Aging Clocks: How to Reverse Aging with Dr. Vincent Giampapa | 1189 | Dave Asprey

You can add cells back in. And I've been working on adding mine back in. And the fact that you can just come down, get them collected and stored, and we're right at the edge of being able to edit those cells or upgrade them so that you can make them younger or even give them some special powers. You're listening to the Human Upgrade with Dave Asprey. You're listening to the Human Upgrade with. It's Dave Asprey. This is an amazing episode about to happen. I'm down here in Costa Rica at a place called RMI with one of the luminaries in the field of aging, someone who's practiced for 40 years and someone who was a founder of the American Academy of Anti Aging Medicine a very long time ago. And people say, dave, how did you get to be such a good biohacker? It's because in my mid-20s, I was learning longevity from guys like Dr. Vince Jam Papa. And when you work with someone who's just spent decades on this, you realize what's possible. So I had the great honor of learning from my elders when I was young. And I've had so many good conversations with Vince that I want to share some new information with you. I'm looking kind of beat up right now. I've got. I just had, I don't know, my 15th IV or something this week. I've had my central aging clock reset in a brand new, groundbreaking kind of longevity technology. And I'm going to walk you through what I just did. And for years, people have said, because I don't read the books, longevity is a game for wealthy people. And I've been saying, no, the price keeps coming down. It keeps coming down. And I've done a few episodes over the past few years where I spent about a hundred thousand dollars on just getting stem cells in certain parts of my body. And what I just did this this week is unbelievable because it's way less than half the price and so much more potency and so much more longevity. And this is groundbreaking. So my expectation is that every couple years, the potency and the price comes down. It's just like computer chips. If you're a nerd, you might have heard of Moore's Law that says every 18 months, the speed or the density of processors, not the speed, but the density doubles. We're doing this with longevity right now, and Vince is an absolute leader in the field. Dr. Vince Jambaba, welcome to the Human Upgrade.

Dave, it's my pleasure being here with you. And as you said, we've had some multiple other conversations about where this whole new specialty of medicine is going. And it's just a pleasure today to share with you some of my thoughts. And I'm really glad to have you here as our guest and experience one of these new amazing technologies.

It's hard to know where to start with you, but I want people to know a little bit about your background. There are some names, people who've just recently written books. In fact, one guy wrote a book that says you can't extend human life, and he charges a quarter million dollars to tell people that they're just going to d die at their normal age. And I scratch my head at that when I look at. You've written five books, right?

Yes. Yes.

And what was the most recent one?

Well, the most recent one is actually still in its final stages of being released. And that's all about what we're going to talk about today.

Oh, no kidding.

All right, so that'll be out, I would say, within six months. But the most recent one was an upgrade of the textbook for aging physicians or people who want to practice anti aging medicine. So that's the basic principles and practice of anti aging medicine.

So you're teaching doctors how to do what you've been working on for 40 years.

I want the information that I know to be available to as many other physicians who really want to do something that changes the model of medicine from a symptom treatment model to a preventive model. And it's really about how do we keep all of us healthier, more functioning longer as we grow older?

Well, there are a lot of physicians, especially functional docs, longevity docs, and healthcare providers who listen to the show. And tons of people like me who just want to feel better, live longer, just show up all the way. And this probably isn't where I would have started, but cognitive enhancement is so, in my mind, integrated with longevity. I've always been putting those as two pillars of biohacking. How do I live longer? How do I make my brain work better? And of course, my body. What do you take every morning to make your brain work better?

Well, I have a, A personal protocol, actually B, based on a new version of MRIs that actually can look at how your brain is aging and that those new MRIs are actually put into a new software that literally can look at every segment of your brain.

Wow.

And actually tell you what your neurotransmitter levels are. What your SOD levels, your glutathione peroxidase levels, where inflammation is more prominent in certain regions of the brain. And so based on this whole new diagnostic way of looking at your brain in three dimensions and its function, there's for instance, there's supplements we use from Prodrome sciences. One is a special form of curcumin which decreases the brain inflammation. Another one is just designed to help enhance your glial cells. And another one is to help enhance different other portions of the brain.

These are called plasmaallogens. Right.

Plasmologens Plasmalogy.

I always say, yes, I take some of those as well. You have an enhancement stack that's more nootropic focused.

So from the nootropic point of view, that's always been a tremendous area of interest for me. So I use a stack with individual or armidophenil at a lower dose, usually around 75 milligrams. I use centrofenoxine and I use piracetam or no, tropical nocentrophenoxine helps with memory recall, but piracetam helps with left to right brain hemisphere transfer. So that actually enhances your creativity. Now Nuvigil helps with in general multiple types of memory, short long term memory, but also reaction time balance and helps with both. Again, together with this cognitive enhancement stack, you see multiple aspects of memory enhancement along with creativity. So to me, the secret here is to be at the top of your game so you can absorb all the information but still be creative and see how those new pieces of information fit together.

How old are you?

My age is kind of actually like my st. My cell number, it's unlisted. But for you I will, I will admit I. I'm going to be 74.

So you are the healthiest looking, most dialed in person over 70 I've ever met.

Well, thank you. That's a big compliment coming from you.

And I take a similar stack of nootropics in the morning. I use modafinil, which is the grandfather of new vigil, which you talked about.

Yep.

And we were just talking. Maybe I'll try and swap. I used to use centroquinoxanine, but I tried it a long time ago when I was younger and it was too much for me. But I feel like I should be back on it. It also is a potent brain anti aging thing. I use a cousin of Pirasadam called aniracetam.

Yep.

And I like that one because it's also got memory IO enhancement. And people say, Dave, how do you remember all this stuff? I've been doping for 20 years on memory enhancers. It kind of works. And it also protects the brain. So we're both making our brains last longer that way. But those are, you know, tactical things compared to the aging things we can do.

But I want to mention one thing that you taught me. This was back in Dubai. 7, 7, 8 dihydroxyflavone. I love this one. So that enhances BDNF. So that is something I forgot to mention that since I met you a couple years ago there that's been part of the stack. Hi.

This is a beautiful supplement, dihydroxyflavone. It's something that does similar to what psychedelics do in terms of bdnf. But it doesn't make you trip sadly. Now that's just to get. How is it that I'm sitting here with a guy who's for 40 years been practicing, who just is at the cutting edge of everything. We did some procedures this week and I'm going to ground listeners in sure the type of stuff I've done before. So I used to in the US it was about a $100,000 procedure. Actually helped to co develop it called a. A six hand stem cell whole body makeover or something like that. But it was brutal. Like a week of feeling like you got hit by a truck. I will never forget the feeling of having a hammer going into my iliac crest of my hip and that sound as they're getting into the bone marrow. Then that twice. One time I had a seizure. It sucked.

So not a happy experience when I.

Came down here to your clinic in Costa Rica and guys, Costa Rica is a three hour flight from the US and it's so easy to get to. But instead of doing that, you had me take some pharmaceuticals for a few weeks before I came down. And then you just took the same stem cells out of my blood without having to penetrate my skeletal system.

Exactly. Okay, so what you had done is what we call our procedure is called. It's a treatment. Your really first anti aging treatment. But it's. We also call it your bioinsurance program. So why do we call it bioassurance is we're able to collect the three most important types of stem cells adults have that enhance that are responsible for maintaining your immune function, the repair and maintenance of your blood vessels and your regenerative component so that your organs, skin, muscle, brains even and bone tissue all can repair the damage that's occurring during the general aging process that occurs day to day. So this technique is unique and it uses an FDA approved compound for over 40 years called NeuPOGEN or GCSF. Now, that is a unique compound because it's used for the last 40 plus years for people who have to have their bone marrow ablated because they have cancer. Then they get their stem cells collected prior to that so they can then get them infused back after their cancer treatment and grow a new immune system. Now, 15 years ago, I started to do that as an elective wellness procedure. And so but in the US you can't do that as a preventive thing. It's illegal in the US to collect and store, but you can't get yourselves back for preventive wellness reasons. Now that is kind of a little bit of an oxymoron, right?

It's almost like someone thinks that they have any say over what I do with my own cells. They're wrong.

Listen, I happen to 100% agree with you, which is one of the reasons we're here in Costa Rica.

If you want to stay healthy as you age, you need to keep your muscles and ready to move. You might think the answer is to hit the gym harder, but there's a hack for this. So you don't even have to add a single rep to be stronger. It's called Mito Pure by Timeline. As you age, your muscles naturally start to shrink and you feel tired and worn out. Studies say that weakened mitochondria make you feel that way. Mito Pure by Timeline gives your mitochondria a big jump start, which means better muscle strength and endurance even if you don't hit the gym more. I use Mitopure and it's a real game changer. Give Mitopure a try for two months and you'll feel the difference. At least that's what the studies say. And hey, if you visit timeline.comdave you'll even get a sweet discount. There's so many reasons that that I'm blown away by what I've experienced this week. Because having fat taken out for getting stem cells is also really painful. And usually I get muscle cramps. One of my companies is called Wasabi Method, right? We have this new form of pressure wave that I have to do that where I've had the fat taken out to get my muscles to relax again. So violating your bones and your fat to get stem cells is annoying and painful and expensive, right? So your procedure for that is better. And if you're listening to this and you're under 45, you can bank yourselves when they still have some powers that you lose after about 45 and then you have those cells for the rest of your life. So I've had mine banked, unfortunately, after I was 45, I have some of my fat cells banked from before I was 45, I think. And what's happening now though, is you come down here, you get that done, and you can do everything else you can think of. And we're going to go through all the stuff I did, but we're right on the edge of being able to edit our own stem cells. Tell me about that.

Yes. So my original focus was to be able to collect and store stem cells when we are optimally healthy, so have this reservoir of a regenerative potential in order to use as we grew older. And I've had my children's stem cells collected in their early 20s. And believe it or not, my son's now 40. He's starting to get those 20 year old STEM cells back so that he doesn't collect the damage that we have as we have grown older. But the whole, the whole secret here is that those stem cells that we've collected, which are the three major types of stem cells. Now when you collect fat, by the way, you only get mesenchymal stem cells when we collect from the blood or the bone marrow, which we get hematopoietic endothelial progenitors for our blood vessels, and then we get the mesenchymal stem cells also. So why would we want to have to just traumatize our bodies to get just one type? And we get all three types.

I am planning to never have my fat or bone marrow taken again. I don't need to do that anymore because of the work that you've done here.

But you don't have any fat left anyway.

It's actually a problem.

But a good problem.

Yeah. When we measured my body fat at the beginning of the procedures, I was at 4.8%, which was a low. And I probably need to put some fat on any, any techniques for that.

You know what? I think you, I think where you are now is where you ought to stay.

So you mentioned there's three kinds of stem cells.

Yes.

Give me one sentence about each one and why we care.

Now, hematopoietic stem cells form the basis of our immune system, which is the most important component of that is your NK cells. Okay. Which are really what protect you against cancer, bacteria, and even senescent cells, which we'll talk about in a bit. Then there's the endothelial progenitors, which are what we need to maintain or grow new blood vessels as they perhaps get damaged or occluded. And lastly, there's the mesenchymal stem cells that are the regenerative cells that are can form muscle, bone, cartilage, and even brain tissue. So keep in mind you're born with a fixed number of stem cells and everybody's a little different. But once you hit 40, you lose both the number and function of those stem cells. So there's no wonder why we start to get more infections, or we have poor blood flow to our brain or our organs, or we can't regenerate those organs, or we lose cognition. So it's directly related to the aging process. So this is a kind of a new way of looking at things. You know, it's been said that we people who look at everything that everyone else has seen and don't see something different are really not looking hard enough.

Wow. It's a new day for that because you can add cells back in. And I've been working on adding mine back in. It's just been a traumatizing and very expensive process. And the fact that you can just come down, get them collected and stored, and we're right at the edge of being able to edit those cells or upgrade them so that you can make them younger or even give them some special powers. This has been on my list of of things for 20 years. What's coming?

Well, a lot of this might sound a little bit like sci fi stuff or the Born Identity stuff, because the actual last Born Identity movie is. Was talking about exactly what we're now at the brink of being able to do. So let's talk about that. So right now, I think the focus in, in the research component of stem cells has to do with reprogramming. That means taking the stem cells we've collected, which have a certain gene activity profile, and resetting them back to a 30 year old or a 20 year old. Now that sounds like. Well, that's so far out. No, it's not. That's been done with the Yamanaka factors. That's been done with a whole host of things. And recently we've actually been able to do that with certain medications that have been FDA approved for 40 years. So we're at the verge of now actually starting clinical trials to document the safety and efficacy of that.

In fact, I'm joining that clinical trial. Shocking.

Yes, you are. But let me just tell the other thing. In 2016, we looked at this model called heterochronic parabiosis, where you saw the mice together, the old one and the young one.

Yeah, I wrote about that in super human. My longevity book.

Right, Exactly. So what goes from the young mouse to the old mouse that makes that old mouse act and look and and biologically be younger are specific compounds which we now know what they are.

Okay.

So in 2016, I decided to try that not with sewing two humans together, but putting young and old stem cells together.

Oh, okay.

So that was a technique we did at Rutgers University. And for the first time, we were literally able to reverse not only the gene activity, but the proteins and how those cells reacted virtually identical to the young cells.

Wow.

And for the first time, we reprogrammed 70 and 80 year old human stem cells back to 20, 30 year old stem cells.

Does that mean I can release the college student change under my bed for blood?

Maybe. Yeah. Get rid of that stuff. There's easier ways to do it. The technology. Listen, I want to make this comment, and this probably should be something we repeat every three months. What we know about aging and related technologies doubles. So what does that mean? Three years from now for you and I, it'll be 6,000 times more information.

And it comes down to just knowing what to do. And at this point, the evidence is in. Stem cells are important, but in the US access is so limited and people are getting cells from eight different random women. It's not their cells. When I come down here, I like it because I can use my own cells or the only cells from outside my body I'm willing to use is what's called cultured umbilical cells.

Correct.

And that means that they take one line of cells that's very carefully tested and then they grow it, versus just taking random people's cells because there are risks from getting lots of cells from lots of people. In the US they do it that way because of weird legal stuff, but it's, I think, not very safe. And I'm all over doing this down here in Costa Rica because, well, you can do much more. So we've got stem cells.

Yes.

We also have what I call stem cell poop exosomes.

Yes.

So stem cells secrete anti aging, anti inflammation factors, and you can take those directly. So what we did is something I want to share with you because I know a lot of people reach out and saying, dave, I want to do what you're doing and you can go to daveasprey.com clock and you can sign up to get information about this stuff. And what we did is really groundbreaking because your team used focused ultrasound to open up specific parts of my blood brain barrier. And then I had stem cell and exosome infusions to reset my hypothalamus. Why would I want to do that?

Yeah, so, you know, we're at a pivotal point today in. In longevity and regenerative medicine, where we can start to do things that I believe and have. And I'm standing on the shoulders of people who have done this, done the research in animals. And one of those is Dr. Sheldon Jordan, really, to get the credit luminary in the field? Absolutely.

I'll have him on the show soon.

We've worked together on. On this process, and under his guidance, what we've been able to do is use focus ultrasound and target specific areas of the brain. The hypothalamus seems to be the central aging clock in the body. Now, this might sound a little far out, but there's real evidence in both. In fact, a paper published in the last lesson, the last year in nature magazine that documents the hypothalamus. On the floor of that hypothalamus are neural stem cells. Okay. And there's multiple nuclei. Your. Your. The nuclei that regulates your sleep, wake cycle, your sleep, how you sleep, your hormonal release patterns, a whole host of things that directly impact the peripheral aging clocks, which are our stem cells and body cells. So that's why we're targeting the hypothalamus, because it's our belief now that if we can help restore the sensitivity to those nuclei, that they can sense the changes in the body more efficiently. Like when you're your 20s and 30s, they help keep your peripheral aging clocks working more efficiently.

The body's amazingly like a computer system in some ways and completely unlike in others. But people who don't come from Nerdville like I do, you wouldn't know this, but inside every computing device you have is a tiny little clock that makes sure everything in the system knows what time it is. Because all those components, if they're doing the right thing and they're off by just a microsecond, everything stops working. Our body has that central clock, and it also has individual clocks in each cell and in each organ system.

Exactly.

But they have to talk to the central clock. Sort of like when you turn your phone on and it checks in and it knows what time it is because it talked to the cell phone network. It's like a central clock, and that's tied back to an atomic clock. That's how all of our human stuff keeps working. Train schedules and whatever body's the same way. So we just told my central clock, it's way younger so it's going to tell all my peripheral stuff that they're way younger.

Exactly. It's going to help sync those two clocks. But how does that focus ultrasound do that? And what do we add to that procedure to make that as efficient as possible? So, you know, focus ultrasound has always been known to help with certain components of cognition and other things, because where it's focused in specific part of the brain, it causes vasodilatation or opens up the local blood supply. So the hypothalamus is a pretty easy target to hit with an external focus ultrasound. Beep. So what happens is not only does the blood supply to that area stay more active or larger for a number of hours after a treatment, but it does two other things. The first thing it does is what we call stickiness. So that allows certain proteins that we're going to infuse right after that, that focus ultrasound sessions over to stick right to the blood vessels of that area. The second, the other thing it does is it causes what we call endocytosis or allows these pieces of genetic material, DNA, micro RNA cytokines, growth factors, to go through blood vessels and directly into the neural tissue that we aim to beam at. It's kind of like neurosurgery with no surgery.

Wow. And for reference, this procedure, which is a really potent longevity procedure, is about $25,000 by itself. But what I did is I came down and I said, well, make me one with everything. So we created a stack, and it's a stack. If you go to daveaspree.com clock, I'll give you the full details and all there. But what we also did is my face. I'm looking a little bit ragged today. If you can see that, it's because I did heavy duty stem cells microneedling and CO2 laser on my face. And then we did a bunch of ortho work and injected stem cells and other things into my reproductive system. So this is the whole body approach, everything that needs it, plus the brain. But we did something else that I think is groundbreaking. Even though you can't see it, quantum energy pulses through everything. It's all around you and it's in you. And there's science that backs up the fact that your body is a quantum system. But toxins and stress can throw your energy off balance. And that's where a company called Quantum Upgrade steps in. Quantum Upgrade offers groundbreaking products to help you get your balance back. Quantum Upgrade tests each product on humans, and the results show that the technology can boost blood flow and Even reverse blood clots in minutes. The latest and greatest study shows that Quantum upgrade increases ATP production by up to 29%. And the newest ability is that you can now use Quantum Upgrade to increase your level of consciousness. Based on the Hawkins Map of Consciousness. If you don't know what that means, do some research or listen to the show because it's impressive and fun to learn about and it means something. Visit quantumupgrade IO and get a 15 day free trial. Enjoy. Every time I've had a stem cell treatment in the US I feel worked over. I mean, really bad. And it's for a long time. And it's worth it because I'm planning to live a long time. You do something on the first day, which is what I call blood washing. Tell me about plasmapheresis and why we need it.

So, you know, plasmapheresis has also been around for quite a while. It's an FDA approved process. And again, as I mentioned earlier, it's not really readily available at all as a preventive treatment. But recently the research is now really supporting Dr. Kipro. Dr. Convoys have published papers that document that by removing the plasma, that's the liquid part of your blood, 55% of your blood is this clear. It's supposed to be clear yellowish compound or fluid. And then the red cells and white cells are the rest. But as you age, okay, that plasma clear fluid, which is what surrounds your, your blood cells, including your stem cells with nutrients and removes their waste products, gets more contaminated year after year. Not just from your cells aging, the environment, micro bacteria, vaccines, everything that is suboptimal for the function of those cells is now surrounding them, limiting them from reaching their full genetic potential.

It's like if you have an aquarium and you never change the water, it gets a little skunky. Well, your blood water is the same way. Yeah. So you go through on the first day and you take all of those inflammatory factors out.

Yes.

Then when I had the orthopedic procedures, yeah, I was sore. We injected my knee. I've got substantial damage in both shoulders. This is why people tell you to work out two hours a day in order to stay young. Probably haven't figured out what happens when you do that. But what you're going to find out is if you do plasma paresis and then stem cell work, your inflammatory response is so much lower. So I come down here, now my blood's clean and you feel so much, just so clear after that. Then we treat the entire body, including all the reproductive stuff. I'm knocked out for all of that. So I have to feel it. And I've been awake for all those procedures before. Oh, don't want to do that again.

Right.

But as soon as that's done, now I have clean blood, and then we open up the blood brain barrier and we do the cognitive thing.

Yes. See, the sequence of events with what you just had is really important. And let me give you a major reason why. Plasmapheresis, we check your inflammatory markers, your HSCRP and some other cytokines prior to and after. And we've done this for a large number of patients. Your general body inflammation drops way below the norm ranges. This in itself is very positive for aging because inflammation is something that is a negative impact on everything. But also, we've now seen with some of the work, for instance, by Dr. Kiproff, that multiple other biomarkers of aging are also decreased. Stem cell functions better. A whole host of body functions are better. So the secret here is that's a key component also prior to getting back any stem cells, because you don't want to give back stem cells, either the ones you've already collected, or the umbilical cord, mesenchymal stem cells and put them into a pro inflammatory environment that's full of other contaminants. So the sequence of events of what you had really make the final impact of all these things dramatically better for aging. Your, Your cognitive ability, your. Your mental facilities are clearer, quicker. You have virtually no aches and pains in your body anywhere, which is like, I feel young again.

Yeah.

So all of this is a whole new approach. Instead of just isolated pieces in the puzzle, it's like putting a good portion of the puzzle back together.

Well, I know that a lot of listeners are saying, I want to do what Dave just did. So here's the deal. I put together a package of all the stuff I did, and you can save tens of thousands of dollars on it. And I want to be straightforward. I'm not a billionaire. I've done reasonably well for myself. I drive a 2014 Jeep. But I spend more on my health than I do on my vehicles or probably my rent, because I think that's the most important investment I can make. And yeah, I do rent my house too. So this is what I care about. And so if you're interested in this daveasprey.com clock, and this is less than half the cost of the procedures I've done in the past. But we're resetting the central aging clock. We're washing the blood. You don't have to Penetrate your fat or your. Or your bones. And it's so much more effective, I think in part because you stack it with hyperbaric.

So hyperbaric chamber therapy is something that's been a therapeutic approach that we've known about for years. But more recently we're now starting to see that by oxygenating the blood, that in itself is a major help with cell function, cognitive impact, and a host of other just general metabolic processes that it's from nutrition getting into the cells to the cells, waste products getting out. But also we now know that hyperbaric oxygen actually releases stem cells. So in essence, it's kind of like a mini stem cell treatment as well.

Wow. If you're listening to this going, that's way too expensive for me. This is coming. We're setting the standard for the future. And there's. For all technologies, there's always the ones that people over invest in. Like the very first handheld video cameras were $10,000 and they barely worked. And only crazy people did those. We're past that. I think that's what I was doing five years ago when I was injecting every joint in my body with stem cells in the US with all the painful stuff, this is not particularly painful. The benefits are there and the cost has dropped substantially since then. But if you're saying I'm still not there, I've had Dr. Christian Drupo from Stem Regen on the show as well. You can release more of your own natural stem cells with hyperbaric. There's supplements like that that can help you with it. The point of all of my work is here's something we now know about human performance, cognition, about aging. And since we now know this, what do you do that's free? What do you do that's very low cost. And what do you do that's expensive? And I'll do all three of those and tell you about them. This is the high end. And I like to make a comment.

People say I can't afford it. Okay. Particularly people in our age who are over 50, 55.

I'm sorry, I identify as my. As my measured age, not my calendar age.

Well, that's what I do.

I'm feeling triggered.

Good. What's your. What's. By the way? What is your extrinsic age?

Oh, man. My extrinsic age is 19 and a half years younger than my calendar age. So I'm about 30, 31, 32.

I beat you by just a few. Mine's 22 years below my center.

And your chronological age is 22 years older than me. Yeah, well, you're killing it.

Well, listen, I use, I'm an advocate of all these therapies, so I have access to them. And getting back to the key point is how do people do this for free?

Yeah.

There's a way to do that.

All right, what's that?

Okay. And frankly, this is what I did when I first had started this. Look, we all, at our age, we all have life insurance policies which you could borrow money from at no cost. For instance, you could borrow 12, $13,000 to get your first treatment and stem cells collected to reinsure your future, which is what we call bioinsurance. So my children are going to get $15,000 less 50 years from now when I'm gone. So what is that money really going to be worth? But I didn't have to really. I, I paid my premiums. I can use that as an asset to buy myself more healthy time.

Oh, that's interesting. Okay. I probably should get some health insurance for life insurance. I mean, whatever, Whatever. It's a good idea.

Yeah. So that's one of the, one of the little, if you will, biohacks that you can use if you want to jump into this. Okay. And if you want to do the whole stack that we've now done on you, that's another way of accessing that.

That's so cool. I like doing the stack because you're going to come down here, you might as well just do everything. And I can't say enough about what happens on the reproductive side when you do the injections. And you guys are also using pressure waves.

Shockwave.

Shockwave. Yeah. On it as well. Similar to what the Wasabi method is. And man, you feel very different and you see changes in size and performance even if you don't have ed.

Yep.

It's. It's also part of being young. So I've, I've seen dramatic results from that.

Yeah. So that has really been one of our more popular procedures with, I would say senior, middle aged senior men who their, their sex life and that's such an important component to a relationship has dramatically changed. So. Yeah. And so why not? I mean, this is technology that wasn't available, you know, a decade ago.

It's not just men, though. And you have the full procedure for women. Yes, I've had a lot of women on the show talking about female reproductive.

Yes.

Longevity. Yep. So you do a similar treatment for women where you're injecting stem cells vaginally and the results there are very similar the same. It just feels younger.

Yeah, exactly. So my recommendation is if you're coming here as a couple, don't look, just don't do one couple, because there'll be probably a little mismatched. Mismatch in activity levels.

Wow. So you come down, you wash your blood, collect your stem cells for life, and those are ones that we can enhance in the future. And then you make your central aging clock young again, which is the part I'm most excited about. The most groundbreaking here, you get your hyperbaric. You get stem cells injected in anywhere you have pain or injuries, and everyone gets those because you, oh, I'm going to play soccer when I'm 40. It's going to be expensive to play soccer when you're 40. Even when you're 30, it's expensive. Some of the things you treated are actually injuries from when I was 16. Yeah, yeah, yeah.

So one of the things I want to. Like you mentioned something about central aging clock and cognition, probably one of the most important things to keep in mind is as we grow older, the most. Probably the most important thing is to keep our mental acuity and our memory at its optimal level, because so many people at our age are just peaking in their businesses or they're creative writers, they're artists, and it took a lifetime to get there. So how do you maintain the mental acuity or mental abilities? This is, to me, the most important thing, along with maintaining your general physical activity levels. But if you maintain your body in a young state but don't have a mind at its sharpest, you're really missing one of the most important components.

Having a brain that. That just works effortlessly is one of the most precious things that I can think of because I didn't have it in my 20s. I had chronic fatigue syndrome. I couldn't remember anything. I remember thinking I would fire myself. And I was a CTO type of person at a big tech company. I'm like, why is it not working? And that feeling of helplessness and the fact you don't tell anyone because you don't want people to know. It's really common now, especially post Covid. So getting my brain back has been the biggest gift of the longevity practices I do. And you're an example of someone, you know, your brain is perfectly as good as it was or maybe better than when you were 30.

I think it's better be honest with you because, yeah, 30 is very tough. A tough time starting a practice, the stress levels. But yeah, honestly. And my goal is to continually enhance my cognitive ability So I can continue to learn and contribute and do the things I really love to do.

It's one of the reasons that I'm such a proponent of neuroscience. I have a neuroscience clinic and I spent six months of my life with electrodes on my head training my brain. Because, I mean, look, if I was in a wheelchair, that would horribly suck. But as long as I have my brain, I can still do the important things.

How you perceive reality is all based on how your brain processes what's coming into it. And the secret here is to allow your brain to not only perceive reality, but to look at it in a different fashion.

I actually don't agree with you.

You don't? No, Go ahead.

It's how your body perceives reality, because your body is pre processing reality before it hands it off to your brain. And your body is deciding which parts of reality it's going to show you. This is a distributed sensor system. It's our mitochondrial networks. They have a microsecond response time to the environment, but our brain doesn't get a signal for a third of a second, which means you have to have a healthy body to have a healthy mind.

Okay. But those signals still have to go to the brain for the final perception. They do, right? Yes. So I think we're both right.

We are both right.

But that's an interesting concept. Interesting. And you're right about that. And frankly, I didn't about it. So I like this because I'm learning.

Oh, well, I think you're a very knowledgeable, learned guy. So thank you. The, the models I've been working with more and more are how do I reprogram the body's perception of the world and the mind's perception of the world to have more peace, more focus, more consciousness? And something that was kind of cool this week here at RMI is you have to sit still and basically do nothing for an hour twice a day while the focused ultrasound is. And we'll put a picture of that in so you can see what it is. But it's shooting a beam in, but you can't move your head. So I've been meditating for two hours a day sitting in a chair with focused ultrasound. And then I'm in the hyperbaric chamber. And like, you can watch tv, but I really don't want to watch tv. So I've been meditating for something like four or five hours a day because I've been doing longevity treatments that required me not to move my head. So, like, wow, I have extra oxygen, extra stem cells. My hypothalamus is working better and I'm just downloading things. So it's been a really resetting week for me anyway.

That's great. You know, I'm a big believer in meditation. And as we discussed in the past, the Monroe Institute centerpoint Research Center, I've been involved with them in years ago in. What's the real impact on meditation, aside from making you feel better, is it dramatically drops your stress hormones.

Yeah.

It actually elevates your. Your, for instance, your testosterone. It elevates your dhea, which is one of them. It's. The human body can literally reset itself from a hormonal point of view if you change your mindset. Which is really why a lot of these Tibetan monks or yogis live very longer, healthier lives, because they're actually, if you will, biohacking their brain with the body's own ability to do this. And that directly feeds into what we're doing at rmi because we believe our bodies has an innate ability to regenerate itself if we just help it a little bit. Because this is a regenerative system I talked about with stem cells at your late 40s. You start to lose those stem cell numbers and function. And that's really the basis of your regenerative system.

It is. And it's. It's a challenge because I am not going to meditate for two hours a day because I have stuff to do. And that's why I can get decades worth done in one week. And I could also spend four hours a day on longevity practices that don't work very well per minute. Or I could come down to RMI and I could do decades of longevity work in five days, which is. This has been sort of the dream. I've been touring the world doing all the longevity things. But to be able to stack it like this, especially because when you stack it, it drops the cost per procedure to make it much more accessible. I'm pretty blown away. It's been a very potent week for me.

And so not only is the cost much more acceptable, but the synergy or the impact of those treatments together are so much more than if you did them separately. So it's really. I think this whole concept of putting this all together gives you a dramatically more effective impact on the aging process in your body.

Pretty profound stuff, guys. Daveasprey.com clock that way you can reset your aging clock and do all this other stuff. Or maybe you're just learning about stuff that you can do that doesn't have anything to do with coming to Costa Rica. And it's like I said, a three hour flight, so this was very accessible. Now let's talk peptides. You know so much about peptides and longevity. What are the peptides that have you most excited?

You know, I'm going to go back to the story about heterochronic parabiosis and you know, young blood and, you know, young serum. You know, we know that in young people there's certain factors that really make older animals or older people supposedly. Okay, so what are those compounds? Okay, and what are those, what are some of these key peptides or proteins? Right. So the latest research really is about four key peptides. First of all, folistatin. We all know we hit our 40s, we can't build the muscle we used to do. We work out harder, we build less muscle. Foley statin inhibits myostatin, which is something we start to produce in our 40s, which inhibits muscle growth. But Foley setin does other things. It dramatically drops inflammation. It actually may be actively involved in some cognition enhancement. But we mainly see the muscle. You know, the muscle loss is a big problem in older people because of what we call sarcopenia. Older people get lose so much muscle they can't even get out of a chair or be independent. So I think follistatin is going to. And by the way, Follistatin is one of the few new peptides that's actually being approved in the US for now. Childhood muscle wasting diseases.

Interesting.

So that's now approved. It's not out there as a treatment everybody can have yet, but we're going to talk a little bit more in a few minutes about how that might happen shortly. What's the other protein? Clotho. Now my favorite.

I wrote about both of these, especially Clotho, in my book, and you couldn't buy it anywhere.

Yes. And so now that's, that's becoming synthesized and Clotho, why do I love that? Is cloth is one of the most important things for neural regeneration, cognition, and you and I are big fans of that. But it also enhances cardiac function, renal function, a host of other things. So these are compounds I'm sure are in that little young mix in the blood that is impacting older pigs. What else? Okay, so we're looking now at GDF11. GDF11 may turn out to be, it's my personal opinion, one of the most important peptides because GDF11 has a unique ability to repair damage to your stem cells.

Wow. Which means de age those.

It actually and the research is pretty strong to show it actually is restoring the DNA damage so that that stem cell quality improves.

Can I buy GDF 11? Now?

There are certain places on the web that say they have it for sale and you have to be very careful. But yes, there are. And again, I don't know about the quality of those things, but assuming it's.

Good quality, how do you dose GDF11?

Well, see, that's another thing. You can, and I'll mention one person who's been involved in that for the last few, a number of years and actually been collecting data, Steve Perry. And you can go to YouTube and see his data, which will blow your mind away. That arterioelasticity is decreased, blood pressures down, cognitive functions better, a whole host of things. It's actually anti cancer prevention.

Wow.

So this seems to be one of the things that we're looking at at the research level. And by the way, I don't know if you know, you know, I'm on staff at David Sinclair's lab at Harvard at the Paul F. Glenn center. And David, David and I have been, I guess for over almost 15 years able to have conversations about where the future may be going. And again, these are some of the things that I think he's very knowledgeable about.

He's been on the show, I think a couple times. Yeah, yeah.

So what else? What other peptides? PGC1 alpha.

Oh, let me take a. Oh. Does nicotine in pharmaceutically extracted raise PGC1 Alpha? Oh my gosh.

So I, so I heard. Now not only does it raise that, but what does that do is now we're looking at the bioenergetics at the cellular level.

Yeah.

So we all know that we lose our mitochondrial number and the ability of those mitochondria to make more amounts of ATP, which are what drive the cell. It's a cellular fuel. Right. And we know about nmn, we know about nicotinamide riboside, we know those things help too. But PTC1 Alpha actually helps with mitochondrial biogenesis. Okay, so why is that important is because we now know that if we make less ATP, our cells, our stem cells and body cells aren't going to work. So when you put these four or five peptides together, okay, we start to now open another whole doorway to where the future of longevity aging medicine is going. The question is, how might we deliver those instead from an oral pathway? How could we deliver those in a long term manner and perhaps how could we even enhance the level of those things that even a young person would have so we function even better. So I'm going to leave that up to you and then I'll give you my impression.

It sounds like a mini circle problem and it's funny. Mini circle. I'm an advisor to the company and a shareholder. This is the gene therapy company. And guys, I did a podcast about that and I've had the full stand gene therapy and this is one thing, so small injection to tell my body to make more of those. And if you, if you go to daveasprey.com clock you get info on all this advanced longevity stuff that I'm talking about. And I'm a huge fan of them because I'm also registered to be in their Clotho trial.

Interesting.

Which hasn't started yet. But I'll actually make my body create more Clotho than it normally would, which is going to enhance my brain and make me younger. But you have a different idea, don't you?

Yes, I do. And again, I'm always trying to think of if I was in the future, what would be available to me that's not available to now.

Yes.

So I kind of like go into a state and kind of try to visualize what might be the next big thing. And I've had the opportunity and pleasure to meet the head of Bioviva, which is her. The CEO is Elizabeth Parrish and she's.

Been on the show as well.

Yeah, there you go. So I think the. What Bioviva is doing is potentially going to be one of the biggest leap forwards for wellness, extended health span and productivity for humans. But I recently had had a couple conversations with her about how do we do, how do we take what you're doing and make it better? So my initial thought is why this, which is gene therapy now, this is different than plasmids, which is many circle. Yes, no. And they're both very effective. Now the question is how? What would be a potential way of putting this? Augmenting these key genes that we know are really effective in enhancing youthful function in many ways. Why wouldn't we put them in stem cells? So that's where my present thought process is. And I've had the pleasure to speak to Liz Parrish about, gee, what are your thoughts are. And this is somebody who's open minded, looking for the future, focusing on humanity, focusing on what can we do to make life for human beings in the future better. So we'll see where that goes.

Do you think it would be ethical to offer these treatments to regulatory authorities who are trying to stop us from having access to them.

Well, I think it would be super ethical. But I could also, I can tell you this, they're not going to accept it. So there are places, a few places in the world that are starting to like jump over or create legal locations where those people who want to be involved in cutting edge therapy that has some level of credibility and safety already to it to be the real first group of people that are going to try to help prove that these things are effective and safe. And I think that's what we need to look for.

Well, Costa Rica is definitely putting itself on the map and Abu Dhabi has a great track record as well. And what's going to happen. And I want world leaders to listen to the show and there's probably a few. If you don't just stop getting in the way of the kind of work that thousands of longevity doctors are doing, the most successful people who pay most taxes and control industry in your country will leave your country because we can live longer. And why wouldn't you just allow this forever? This is not for you to regulate. There, that's from psa.

I'm glad you got your opinion.

Now what I'm seeing is in the future I'm planning to keep doing gene therapy and I know there's about 10 different targets with mini circle to make the existing cells in my body create more of the compounds. And I want the stem cells that you've banked for me to get edited with this new technology you talked about so that when I introduce those stem cells, they're going to be able to go in and these are pluripotent stem cells that can actually turn into tissues in my body that are built different that can do things that my normal tissues wouldn't do.

So let me tell you what in my vision of this all may look like and highly likely to look like. So we collected your stem cells. You're at a certain age. I'm not going to fill your age.

No, I'm calendar wise, I'm 50, 51. But I was kind of joking earlier. I identified as in my mid-30s because that's all my data says. Yeah. So. Yeah, but that's what the calendar says.

Okay, so now that you got your stem cells collected, you could literally after 50 ish is really kind of the, the cutoff line where we're thinking we need to start giving you back your stem cells to kind of mitigate this deep line drop in quality and quantity so that instead of seeing this decline, we're going to see this flatten out. The next step is, and this is what we're really working on to get clinically to patients very soon, and it's our hopes anyway, is that we can take those stem cells that now have the activity level of a 50 something year old person and revert them back to a 20 or 30 year old. So that means those stem cells now are going to be able to repair. You're going to have a stronger immune system, you're going to have healthier blood vessels and your organs are going to be able to repair the cells that have become non functional more efficiently. Now that's a major leap forward in keeping people healthier longer. But what's the next step is if we were able to not only quotes, reprogram your stem cells. Okay. But then add to them the key genes where we're now seeing as being involved in the most important aging pathways. Clotho, Foley's 10, PGC Alpha 1, GDF 11, H Tert, which we didn't mention before.

Let's talk about that.

Yes. So you know, Bill Andrews is probably one of the, probably the, the leading expert in telomerase activity and the effects of telomerase and a very super bright and dedicated individual that was on the show years ago.

I knew him from when I ran a longevity nonprofit group in the late 90s.

Right.

Yeah.

You may want to get him back on. The advances in this are also amazing. So what does HTTP do now? First of all, most people when they talk about telomerase or they take tablets with TA65, you have to understand that there's only two pools of cells that make telomerase in your body, your stem cells and your germ cells. So the rest of your body cells don't make telomerase. So the secret here is, and it seems that nature knew what cells to pick that are most important, your stem cells are your source of regenerative power. Okay, so but every time your stem cells divide, your telomeres get shorter, right? So they get less and less effective or they can make less copies and then now they're accumulating DNA damage. Oh, didn't we talk about GDF 11 about repairs of DNA damage and stem cells? Oh yeah, now we're talking about H Tert, which has been documented to the length in your telomeres because it enhances telomerase. So guess what? Now we can allow your stem cells that you have to make more copies, longer. We could maybe fix the DNA damage that decreases their quality, but at the same time, we can even give you back greater numbers of what you had closer to what you were born with or had when you're your 20s. So the regenerative system might be rebooted.

Wow.

So HTUR also is something that I think has already been documented to lengthen telomeres in humans.

And do you think we're going to do that with gene editing?

I think it's going to be. It's already been done with gene editing.

Oh, wow.