Drexel researchers applied low-strength rapamycin cream to one hand for several weeks. The treated hand showed fewer wrinkles, smaller pores, and thicker skin with more collagen. Biopsies found fewer senescent cells and better-organized tissue structure.
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So a study at Drexel University, Philadelphia, did a split body study. One hand was treated, one hand wasn't treated. Where they used a very, very weak strength of rapamycin cream, put on the hands every one to two days for several weeks. And they looked at signs of aging on the skin on the treated hand versus the untreated hand. What they found was that the skin looked younger in the treated side, had less wrinkles, looked to have less pore size and less damage to the, to the elastin. And when they biopsied the skin, they found more collagen, a more organized basement membrane. They saw better elastosis or better retractability. They saw thicker dermis, which is good, and they saw less senescent cells.