Semaglutide For Weight Loss: A Study

Name: Semaglutide For Weight Loss: A Study
Uploaded: 2024-06-12T16:00:20+00:00
Duration: 43 s
Channel: Dr. Charles Mok
Description: Dr. Charles Mok breaks down the SELECT trial, a four-year study of semaglutide for weight loss. Participants lost about half their total weight in the…

12 Jun 2024 · 1 min

Watch on YouTube

0:43

Dr. Charles Mok breaks down the SELECT trial, a four-year study of semaglutide for weight loss. Participants lost about half their total weight in the first 12 weeks, with most loss happening in the first 40 to 60 weeks, then held steady for years. Average reduction: 10% of body weight.

Questions this video answers

Four years

12 weeks

Over the next ~50 weeks (so most loss occurred within ~40–60 weeks total)

About 10% of body weight

People who were overweight or obese placed on semaglutide

Chapters

So the largest trial to date is called the select trial SCLACT trial. This was a four year study with people that were overweight or obese who were put on semaglutide to watch their weight loss. They lost weight rapidly over a period of about 40 weeks or so, maybe 60 weeks, and then they kept it off for four years. But interestingly, most of the weight loss, in fact the majority of the weight loss occurred very, very early in the study at the much lower doses. In fact, half of the weight loss occurred at 12 weeks. The next half of the weight occurred over the next 50 weeks, almost a year, and then no more weight was lost and they held it for about four years. In fact, the average weight loss in the select trial was 10% of body weight.