Akkermansia and Metformin: Benefits

Name: Akkermansia and Metformin: Benefits
Uploaded: 2024-06-14T16:00:11+00:00
Duration: 32 s
Channel: Dr. Charles Mok
Description: This content was created by Dr. Charles Mok. This content was uploaded by Dr. Charles Mok. This is a YouTube video titled "Akkermansia and Metformin…

14 Jun 2024 · 1 min

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This content was created by Dr. Charles Mok. This content was uploaded by Dr. Charles Mok. This is a YouTube video titled "Akkermansia and Metformin: Benefits" (created 2024-06-14) featuring a single speaker (labeled SPEAKER A) discussing gut microbiome and metabolic health. The speaker reports a stool test showing good levels of Akkermansia, notes that low Akkermansia is associated with overweight, and that Akkermansia supports brain health. They explain that intermittent, low-dose Akkermansia can raise GLP-1 levels in the gut; that metformin also raises GLP-1 by decreasing its degradation; and that GLP-1 is the target of semaglutide, so metformin can be used synergistically with semaglutide. The speaker also cautions against initiating semaglutide and metformin at the same time because both can cause gastrointestinal side effects.

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I did the stool test and I do have good Akkermansia in my body. People overweight tend to have low Akkermansia, but also Akkermansia is supportive for brain health, so I'm taking that too. Not for the same reason. In a lower dose and just intermittently, akkermansia can raise GLP1 level in the gut. Metformin raises GLP1 level by decreasing its degradation. Again, GLP1 is a target of the semaglutide, and it can be taken synergistically with semaglutide. We generally don't start semaglutide and metformin at the onset because both of them have the possibility of gastrointestinal side effects.