How Rapamycin Targets Aging Cells

Name: How Rapamycin Targets Aging Cells
Uploaded: 2024-04-03T12:00:53+00:00
Duration: 42 s
Channel: Dr. Charles Mok
Description: Dr. Charles Mok explains how rapamycin cream works on skin by stopping healthy cells from becoming senescent, or damaged. He contrasts two approaches…

3 Apr 2024 · 1 min

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Dr. Charles Mok explains how rapamycin cream works on skin by stopping healthy cells from becoming senescent, or damaged. He contrasts two approaches: killing existing senescent cells with senolytic drugs versus preventing them from forming in the first place, which could reverse skin aging.

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One of the things I'm really intrigued about is rapamycin's effect on the skin. We know the skin safety of the drug rapamycin, or sirolimus cream, because it's been used for certain conditions where tumors keep growing and actually suppresses the growth of tumors. And the way it works on the skin for aging is it seems to suppress conversion of young cells into old cells, and that's called senescence. So senescence is a hallmark of aging, where your cells, as they age, they become damaged and they turn into senescent cells, which are kind of like, toxic. And that is a hallmark of aging. Your skin. Your skin get wrinkly or saggy. And if we could either kill off senescent cells, which is called senolytic drugs, or you can stop conversion into senescent cells, this could potentially reverse aging.