Short YouTube monologue (speaker: Dr. Charles Mok) asking how to measure aging and summarizing three imperfect measurement approaches: blood-based biological age from routine chemistries, telomere length, and epigenetic age from DNA methylation clocks. The speaker emphasizes debate and imperfection in these measures but suggests they are informative when results differ substantially from chronological age.
Chapters
When we think about these drugs affect aging. How do you measure aging? And I talked about this in other podcasts and blogs before. There's not a perfect way to measure it. We have disagreement on what exactly is aging besides a chronological number. One would be your biological age on blood work. And these are looking at various chemistries that are very simple chemistries and say how do you compare to other people in your age group? A lot of debate about whether or not this is valid. I'd say it's definitely imperfect but. But it is valid. If your blood work looks like a person much older than you probably should take some attention if your blood work looks like somebody much younger than you probably do a lot of the right things tell them your age are these little ends on your DNA that say that you're potentially losing portion of your DNA faster or slower. And there's epigenetic age which is these little thing called methyl groups put on part of your DNA. They're keeping track of your aging.