Dr. Charles Mok explains how platelets work in blood clotting and wound healing, delivering growth factors that recruit cells for tissue repair. Platelet-based therapies like platelet-rich plasma may offer an alternative to knee replacement surgery, though platelets have limited control over scarring.
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Platelets are cell like structures in your blood that along with red blood cells and white blood cells, make up the structure of your blood. And the rest of it is a juice. And in that juice there's different things. Like there's things that are being carried to your kidneys and liver to get rid of, and there's things to move to different tissues. There's growth factors, antibodies, there's all kinds of things in your plasma. And we take the blood out, we can separate out the platelets and the plasma from the red blood cells, even potentially from the white blood cells. And when we separate those out, we've got these platelets that are designed to fit things. So when you cut yourself, your platelets rush in and they make you clot up, so you stop bleeding. That's good. And then they make your skin grow, they bring stem cells in and they bring fibroblasts in and the wound closes up and it heals and you get a little scar there and it's done. As a result, you might have a bad scar or a good scar based on the type of trauma in the first place. Platelets have very little control over that.