when a software issue happens, what do you need to do? You often need to run an update or reinstall. So, as people know, I'm a bit of an IT geek, so I love all these analogies to do with hardware and software. So the way we treat a hardware issue is very different to the way that we treat a software issue. And I call these conditions neuroimmune conditioned syndromes. Let me explain that. I believe that these conditions are neurological, which Means they involve the nervous system in the brain, they're not in the head, but they are in the brain, in my view, immune. Because most of these conditions involve some kind of abnormal immune reaction. Too many cytokines in the body, conditioned means that it's been trained into the nervous system to respond in a certain way, been trained in the brain to respond in a certain way. And all of this is happening unconsciously, subconsciously, beyond conscious awareness. So how can it be psychological if it's incurring in these unconscious brain structures upon which we normally have no control or very little control? Therefore, it can't even be classed as psychological. Certainly each illness that we encounter, every illness that we encounter has a psychological component. For instance, in cancer treatments, they find that when they do group therapy or meditation or mindfulness, there are certain psychological interventions that support the healing of people with cancer, people with heart disease. So there certainly are psychological interventions that can support the healing of every condition. We know that getting a cold or getting a flu is very much based on your psychological state of mind. However, that doesn't mean that the root cause of these conditions is psychological, but they can be impacted by our psychology, and they are two very different things. So it's talking about neuroimmune condition syndromes. Syndromes means that there's a collection of symptoms based on our unique vulnerability or genetic vulnerability. So, for instance, when we look at ME CFS and fibromyalgia and chemical sensitivities, there's often a crossover between those conditions and people have a certain set of symptoms that perhaps could belong to any of these conditions. And then when we look at chemical sensitivities and mold sensitivity, often they come in hand in hand. We look at food sensitivities as well. They're often part of the package. And there are various other related conditions, like POTs, such as autonomic dysfunction syndrome, chronic pain syndromes. All of these various conditions all seem to have overlaps. And we're trying to understand what exactly is the core of it. And I believe that the core of it is an overstimulation of the brain, of the nervous system and the immune system, causing a unique pattern of.










