Bioidentical vs Synthetic Hormones

Name: Bioidentical vs Synthetic Hormones
Uploaded: 2025-06-25T22:30:12+00:00
Duration: 49 s
Channel: Dr. Charles Mok
Description: Dr. Charles Mok explains why bioidentical hormones like progesterone and estradiol work better than synthetic alternatives for hormone replacement…

25 Jun 2025 · 1 min

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Dr. Charles Mok explains why bioidentical hormones like progesterone and estradiol work better than synthetic alternatives for hormone replacement therapy. He recommends Prometrium for progesterone, describes a weight-based dosing approach for testosterone, and notes that oral progesterone at 100-200 mg at night can help with sleep.

Questions this video answers

Prometrium

No — the speaker states there is no FDA-approved commercially available testosterone for women.

Weight-based: typically one milligram per pound of body weight.

About 1/20th of the testosterone dose (example given: ~6 mg estrogen).

Approximately 100–200 mg of progesterone taken at night (may cause sleepiness).

Chapters

I'm not a fan of the synthetic progestins or synthetic estrogens, but I am a fan of the bioidentical ones, which in some cases are prescriptions. There's a prescription progesterone called Prometrium. There's many prescription estradiols. Anything besides prometrium is a fake progesterone. I would stay away from it. And there's no FDA approved testosterone for women commercially available product. Right now our testosterone is made in a FDA approved manufacturing facility and we use it as a pellet that's put under the skin along with a little bit of estrogen. And then we recommend progesterone orally. There's not a good pellet therapy for progesterone and progesterone would make sense. So right now we use a weight based Testosterone, typically a milligram per pound of testosterone. And then you typically about 6 milligrams or 1 20th that amount of estrogen. And this gives a physiologic response that's typically progesterone, one or 200 milligrams at night. Reason you take it at night is can create a little bit of sleepiness.