Testosterone levels alone don't predict who benefits from TRT. Mayo Clinic guidance says treatment response should be judged by symptom improvement, not just blood test numbers, similar to how blood pressure treatment works.
Mayo Clinic procedures published international consensus guidelines for treatment of low testosterone in men with symptoms of low testosterone. And one of their position statements was, there's no blood test that accurately predicts which men will benefit from testosterone replacement therapy. So if you have symptoms of low t, one of the only ways you can tell if testosterone replacement is going to work is to try a testosterone replacement and assess your symptoms. And a good example would be high blood pressure. We diagnose it with a blood pressure cuff, and we give a medication. And what do we measure? Do we measure the medication in the blood? No, we measure the blood pressure. Okay. So measuring the testosterone level to determine efficacy is probably a fool's game. There's not any level that predicts who will respond. And we don't really know what the ideal level of testosterone for men is.
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