Sustaining Weight Loss Beyond Semaglutide

Name: Sustaining Weight Loss Beyond Semaglutide
Uploaded: 2025-09-04T12:00:40+00:00
Duration: 46 s
Channel: Dr. Charles Mok
Description: Excerpt from a YouTube talk describing an internal 13-week semaglutide run-in among employees that produced ~14% average body-weight loss (predominantly…

4 Sept 2025 · 1 min

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0:46

Excerpt from a YouTube talk describing an internal 13-week semaglutide run-in among employees that produced ~14% average body-weight loss (predominantly women). Participants were taken off semaglutide, given metformin (reported to raise GLP‑1), and allowed intermittent semaglutide self-dosing from an office supply as needed; at one year participants reportedly maintained the weight loss.

Questions this video answers

13 weeks

About 14% of body weight

Metformin

Everyone kept their weight off at one year

Mostly women (very few men)

Chapters

We did an internal experiment with employees. We put people on a 13 week run in of Semaglutide. And why 13 weeks? That's how the medicine was applied for us. And we saw people lost about 14% of their body weight in that 13 weeks. And the range of weight loss was varied based on how much they weighed to begin with. It was mostly women. Very few were men in our company, mostly as women. And then we took them off of it and then we gave them metformin which is a diabetes medicine that helps with weight and it also raises GLP1 levels. Interesting. Which is a target of the semaglutide. And then they were allowed to use semaglutide again as needed. Where we had a bottle of semaglutide in the office and they felt like they were kind of falling off the wagon. They'd give themselves a shot or go through another four weeks and stop it again. That worked very successfully. At one year everybody kept their weight off.