Dr. Charles Mok explains how to measure brain age by comparing gray and white matter volume to cerebrospinal fluid. Brain tissue shrinks and fluid increases with age, and your percentile ranking shows Alzheimer's risk relative to peers. Interventions may reverse an older-appearing brain.
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But basically, we're looking at the amount of gray and white matter, which is the substance of your brain and the amount of liquid. Liquid is the cerebral spinal fluid that's surrounding your brain. And you look at the ratio of mass to liquid, more or less, we're looking at the weight of the mass or the mass of the gray and white matter and the amount of liquid. And as your brain ages, the gray and white matter shrinks and liquid expands, and we have less gray and white matter and more liquid. And you can look at it compared to your peers. If you're at the 50 percentile for your age, you're about average risk of beginning Alzheimer's. If you're at the lower 10 percentile, you got an issue that we need to address. If you're at the upper end of your age, you're really in good shape. Whatever you're doing is genetically, and your habits and your lifestyle are going in your favor. Now, if your brain is more aged than you are, there's definitely interventions that you could do to reverse your brain age.