Effective Weight Loss: Tirzepatide vs. Semaglutide

Name: Effective Weight Loss: Tirzepatide vs. Semaglutide
Uploaded: 2024-07-03T12:00:27+00:00
Duration: 39 s
Channel: Dr. Charles Mok
Description: A short YouTube clip (single speaker) comparing clinical-trial weight-loss results for tirzepatide versus semaglutide. The speaker explains tirzepatide…

3 Jul 2024 · 1 min

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0:39

A short YouTube clip (single speaker) comparing clinical-trial weight-loss results for tirzepatide versus semaglutide. The speaker explains tirzepatide had three dose arms (5, 10, 15 mg), with ~15% body-weight loss at the 5 mg arm—similar to 2.4 mg semaglutide—and closer to ~20% weight loss at the 10 and 15 mg arms. The speaker cautions the trials were not directly comparable.

Questions this video answers

5 mg, 10 mg, and 15 mg (maximum doses described)

About 15% of body weight

Closer to 20% of body weight

2.4 mg semaglutide

No; the speaker states they "weren't in the same realm" and clarifies dose-dependence for tirzepatide.

Chapters

Just at a casual glance, if you read the New England Journal of Medicine studies that the companies did for weight loss, you would say, well, it looks like the triazepatide led to more weight loss than the semaglutide drug. Well, they weren't in the same realm. So in tirzepatide, the weight loss was dependent on the amount of milligrams the person got to. There was three different arms in the tirzepatide. One was a 5 milligram maximum dose, one was a 10, one was a 15 milligram maximum dose, and the 5 milligram maximum dose, they lost about 15% of their body weight, which was similar to 2.4 milligrams of semaglutide. So pretty similar. But in the 10 and 15 milligrams they got closer to 20% body weight loss, which we didn't see that much weight loss in semagutide.