Semaglutide Doesn’t Reduce Lean Muscle Mass

Study number one, 2020 weekly semaglutide dose for 26 week study. They found that people lost visceral fat fat mass, and they had no significant loss of lean muscle mass. Now, what happens is that when they say no significant loss of lean muscle mass, it depends on how it's worded. They're looking at relative lean muscle mass compared to fat free mass. So when somebody has a high weight and their weight goes down, there's typically some degree of lean muscle mass that goes down with it. But what's the ratio of lean muscle mass to fat mass? It actually gets better, and that's actually favorable for a human being. So in other words, if somebody's very heavy, they have to have a heavy skeleton to carry that weight. So their DEXA scores improve with DEXA reports in percentage of fat free mass.