Sirolimus Lessens Cellular Senescence

Name: Sirolimus Lessens Cellular Senescence
Uploaded: 2024-04-19T23:45:02+00:00
Duration: 39 s
Channel: Dr. Charles Mok
Description: A short clinical commentary (Dr. Charles Mok) describing topical sirolimus/rapamycin cream use in practice since 2021. The speaker reports evidence of…

19 Apr 2024 · 1 min

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A short clinical commentary (Dr. Charles Mok) describing topical sirolimus/rapamycin cream use in practice since 2021. The speaker reports evidence of reduced cellular senescence and clinical improvements—smaller pore size, improved fine lines, and better skin color/texture—moving toward a more youthful appearance. Safety is noted, with the speaker remarking that much higher systemic doses (about 20× higher) are used in children for certain tumor conditions.

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In the skin of this treated hand with sirolimus cream, which is rapamycin cream. We call it sirolimus. They're the same drug. They had evidence that there's less cellular senescence. So that's very positive. So we're seeing, clinically, we've been using it since 2021 in the practice, four years or three years, and we're seeing pore size shrink, we're seeing fine lines improve, we're seeing color and texture improve, and we're seeing more trend towards youthful age. The satisfaction we have is met with safet. So the safety data, this drug is used in children at a much higher, about 20 times higher dose for these tumor conditions.