Platelet-Rich Plasma and Platelet-Rich Fibrin

Name: Platelet-Rich Plasma and Platelet-Rich Fibrin
Uploaded: 2025-02-13T13:00:06+00:00
Duration: 49 s
Channel: Dr. Charles Mok
Description: Short instructional segment comparing platelet-rich plasma (PRP) and platelet-rich fibrin (PRF). The speaker explains that PRP is typically prepared with…

13 Feb 2025 · 1 min

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Short instructional segment comparing platelet-rich plasma (PRP) and platelet-rich fibrin (PRF). The speaker explains that PRP is typically prepared with anticoagulant additives (e.g., sodium citrate) which prevent platelet activation and growth-factor release; additives can be reversed before injection to induce clotting and convert PRP into PRF. The speaker also describes newer additive-free blood-draw and centrifugation methods that produce liquid PRF with limited stability (~20 minutes at room temperature, ~40 minutes refrigerated) and avoid additives that impair platelet growth-factor release.

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Platelet rich plasma typically means that the platelets have been more or less paralyzed by an additive or chemical in the tube, most notably something like sodium citrate. And that keeps the platelets from giving off the growth factors and clotting so it can be handled easier. But then right before we inject it, we may add another additive to reverse the anticoagulant. Therefore the platelets can go ahead and give off their growth factors and then that makes platelet rich plasma into what we call platelet rich fiber and actually clot up. That term is not used so much platelet rich fiber until recent years because now we have way to actually draw the blood without additive, using special types of tubes and a special type of centrifuge to get liquid platelet rich fibrin that's stable at room temperature for about 20 minutes and stable in a refrigerator for about 40 minutes. And that's what we're using now. And we're not adding the additives that might impair the ability for the platelets to give off their growth factors.