The Sinclair Method uses naltrexone, an opioid-receptor blocker taken before drinking, to gradually reduce alcohol cravings and pleasure. Over one to eight months, patients can cut back substantially or return to occasional social drinking.
The reason called Sinclair method. There's an English doctor Sinclair, who thought that perhaps we should be approaching alcoholism. A different fashion with the Sinclair method is using naltrexone, which is a drug designed to block the euphoria receptors, might be used for narcotics. The person takes this at least an hour before they drink. They go out and continue drinking. And over time, usually a month to six or eight months, that crave for alcohol starts drying up a little bit, and the euphoria from alcohol doesn't happen. They lose the psychological interest in that physical interest in drinking alcohol, and then that interest extinguishes over time. Some people might do this and just use it as a way to substantially cut down their drinking, but be able to continue to drink socially once in a while. But they would have no interest in, say, drinking at home anymore. That's the idea.
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