Sirolimus Lessens Cellular Senescence

Name: Sirolimus Lessens Cellular Senescence
Uploaded: 2025-02-27T13:00:09+00:00
Duration: 37 s
Channel: Dr. Charles Mok
Description: Short clinical commentary by Dr. Charles Mok on topical sirolimus (rapamycin) cream. He states evidence of reduced cellular senescence and reports…

27 Feb 2025 · 1 min

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Short clinical commentary by Dr. Charles Mok on topical sirolimus (rapamycin) cream. He states evidence of reduced cellular senescence and reports clinical observations since 2021 including reduced pore size, improved fine lines, better color and texture, and an overall trend toward a more youthful appearance; he also notes safety context that the drug is used in children at roughly 20× higher doses for certain tumor conditions.

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In the skin of this treated hand with sirolimus cream, which is rapamycin cream. We call it sirolimus. They're the same drug. They had evidence that there's less cellular senescence. So that's very positive clinically. We've been using it since 2021. And we're seeing pore size shrink, we're seeing fine lines improve, we're seeing color and texture improve, and we're seeing more trend towards youthful age. The. The satisfaction we have is met with safety. So the safety data, this drug is used in children at a much higher, about 20 times higher dose for these tumor conditions.