Alzheimer’s Prevention: Unlock Brain Health with Keto & Fats - Dr. Mary Newport | 1192 | Dave Asprey

I'm just profoundly grateful for my elders who, who mentored me that way and showed me that they could do it. I'm like, well, if you're 80 and you can do it, I could probably pull this off. And so it's, it's your job. It's my job. Everyone listening, it's your job too. If you know this stuff and you see someone with Alzheimer's, like, maybe you should listen to that episode, maybe get a book.

Some of them will, will listen to you and they'll do it. And others will say, that's just too simple, that is not possible. A lot of doctors, you know, react that way. They won't even take the information from their patients, you know, which is really sad.

Yeah.

But then there are other open minded phys who are listening and they have patients that improve and then they start telling their other patients about it.

You're listening to the Human Upgrade with Dave Asprey. You're listening to the Human Upgrade with Dave Asprey. The episode today is something that I'm really excited about because it is with, I'm going to say, a hero of lipid metabolism. Now if no one has ever said hero of lipid metabolism before, that's because it's hard to even explain how important fat is for the way life works. Your cell membranes and a lot of your hormones, they're made out of fats. And different fats do different things. And we have this really simplistic, you know, Readers Digest food pyramid way of thinking, well, fat is good, fat is bad. If you're going to build a house and said, well, bricks are good or bricks are bad, you'd be kind of dumb because you might want to use cement, you might want to use wood, you might want to use metal, you might want to use whatever. They're all building materials. And you use the right building material for the right job. So simple is good. Unless it's so simple that it's dumb. And that is where the, the main discourse around fat is. So when you get someone who's spent a lifetime looking at what do different fats do? What are the role of these in the brain, in biology? I don't think you can get someone who is more studied than Dr. Mary Newport, who's our guest today and she has a new book called Clearly Keto for Healthy Brain Aging and Alzheimer's Prevention. And I wanted to interview her because she's a legend in the field. And also I went through more than a thousand studies on Alzheimer's disease when I wrote Head Strong, my big cognitive enhancement book, and in my longevity work in Superhuman, one of the big four killers is Alzheimer's. If we can just fix it's so we don't lose our minds as we age, we would have a population of people who have wisdom because their brains work. And if we fix their mitochondria, then they have energy and all of a sudden we have people who are really well equipped to help the world be a better Place. So, Dr. Mary Newport, welcome to the show. It's an honor to have you.

Hi, Dave. Thank you. And everybody listening. Thank you for inviting me to come. I really appreciate it.

It is. It is my pleasure. I mentioned your most recent book, which is the Clearly Keto book, but you have three others as well, and they probably your first book was one of the ones that really helped me crystallize some of my thinking behind the bulletproof diet and things like that. So it's. It's just cool to be able to chat now.

I have a third edition of it that came out in the fall 11 years app. No, 12 years after the first edition came out.

Oh my gosh. The other thing I love about. About your work, the reason I want to talk to you is my first book was called the Better Baby Book and it was how do you have a child without autism or Asperger's? Because I had that. And yes, I'd say had because I. You can heal it. And yes, there's some work to be to be done. Like some of the functional movement things are a little bit. A little bit of work, but overall you can, you can fix things. So you spent 30 years working on newborns and then all of a sudden you switched over to Alzheimer's. Why?

Right. Well, it all had to do with my husband. My husband Steve. He was an accountant and he worked at home for my practice. I worked in hospital strictly. He took care of our children. I had a lot of emergencies and. But when Steve was only 51, he started having memory problems that were. Got serious fairly quickly. He stopped remembering if he'd been to the bank of the post office. And, you know, he was very depressed. He knew something was wrong. He had known for a few years. I found out later. I didn't realize it, you know, for a while, but he just kept getting worse. He was diagnosed with early onset Alzheimer's in 2004. And this is like at the opposite end of the spectrum for. From where I had been focusing my career on at that point. And it was just, you know, a horrible thing, you know, we thought we'd retire, live to an old age and then, you know, retire together. And it just didn't look like it was going to happen. The average person lives about seven years after a diagnosis of Alzheimer's, and he was only 54 at that point.

Wow, 54.

Early onset. Very early.

Given all the research you've done now, why do you think your husband got Alzheimer's at an early age?

I have a few ideas about that. 1. There are something like more than 6,000 studies now of various infections linked to Alzheimer's disease. And he had really a lifetime of having fever blisters on his mouth. I mean, like repeated outbreaks. It's a herpes simplex type 1 virus. And there have been hundreds of studies just on herpes simplex connecting it to Alzheimer's. And they've been able to show, like in mice, for example, that infecting them with herpes simplex will induce formation of plaques and tangles in the brain, which are the hallmarks of Alzheimer's disease and many other studies. So I really felt like this was possibly a trigger. And when he was 29, he had an outbreak of it around his eye. And he was really sick. He was sick. He couldn't sit up, he, you know, couldn't eat for a week or so. And I was really worried about that. You know, I took care of babies that were born with herpes simplex virus infections and they were severely brain damaged. It was just a terrible thing. And I was taught that the eyes are a portal to the brain. So if you get an infection in or around your eye, it could get into the brain. And, you know, some people will develop herpes encephalitis and it travels in the same locations of the brain that Alzheimer's does as it progresses. And so I really feel like that is the likely trigger. And what lit the match, I think could have been a medication called Vioxx.

Oh, interesting. What does Vioxx do?

Yeah, so Vioxx was a very potent anti inflammatory drug. It was used mostly for arthritis. And around 2000, 2001, Steve was taking this for about a year, a year and a half, and he was. He had his foot. Feet would swell if he. He would be out in the yard working, landscaping, and then his foot would swell tremendously and be really, like extremely inflamed. We found out later it was gout. It's just not the classic presentation. Usually you think of a toe, but this was this whole foot. And he responded really well to Vioxx. So he was taking this for about a year, a year and a half. And I later found I'd started looking for different connections, things he had done. And Vioxx had been taken off the market in 2004. So he was on it around 2000, 2001. And the reason they took it off the market was because of several Alzheimer's studies that were done. And two of the studies, the people who got Vioxx, had a much higher rate of dying from heart attacks. These were people with Alzheimer's. And then there was another study that had been done of people with mild cognitive impairment, which can progress to Alzheimer's. And they were hoping to prevent it. There's a lot of inflammation in the brain in Alzheimer's. So they were, you know, the people that got the drug, it actually accelerated their progression to Alzheimer's. And. And they would start seeing people convert from mild cognitive impairment to Alzheimer's with even at four months on this drug.

Wow.

Yeah. And Steve was on it for a year, year and a half. And this was right around the time I started noticing strange things he was doing, you know, memory issues and shuffling papers and missing tax deadlines. He was an accountant. He'd miss, you know, a 20 minute quarterly tax return would take him days to get done, which was just not what had been going on before that.

Right.

You know, it was really serious. And, you know, so I think those two things factor heavily into it. And our diet, too, I think may have contributed because we were on what I call the convenience food diet. Both of us, I weighed about 60 pounds more than I do now while we were eating this. And it was a low fat, you know, we were told to eat low fat and. Which means high carb. You know, if you're eating a typical American diet and eating a lot of box foods from Sam's. I really wasn't into vegetables, you know, I had a little less, and corn, you know, and so our diet was just terrible. We were going to fast food places two or three times a week and eating out more often. And so, you know, two years before our intervention, ketogenic intervention happened, I came across an article about Alzheimer's and people with Alzheimer's who had eaten the most Mediterranean like diet lived on average four years longer than the people with Alzheimer's who ate the least Mediterranean like diet. And that was the first time I ever conceived that Alzheimer's could have anything to do with nutrition. You know, that nutrition might be a factor. I mean, we were told it's not what you eat. You know, it's not what you eat, it's not this, it's not that, you know, they didn't know what it was, but they were, you know, pretty clear they didn't think it was what you ate. But this article suggests that otherwise. So we drastically, you know, changed our diet over to a whole food Mediterranean style diet which, you know, greatly reduced our carbohydrate intake just by default from what we were doing. And then I started kind of looking into this low fat idea and really not finding enough justification for it, it, for why we should eat a low fat diet. I think that was really why I got so heavy. I was always eating skim milk and cereal for breakfast and cereal for snack, you know, for a snack in the evening. So, you know, Steve, he, he still progressed and it's hard to know if it slowed it down or not, you know, but it was definitely a healthier diet. So I'm still on it today. You know, we stayed on it and, you know, I've been eating actually a low carb, you know, keto version of a Mediterranean diet, you know, which is what I talk about in my Clearly Keto book.

Are you always low carb or do you cycle in and out sometimes?

I am mostly low carb. Every now and then, you know, if I go out to eat, I might, I don't ever buy bread, but some restaurants have really good bread. So I might have, you know, a slice or two of bread or something, you know, if I go to a restaurant. So I cycle a little bit. But I would say maybe every couple weeks I might take a day or two where I kind of loosen up my regimen a bit. It's helped me maintain my weight too, which is great. You know, it's really hard to keep that weight off. And I have been able to do that, you know, for, let's see, since 2006.

It seems to work better. I mean, I, I went on the Atkins diet, the original keto, in the late 90s, and you could lose, you know, you lose £40 and then. Yeah, and then you plateau and you can't lose the other 60 no matter what you do.

Right, right.

And then I, I would go to these. I remember Jimmy Moore, I went on this low carb cruise where these were people who are kind of more in that, that extreme keto side of things. And the rule was if it's not a carb, you can eat it. So it's fine to add all the chemicals, it's fine to eat bad fats. You just can't eat any carbs. And there was all these morbidly obese people there. And if that triggered anyone listening, guys, I was a 300 pound guy. So, yeah, it's morbid. Obese is a medical term. And if. Yeah, and if that describes you, you. Thank you for listening. You can change it. So. And I'd ask him to say, it doesn't look like this is working, like, in a polite way. I was there as a speaker, you know, there's no judgment. And universally they're like, oh, are you kidding? I used to weigh 600 pounds and I only weigh 400 pounds. This stuff works. The problem is I'm eating 15 grams of carbs, and if I could just get down to 8 grams of carbs, I know I'll lose the other hundreds of pounds. But cycling, this is one of the reasons I wrote the bulletproof diet. The type of fat matters and then cycling matters so that you occasionally get some carbs for insulin sensitivity. So it's interesting to hear that you're cycling about every couple weeks.

Yeah, well, I tend to stay. Try to stay under like 40 or 50 grams a day. That's my normal routine of carbs. If I really want to go super keto, I'll. I'll shove it down to under 20. But I usually kind of stay in the 30s, like maybe 29 to 40 or 45 grams a day, you know, so I'm kind of in the range of what you would call mild to moderate nutritional ketosis.

Yeah.

As far as how my ketone levels are.

And you use mcts, which gives you a boost. You can have carbs and eat MCTs and it still works, right?

Yeah. Coconut oil and MCT oil. I combine those. I actually have a mixture that I make that I gave to Steve, you know.

Yeah, that's the original Alzheimer formula there. And people. You still sell that, right?

Yeah, yeah, there's a company that sells it.

And, you know, the good news is that, you know, there's availability of it and anyone out there, I mean, you can get MCT, by the way, C8MCT. I wrote about that in, in my book, but we didn't have the studies yet. But that is the one that works best for raising ketones. You can mix it with coconut oil or any other fat you want and see what happens and it might be good. There's a pretty good chance you've heard about GLP1 because popular drugs like Ozempic and Wegovy are manipulating this hormone that your body makes. It's because GLP1 plays a huge role in your metabolic health. And as you age, your body makes less of it. Lucky for you, the folks at Pendulum created a probiotic full of science backed strains that can help your body produce more GLP1 naturally. Based on pre clinical studies, GLP1 probiotic by pendulum helps curve cravings and, and the numbers that back it are impressive. In a six week survey of 274 people, 91% of people had less food cravings and 88% reported reduced sugar cravings. That's game changing, so give it a try if you'd like to maintain a healthy weight and metabolism. Try it now@pendulumlife.com with code ASPREY20 for your first month of GLP1 probiotic or any Pendulum formula. I want to talk more about Alzheimer's and herpes before we get into other effects of just keto on cognitive function. Other stuff we're going to talk about. Yeah, there's definite evidence that at least some types of Alzheimer's are driven by infection. I think you know Dr. Dale Bren as well, right?

Yeah, I do know. I, I do know him. I've met him at a couple conferences.

He's just a great guy, just very kind and, and giving and humble and he was on this show and he wrote his book the End of Alzheimer's. And for a, you know, quote, real doctor, you know, practicing in a, in a big institution to say something that audacious and bold was kind of a risk. But he was the first guy I met who said look, infectious Alzheimer's is one type, they're toxic metal, there's toxic mold and then there's I think a metabolic, there's a couple others. But to subcategorize them was I think a great breakthrough. And he's had evidence where he's reversed people and you've also had great evidence for what you're talking about saying you can fix the metabolic things when it comes to herpes. I just feel a moral obligation to, to share this for, for listeners. In my, in my twenties I started running a longevity nonprofit research and education group in Silicon Valley. And my mentors were the legends in the longevity field of that time. And my, my members in this organization were 70, 80 years old and they asked me to be president of it when I'm in my 20s because I was the only person under 50 in the room. And my primary biochemical mentor was a guy who has been on the show named Steve. Folks. Steve wrote a book that's available, I think for free download called something like the End of Herpes or her or there it is. Cure herpes with bht. And BHT is a synthetic oil antioxidant that's used in food packaging to prevent oils from going rancid. And throughout the 80s, you might remember this, this is a little bit before I was into longevity, but I knew a lot of people who knew about it. People would take BHT to inhibit breakdown of fat in their cell membranes. And it was considered a longevity drug. And it's almost free now. It turns out at very low doses it can be a mild endocrine disruptor. And if you replace something like half of your food for a year with it. I'm exaggerating a very, very high doses. It might be pro cancer, but at the 300 milligram kind of dose, it stops all, all lipid encapsulated viruses, including every kind of pox and herpes, all the different simplexes. So for about a dollar, within three days, you can make a cold sore or a fever blister or a herpes outbreak dry up and stop.

Wow.

And it's not a thousand dollar drug. It's not highly profitable. And I know a lot of people with shingles, they're just in charopine. Like just rub something like put it in some lotion and rub it on and take a couple capsules and a few days later like, I'm fine. So I feel like everyone who has herpes the first time you have an outbreak and I think half of people have herpes virus in, in their, in their systems if they, whether knew it or not. You could just take a little bit of this stuff on occasion and net net it seems like a good idea. And this is what Steve, Steve taught me and he's been publicizing this for years. So you can stop smallpox, not that we have that running around. Monkeypox, chicken pox, some sort of new invented pox that'll make some government guy the next billion dollars. Pox. All of the poxes, you can, you can stop them and you can stop herpes. And it won't go away permanently. It just cannot replicate at all. And that means it stops replicating and you just for a brief period of time. I know people have done it and never had another outbreak. Other people do it when they have an outbreak, but the outbreaks become less and less. If this knowledge was out there and your husband had access to it, it would have been worth it for him to know that. And it drives me crazy.

Yeah, I had not heard about that at the time. We were told that lysine was effective and you know, so he was getting lysine all the time. He would still have some outbreaks.

Yeah, lysine helps and arginine makes it worse. Yeah. And but by the way, I've never had, I've never had a problem with herpes. I used to think I did because I was getting like autoimmune little white nodules. Those are actually food allergies. But on blood tests, all I don't. But I know a lot about this because I've mentored so many people and because one of my most impactful mentors taught me this stuff. So I just want to pass it, pass it on.

Yeah, no, I appreciate that. I mean, so we're going to. That coconut oil was the intervention. The first intervention was Steve. And half of the coconut oil is lauric acid, which is C12. And lauric acid is also highly antimicrobial.

Right.

So I think that factored, it factored into controlling, you know, and helping him improve. It kills all of the viruses in the herpes family. It kills bacteria, fungi, spirochetes, like the Lyme spirochete, which is, it causes symptoms very similar to Alzheimer's. It's a very pro, you know, common infection. I think about a quarter million people in the US have this infection every year. And it, it kills that. Spirochetes are in the same family as syphilis. I mean, spirochetes cause syphilis and syphilis is known to cause dementia if it's not treated. So after we started coconut oil with Steve, it was really rare for him to have an outbreak. Over the next eight years he had four tiny outbreaks and it was usually he would have a cold or some other infection and then he would break out with like a small fever blister. He used to have a big fat fever blister every two or three weeks before that.

Wow.

So it really did help control it. But I'm definitely going to take check out BHT too.

It goes so well with a high fat ketogenic diet too.

Yeah, yeah.

And so I know, I know some, some families with kids who get chickenpox because their parents believe that you might only want to vaccinate for life threatening illnesses. And chickenpox is not life threatening.

Not usually. If you're get it as an adult, it can be really serious.

Yeah, that's true. Which is probably why you might want to get it as a kid. But you know, that's, that's old way of thinking and I, I would never ascribe to old way of thinking. But anyway, I know some people who, who do that and they're like, well, what can we do? And well, the answer is you want the immune stimulation effects of it. So after the first wave of little itchy whatevers, you have to get some bhd. They don't have to go through seven waves of little things and they get, they get the lifelong reduction of, of their respiratory illnesses. It turns out that having an exposure there, a brief one that the body handles, probably has some benefits that aren't talked about. And I'm not saying as you should go out and you know, get chicken box on purpose or not. I'm just saying that evolutionarily there might have been a reason it was there and if it did happen, for whatever reason, you can reduce the severity of it very, very quickly. With BHT and Vani Hari, who's been on the show, the food babe, who's a friend, that's when I talked about business a lot. You know, she's like on a war path. Get BHD out of packaging. And she probably has a point because very low dose bhd, it has an endocrine disrupting effect. It's a very low effect. Yeah, I don't worry about BHD that much compared to BPA and all the other endocrine disruptors, atrazine and microplastics. But the risk of herpes long term and what it does is higher than you think. So if, if anyone listening has that going on, the book is free. Steve Fowkes. F O W K E S. Listen to my interview with him. Google Dave Asprey, Steve Fowkes. You'll find it or the book's free and it's. What's it called? The PHT book is what it's called now. So there you go.

Yeah, well, relative to the herpes simplex virus, the shingles virus, which comes from chickenpox, herpes zoster. Zoster virus. There are studies now, really large epidemiological studies that were conducted in the uk, two different big cohorts that they had and they found that people that got the shingles vaccine to prevent shingles were. It was much less likely, it was maybe 27 or 30% less likely to develop dementia and people had not gotten the vaccine. And then there was another study that showing that there's a treatment for shingles called acyclovir and balletcyclovir is a close relative to that, that penetrates the brain better. So people that had shingles and got treated with this particular medication were also much less likely to develop dementia.

Interesting.

So avoiding these infections and that her whole herpes family is pretty serious. Epstein Barr virus has been associated, and that's the one that causes mononucleosis has been associated with multiple sclerosis.

Ms. And also with just chronic fatigue syndrome which I had. Mine was caused by toxic mold. But yeah, it's a, it's a very complex bundle and even, even your husband's gout that's linked to oxalate and it's linked to mast cell activation and these viruses activate mast cells all over the place. So we get these things. What's the chicken? What's the egg? Metabolism is the chicken and the egg.

Yeah. Yes.

And that's why in your work, in your books on ketones and brain health and all like, let's fix that. And then these other things, the body becomes more resilient.

Yeah. Yeah.

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Okay. So, yeah, this is something I've been looking into and reading about for a long time. So, Steve, for those who don't know, he had a big improvement when we introduced first coconut oil into his diet. And the reason I did that was because it contains medium chain triglycerides, which is. Are in medium well MCT oil. Medium chain triglyceride oil is extracted from coconut oil. And I had come upon a press release about a medical food that was going to come out about a year later. And it was C8. It was the MCT. C8. And I knew what MCTs were because I'm a neonatologist. We used to add them to the feedings of our tiniest preemies. These were babies under 2 pounds and, you know, to each feeding, and they would get home faster and they would thrive. You know, when you would give this MCT oil and then they started adding it to premature formulas and then newborn formulas. And if you look on pretty much any commercial infant formula, you'll see coconut oil or palm kernel oil on the label. Even now, you know, because they're trying to provide these medium chain triglycerides that are in human breast milk. So that's why they include coconut oil in infant formulas to try to provide these fats that are in human milk, but they're not in other common oils or not like soybean oil, olive oil, peanut oil. They don't contain any of these medium chain triglycerides. You know, so I came upon a press release and they had done. The company that was coming out with the medical food had done two studies. One was a pilot study. They gave 20 people on one day a placebo. On another day, they got C8MCT. And nine out of 20 people had an improvement in their cognitive score compared to the day that they got a placebo. And then they did a long study. It was. They tested them at 45 days, 90 days, and some stayed for six months. And it was 152 people. And they found that nearly half of them also had improvement in their cognition and that it was sustained, you know, over this period of time that they were in the study. And this was so interesting to me because none of the drugs for Alzheimer's ever have claimed that they improve cognition. They only claim the slow decline.

Yeah.

So. And Steve was on a couple of them at that time. He was on Aircept and Namenda, you know, at that point. And he was declining you know, he was declining, nevertheless, never saw any change or improvement in him from that. So, you know, he happened to be trying out for two clinical trials two days in a row. So it was a really interesting coincidence that I happened about the press release. I was looking for the risks and benefits of the two drugs he was going to try out for. They were both drugs that would remove plaque from the brain. And I happened on a press release about this medical food that was going to come out in about a year about these studies, and I was able to find a patent application. And that's when I found out about insulin resistance as being a major contributor to Alzheimer's disease. And the thing about MCT oil and the coconut oil because of it, is when you consume, you know, mcts, your liver will convert part of it to ketones no matter what you eat. And ketones are taken up and can bypass the problem of insulin resistance. So with insulin resistance, there's trouble getting glucose into the brain and into brain cells. And cells need fuel. Brain cells are really active. They need fuel continuously 24,7. But ketones don't require insulin to get into the brain or into cells, and they could bypass that problem. And so that was their theory, you know, of why they came up with this medical food, this mct, all medical food. And now they had studies showing that they did see improvement and in almost half the people that took it. So, you know, I was really kind of blown away. And I was familiar with these ideas, you know, they talked about, you know, during starvation or fasting, prolonged fasting, you know, after 24, 36 hours, you use up the stores of glucose in your liver, and then you start breaking down muscle. If you didn't have fat, but instead we start breaking down fat. And most of our organs except the brain have access to fatty acids that can act as fuel. The heart loves fatty acids, kidneys love it, but they don't cross into the brain very well. But ketones do cross. And so when you're in the starvation or fasting phase, some of the fat that is presented to the liver will be converted to ketones and provide fuel to the brain. And if you're on a really long period of starvation, we're talking 10 to 20 days, ketone levels will get extremely high and be able to provide about two thirds of the fuel to the brain. And there's still some glucose. But the body's capable of making glucose from proteins and from the. The glycerol part of the fat, it can be converted to glucose, you know, so the brain will still have access to glucose if you're as long as you have fat to burn. So anyway, this thing about insulin resistance, what they talked about was that it was present in people they had studied, done autopsies of brains of people who had died with Alzheimer's. And these were people that did not have type 1 or type 2 diabetes, but they found that they did have insulin resistance and insulin deficiency in their brains and that this was in the area where Alzheimer's starts and that it progressed through the brain, worsened steadily as the disease progressed. You know, so they were able to show that insulin resistance is a big part of this problem. And, you know, this has been like, known since the 1980s. They do FDG PET scans. These are glucose uptake PET scans. And they've shown that people with Alzheimer's and people that are going to get Alzheimer's can have this problem 10 to 20 years before they ever develop symptoms. You know, so you might already be on a track heading towards Alzheimer's because of this insulin resistance problem in the brain long before you have symptoms or aware of it.

You know, I was on that track.

Me too, me too.

I'm very firmly off this rack now. Yeah, the data, one of the things I came across both for Alzheimer's and also just for cognitive enhancement in general is nasal insulin. So it's nasal spray. And I mean, you take a little, a little thing like, like this, this is, if you're just listening, it's just a little meter dose spray bottle and you put it in your nose and you spray it and you can do it once or twice a day. And it directly affects glucose uptake in the brain and it's something that helps with early onset Alzheimer's. Kind of like treating type 2 diabetes with insulin. You don't necessarily want to rely on it, but it's better than having Alzheimer's.

Yeah.

And from a cognitive enhancement perspective, if you have no metabolic disregulation and you want to just be dialed in, you're going to meditate and download your next whatever or you're going to just work on a really focused project where just full presence and openness is required. Small amount of nasal insulin is a very potent nootropic. It seems like it's probably good for you. What do you think about that?

There have been a few studies of it and at Wake Forest, Dr. Suzanne Craft and her group have been studying this and they, their pilot studies look really good. One of their longer studies, it didn't show as much benefit. I think as they hoped that it would. And I kind of have some ideas about that. Number one, if you're still eating a poor diet, you know, high sugar diet, you're going to perpetuate the problem of insulin resistance. And I think it would be ideal to try to reverse the insulin resistance, you know, by eating a healthier diet. The other thing, too, I wonder, you know, the way it gets in. There's these little perforations in the base of the skull, and it can get up to the brain that way, the insulin. But I wonder how well distributed it is throughout the brain. So that's one of my questions about it.

I don't know either.

Yeah, yeah.

One of the other longevity therapies that I do specifically for Alzheimer's and just for general health is I take a microdose Cialis. Now, Cialis is a erectile dysfunction drug at full dose. You know, you use it for. For sexy time. But we're talking 6 milligrams, which is a very, very low dose to increase blood flow in the brain.

Yeah.

In my case, I know I need that because of all the health problems I used to have. And when I did my first scan lightly below normal levels through great effort, and I'm actually doing things to keep my blood.