Maximizing Semaglutide Efficacy and Tolerance 💪

We have this ability to look at tolerance and extinction of tolerance. We also can see that most of the weight loss occurred in the first three months. That's where the most rapid weight loss occurred. More than half of the weight loss occurred at that point. And we have a drug that's expensive and shortage, so how can we use less of it? And we know that the maintenance dose, which doesn't cause weight loss, is 10 times higher than the starting dose. So what can we do? We also know that foramen increases GLP1 levels and can be used synergistically with it. We typically don't start metformin and semagluta at the same time because they both have GI upset as a side effect. And if you were to get that, you wouldn't know which drug is causing it. But they can be taken together.