Dr. Charles Mok reviews clinical studies on semaglutide and muscle loss. While some lean mass decreases with weight loss, the lean-to-fat ratio improves and studies show the loss isn't significant. The percentage of lean mass actually increased across the research.
Chapters
In study number three, this again, was done with adexa, and they saw the same thing. They found total fat mass reduced, visceral fat mass reduced, and increased proportion of lean body mass. Let's say somebody's 250 pounds and their ideal weight is 150 pounds. They've got a bigger skeleton to carry that weight around. They've got some muscle and bone density that's necessary to carry that larger frame around. When they lose weight, we want their percentage of absolute lean mass compared to fat to go up, not down. In each of the studies, it went up, not down. Now, in each case, they do lose a little bit of lean body mass because, again, they're not carrying as much weight, but it was not significant because their ratios got better. So don't be misled by people telling you you should keep this weight on because you might lose all muscle mass.