Premarin And Provera For Menopause

After sheep ovaries, we used pregnant mare urine Premarin, which was a group of conjugated estrogens that somewhat mimicked the effect of estrogens that woman would make naturally. She would take it as a pill, and that was very effective for reducing symptoms of menopause. We'd use that along with progesterone, because if you use Premarin alone, the uterus would overgrow. Potentially, 13% of women would get uterine cancer unless the uterus is mitigated with progesterone. Then we added in Probera, which is a synthetic form of progesterone. And that led to some big studies that were really missing, understood by the public, called the Women's Health Initiative Trial. And back in 2002 and 2004, we kind of abandoned the routine use of hormone replacement therapy because of fear of heart disease and breast cancer.