A small trial applied low-dose rapamycin cream to one hand and placebo to the other. After several months, the treated hand showed thicker skin, increased type VII collagen, and fewer senescent cells. The dose was about 100 times weaker than tumor-treatment doses.
Chapters
The study was done, healthy volunteers that had they did that in their hands. They have a control hand when they use a fake cream and the sirolimus cream or rapamycin cream and use a strength 100 times weaker than the strength used to treat tumors. So it's very low dose and it's known to be safe at these higher doses. What they found was that the skin after several months was younger in appearance, but not only in appearance. They had more what's called type 7 collagen, which is a collagen that bonds the epidermis, the outer layer skin to the dermis, the inner layer skin in a layer called the basement membrane. That's a layer of your skin that houses all your stem cells. And what they found was that there's less senescent cells in the treated hand versus the untreated hand. They kept kept getting older. The skin looked thicker because there was more collagen. The skin looked younger, it had better texture.