Is Topical Rapamycin Good for the Skin?

Name: Is Topical Rapamycin Good for the Skin?
Uploaded: 2025-01-01T13:01:08+00:00
Duration: 40 s
Channel: Dr. Charles Mok
Description: Dr. Charles Mok reviews a study on topical rapamycin applied to one hand while the other served as control. The treated hand showed clinically younger…

1 Jan 2025 · 1 min

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Dr. Charles Mok reviews a study on topical rapamycin applied to one hand while the other served as control. The treated hand showed clinically younger skin, reduced senescent cells, increased elasticity, less sagging, and smaller pores.

Questions this video answers

0.001%

Applied daily or every other day

Within-subject: one hand treated, the other hand used as control

Fewer senescent cells (skin appeared younger on biopsy)

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So a study done at Drexler looked at using rapamycin on the skin. They did study on the hands, where they use one hand as the study hand, the other hand as the control hand. And they put a low strength of rapamycin, 0.001% on the treated hand every day or every other day one time. Just a small amount they found was that the skin not only looked better, but when doing biopsies, they found that the skin was actually younger, had less senescent cell, the skin was more elastic, less saggy, had better color, less we call solar damage, the less pore size we see clinically, and this is using the drug sirolimus, also known as rapamycin, topically every day or every other day.