Targeting Genes to Extend Lifespan 💯

Name: Targeting Genes to Extend Lifespan 💯
Uploaded: 2024-02-26T14:00:30+00:00
Duration: 34 s
Channel: Dr. Charles Mok
Description: Lecture excerpt (Dr. Charles Mok) describing genes targeted to extend lifespan, with emphasis on mTOR (mechanistic/mammalian target of rapamycin)…

26 Feb 2024 · 1 min

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Lecture excerpt (Dr. Charles Mok) describing genes targeted to extend lifespan, with emphasis on mTOR (mechanistic/mammalian target of rapamycin). Speaker states that rapamycin, which inhibits mTOR, lengthens lifespan across studied animals regardless of treatment start age (example: both early- and late-starting mice lived ~30% longer). Human trials are described as ongoing.

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But there's three of the genes that we know we can or we believe are targets for drug therapy to extend aging. So mtor, mechanistic or mammalian target of rapamycin. If you turn that off, our longevity increases. In all clinical studies, which has not been fully done in humans, it's ongoing right now. But in every animal plant studied, when they're given rapamycin, they live longer. What's more, it didn't matter when they started the rapamycin if they started it. Let's say you take a two year old, a month that lives two years, and you started the mouse at six months or 18 months. Both groups lived about 30% longer. So. So rapamycin affects mtor.