Understanding Semaglutide Dosing

Name: Understanding Semaglutide Dosing
Uploaded: 2024-06-11T12:01:00+00:00
Duration: 34 s
Channel: Dr. Charles Mok
Description: Dr. Charles Mok presents a short YouTube talk explaining semaglutide (brands Ozempic for diabetes, Wegovy for obesity) and focusing on dosing behavior…

11 Jun 2024 · 1 min

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0:34

Dr. Charles Mok presents a short YouTube talk explaining semaglutide (brands Ozempic for diabetes, Wegovy for obesity) and focusing on dosing behavior. He introduces the pharmacologic ideas of drug tolerance and "extinction intolerance," notes that maintenance doses can be about ten times higher than starting doses, and states that little additional weight loss typically occurs once maintenance dose is reached.

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So I'm going to talk about semaglutide and pulsing the dose of semaglutide. So let's go over this drug. This is the drug also known as Ozempic for diabetes and WeGovy for the use of obesity or overweight with comorbidities. And the dosing schedule is very interesting. So we, we have something called drug tolerance and extinction intolerance. Drug tolerance is where you take something over and over again and you need more and more and then eventually stops working. This is classic with semaglutide. In fact, the maintenance dose is 10 times higher than than the early starting dose. Once you get to the maintenance dose, you generally don't lose any more weight.