What Are Senescent Cells?

Name: What Are Senescent Cells?
Uploaded: 2025-02-26T17:00:43+00:00
Duration: 42 s
Channel: Dr. Charles Mok
Description: Short educational video by Dr. Charles Mok explaining cellular senescence: cells accumulate replication errors, become senescent (stop growing/dividing)…

26 Feb 2025 · 1 min

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0:42

Short educational video by Dr. Charles Mok explaining cellular senescence: cells accumulate replication errors, become senescent (stop growing/dividing), and signal nearby cells to stop dividing, contributing to organ dysfunction. The speaker gives arthritis (senescent chondrocytes) as a clinical example and mentions treatments such as stem cell injections and platelet-rich plasma.

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Our body ages and we go through something called senescence in our cells. So your cells always replace themselves over and over again. As these cells turn over, errors are made in the genetic copying. And when that happens, the cell becomes senescent and it stops growing, it stops dividing, and it stops replicating. It also signals cells in an immediate area to stop replicating and stop, stop dividing. And this leads to organ dysfunction and then eventually organ failure. A classic example would be arthritis. If you look at cells, these chondrocytes, the cartilage cells, they're, they're senescent, they're just not really doing anything. We treat them by injecting stem cells or platelet rich plasma to try and do something to wake these up. So that's senescence.