Gut Brain-Axis Disruption in multiple sclerosis

Name: Gut Brain-Axis Disruption in multiple sclerosis
Uploaded: 2025-07-10T22:30:01+00:00
Duration: 25 s
Channel: Dr. Charles Mok
Description: A short lecture excerpt (Dr. Charles Mok) describing barrier dysfunction in multiple sclerosis: patients show impaired blood–brain barrier and impaired…

10 Jul 2025 · 0 min

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A short lecture excerpt (Dr. Charles Mok) describing barrier dysfunction in multiple sclerosis: patients show impaired blood–brain barrier and impaired gastrointestinal/bowel barrier ("leaky gut"). The speaker outlines a working hypothesis that certain gut pathogens may breach the gut barrier, enter the bloodstream, and potentially reach the brain, contributing to MS pathology.

The other thing that we see is there's an impaired blood brain barrier. There is a block between the blood and the brain. We have a blood brain barrier to keep stuff from getting into our brain. And that barrier is impaired in Ms. Patients. And they also have impaired gastrointestinal or bowel blood barrier. So they've got leaky gut. We're seeing is there certain. Appears to be certain pathogens in the gut that create a leaky gut, allow bacteria to penetrate into the bloodstream, maybe different bacteria that potentially get into the brain. So that's been a working theory for some years.