From Cow Collagen to Cosmoderm

Name: From Cow Collagen to Cosmoderm
Uploaded: 2025-08-14T12:00:28+00:00
Duration: 30 s
Channel: Dr. Charles Mok
Description: Dr. Charles Mok explains the history and evolution of cosmetic dermal fillers, noting that early fillers included silicone, paraffin, and a patient’s own…

14 Aug 2025 · 1 min

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Dr. Charles Mok explains the history and evolution of cosmetic dermal fillers, noting that early fillers included silicone, paraffin, and a patient’s own fat. He describes bovine-derived collagen (from cow skin) which required pre-treatment skin testing for allergy, and the later replacement with human-based collagen produced by bacteria, exemplified by Zyplast.

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Filler ideally is used to restore lost volume. The first fillers were actually, they use things like silicone and paraffin and your own fat. Now, fat still is a suitable filler. Some problems with it, it's not predictable, but that's a common filler. Then out came Collagen products over 20 years ago. And the first collagen actually came from cow skin. They got collagen on the cow skin. Back then we had to skin test people, see if they're allergic to cows. Before they got their filler done. We put a little shot in their arm, a little sample of it, and then they replaced that with a human based collagen that was grown by germs, by bacteria, and that was called Zyplast.