Dr. Charles Mok explains why dermal fillers break down: injection trauma and reactive oxygen species damage filler in the first days, then repeated motion like talking reactivates that breakdown. Low-motion areas like temples last years, but fillers aren't truly permanent.
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When the injection is done, there's a little bit of trauma from it, and your body makes something called reactive oxygen species that break down a certain percentage of the filler. So we lose a little bit over the first few days, and then naturally, through time and motion, let's say you do filler on your lips, there's a lot of movement from talking, and reactive oxygen species are awakened again, and it slowly breaks down and it's redone. Other areas, say the temples under the eyes and nose, where there's very little motion, it could last for years or a decade because there's very little motion. We can't ever say it's permanent because we don't really know that, but it potentially is permanent. In certain areas with low motion, it.