How Does Metformin Help Weight Loss?

Name: How Does Metformin Help Weight Loss?
Uploaded: 2024-07-11T12:00:39+00:00
Duration: 42 s
Channel: Dr. Charles Mok
Description: Dr. Charles Mok explains how metformin maintains weight loss after stopping semaglutide, a GLP-1 drug that works in the brain, pancreas, and gut. He…

11 Jul 2024 · 1 min

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Dr. Charles Mok explains how metformin maintains weight loss after stopping semaglutide, a GLP-1 drug that works in the brain, pancreas, and gut. He suggests cycling semaglutide for 12-13 weeks on, 6-8 weeks off, using metformin between cycles. For special events, occasional semaglutide doses can prevent weight regain.

Questions this video answers

Glucagon-like peptide 1 (GLP-1); semaglutide is a GLP-1 agonist acting in the brain, pancreas, and gut.

About 12–13 weeks on semaglutide, then stop for 6–8 weeks (cycle), with maintenance via metformin or 'bare marine'.

2024-07-11 (as stated in the source metadata).

Chapters

The target of semaglutide is glucagon, like peptide 1, GLP1. It's an agonist. And this agonist occurs in the brain and the pancreas and the gut. And if we stop the semaglutide, go on the metformin, typically, we're not seeing the weight return. If you got to your target weight, you can just stop there and use metformin. Maybe occasionally use semaglutide if you're getting in a situation where, you know, you might overeat, like going on a cruise or something like that, or maybe you have to get ready for a wedding and you want to do a little additional semaglutide. But for people who want to keep their weight off more definitively or lose more weight, we can cycle through this. We can go on the semaglutide for the 12 or 13 weeks, stop it for six to eight weeks, and maintain the weight with using some little help, like bare marine or metformin. They're almost chemically identical.