Biohacking in Space: Prioritizing Prevention to Live Forever with Alan Graves | 1081 | Dave Asprey

You're listening to the Human Upgrade with Dave Asprey. Formerly Bulletproof Radio. You're listening to the Human Upgrade with Dave Asprey. Today we're going to talk about biohacking your body. But good God, I talk about biohacking all the time. What does it even mean? But we're gonna talk about doing it for Earth versus space. And I've got a guest here, a fellow biohacker named Alan Graves, who is CEO of Do Not Age. And the reason I wanted to have this conversation is that years ago I had a chance to talk with the president of SpaceX and I asked her, I said, well, you know, you've spent hundreds of millions of dollars hardening electronics for space. What have you done to harden astronauts for space? And she looked at me and she said, In 17 years no one's ever asked that question. And I'm like, oh, you know, you can't have engineers planning to send people to space because those are the same engineers who design airplane seats. And have you ever been comfortable in an airplane? I don't think so. So we've got to have someone who understands biology and someone who understands environmental engineering in order to be able to solve a lot of the problems, including designing buildings and things like. So today we're going to talk with Alan Graves about that unique question and we're going to talk about why he has a company called Do Not Age, which is a UK based longevity company that makes supplements a lot of which you've heard of probably. And we're just going to have fun talking about biohacking. So Alan, welcome to the show.

Thank you, Dave. It's a pleasure to be here.

So you're going to go into space with Virgin Galactic, huh?

That's correct, yes. I'm shooting off in I think the end of 2025.

The end of 2025. Did you have to do all kinds of crazy health tests in order to do that?

Not yet, but there are a lot of. It's quite a rigorous training program to be able to go up to space, but obviously they do it once you're quite close to already being, being flown up.

Are you old enough to remember one of the first first person shooter video games called Doom?

I do remember Doom. It's one of the first games I ever played.

Ah, me too. So the guy who created Doom was the first person to go to space privately. And I flew in a private jet with him like maybe eight, nine years ago. And he was telling me the story that during his medical evaluations to be Able to do this. They looked and said, oh, you have some weird genetic thing where one of the ducks in your liver is backwards and. Or something like that. And. And so you're not gonna be able to go to space. And he's like, I got you. And he goes, and he has this surgery, and he shows me this huge scar where they went in and like, reversed an organ so that it would match the standard template so he could go to space.

Wow.

Would you reverse an organ if you had to, to go to space?

Probably not. I try and avoid. I try and avoid surgery where possible.

I think that's a good call. I would leave my organs where they are. Unless they needed, you know, unless they needed some serious editing for longevity. Yeah, but still, it's. It's an interesting idea. Are you doing this because it's been a lifelong dream or is this like a publicity stunt for do not age?

Neither. So I think what I realized as I got older was, first of all, similarly to biohacking. You know, when I was brought up, I was taught aging was not malleable. And then, of course, I realized it was, and that's why I dived into it. It's the same thing with space travel. I didn't. I didn't believe. I didn't even think it would be possible for that to happen. And then once I realized it was, I started to look into it and see that the response that people have had that have been into space and how it changes their perspective on life and the amazing things they do for humanity after they come back down. And so I decided, I want a piece of that.

It. It's funny, I grew up in a family where flying to space was normal. One of my uncles was a tech entrepreneur, and he was named one of the top 10 most influential investors in private space travel 10 years before the X Prize. So our. Our family reunion conversations were about physics and how to go to space. And like, oh, y. It's just like, we're going to do it.

So what do you got?

Most of my family works at national labs on high energy lasers and stuff like that. So it was one of those things where. Of course. But I realized, I think I lived in science fiction. Not to mention the other part of the family was from Roswell, New Mexico, where all the aliens were. So it's like, we'll do this. And now that it's possible, I looked at sending a single coffee bean to the moon. So that bulletproof coffee back when I ran the company, I'm working on re establishing My control over it.

But.

What happened was I was going to send it up with a little bit of extra payload for someone else and get it sent there just to be the first coffee on the moon. And that was for marketing. I don't know. That's how humans expand is through chemistry, including coffee. That was my idea. But maybe just going, going to, going up with Virgin Galactic is the thing to do.

Tell me what you're going to do.

To protect yourself from all of the bad effects of EMFs and ionizing radiation and all the other things that happen when you go into space.

Well, I think ultimately it's about testing. So testing, getting your blood done before you go. I know that you're a big proponent of testing as well. I don't go quite as deep as Brian Johnson, but I do do a lot of testing to stay on top of things and things like nad level, Sato an activity, inflammation markers, things like that. And then obviously I'm going to be relying on the Do Not Age products to keep me healthy. And I think it will work. But if not, then I'll die on my sword, won't I?

So testing doesn't protect you from space? Testing just says whether space, you know, damaged your DNA and things like that. Yes, I mean, same thing. I test everything. I've spent 2 million bucks over the. Actually probably 2 and a half at this point over the last 10 or 20 years. I don't, I don't spend at the rate that Brian does. But those tests, you can, you can do them, but like you can predict what space is going to do to you because we have enough data. So, I mean, you do not age makes enough supplements. I'm assuming you're going to sneak cement onto the air or onto the rocket. How does that work in my luggage?

Well, I mean, this, the space travel is only for. It's only for a short period of time. So I don't need to take any supplements up with me. And in fact, I'm pretty sure I'm not allowed to as well. So you can't take anything up with you. Unfortunately, the spacesuit is designed very specifically. It's made to fit your body. You do get to keep it afterwards, so it's a nice memento. But I will be taking extra. So rather than taking more supplements, I'll be taking a higher dosage, if that makes sense.

Higher doses?

Yeah, things like the Cert 6 activator, our most popular ingredient. We've proven that it repairs DNA. And I think that kind of ingredient is going to be Very important for protecting against those things.

I was the, the last guy to interview Dr. Veach before he passed away. Y. Dr. Veach was one of the preeminent keto researchers and mitochondrial researchers who'd studied them for 40 years. In fact, he studied under Hans Krebs, who, you know, I would say invented, but at least documented the Krebs cycle, which is how mitochondria work. And he was saying in that interview that ketosis is necessary for space travel. If we have ketosis, it'll protect your DNA. And he was so convinced of it. So will you be keto nicota space?

I will not. I probably won't be changing my diet too much, to be honest. Yeah, like I said, I think I've got things pretty much dialed in and optimized now, maybe, except sleep. I still struggle with sleep sometimes. But, you know, nobody's perfect.

No one's perfect, that's for sure. All right then, what do you eat?

So I now have quite a heavy meat diet. That's what I'm doing at the moment. And I do feel better on it. In fact, I used to be fully vegan for around seven years.

Wow, you lasted a long time.

Yeah, yeah. My brothers were like, oh, you're just going through a phase. And then when I, they were, they were quite smug. When I stopped being vegan, I switched to pescatarian for a while and then obviously read up a lot of data on the, on the carnivore diet. And whilst I'm not actually on the full carnivore diet, that is the vast majority of what I eat now. I try and stick to high quality steaks and organ meats as well. I find there's a lot of benefit for organ meats. And like I say, for me, my test results are looking good and I feel a lot better. So I'll, I'll do it for as long as I still feel good.

It. It's really interesting how, how it's evolved. I was also a vegan and then a raw vegan and.

Oof, that must have been tough.

Oh yeah, it was tough. You know, I tried all these, all these different things and then you feel extra energy. But so many people who are, who are vegan end up with joint pain and they just wake up, they're always crunchy and sore. It certainly happened to me. And then I started getting autoimmune problems and all these other kind of unexplainable things, but it couldn't be the vegan diet. And then when I came out with bulletproof I'm like, okay, cyclical, intermittent fasting. And keto seems to work really, really well. And you can't eat all the veggies. A lot of these veggies are screwing you up. And then when the first carnivores came out, and I tried that a long time ago for three months and it actually screwed me up as well, but it was pure carnivore. What you realize is that there's not a lot of toxins in meat, but there are some things in plants, like the stuff you have in your Cert 6 product, things that you actually need from, from plants, and that not all plants are created equal. So my prediction was that they're going to end up going from oh, I only eat meat to I eat meat in low inflammation plants. And I'm like, boom, nailed it. That's what I do. I eat grass fed beef and butter just like you would read about in the bulletproof diet. And I eat a small selection of plants. But what I understand now, and I want to go deep with you on this, if it's an area that you're conversant in, is that there's a bunch of these anti nutrients, right? And some of the supplements that you make can, can help to overcome some of the anti nutrients from plants. And phytic acid is one that slowly sucks minerals. So if you go to space, lose bone density and if you eat, you know, tons of things full of phytic acid, like rice cakes and oats and all that, then magically you can get weaker bones over time. But oxalic acid, which is chapter one of the bulletproof diet, it's probably more nefarious than I believe 10 years ago. This is the thing in lacy, kale and spinach and almonds. And this is an important one, raspberries. So when you eat this stuff, it builds up tiny little crystals over time. And all of our bodies have a different tissue capacity for this. And when you hit capacity, like Liam Helmsworth on the vegan diet, after four years gets a kidney stone made of calcium oxalate and it's from the damp plants. And the plants don't want us to eat too many plants because they don't like it. So we build up over time. I hit it early because I was doing sprouted or soaked almonds with raspberries and kale and spinach and sweet potatoes and beets, which are all high oxalate foods because those are the superfoods. And that's why I keep making fun of kale, even though spinach is worse than kale. And so are raspberries. Even though I love raspberries, but I actually still recommended them back in the day. Now I don't eat raspberries, I just eat blueberries instead because they don't have this.

You don't eat raspberries at all? No, I do, but on a very rare occasion I do try and stick, I stick to things like blueberries. I like blackberries as well.

Yeah, blackberries are quite low. It's, it's profound that people in the anti aging movement even sometimes like, well, there's good stuff but they don't look at the bad stuff. And I'm like, well you should probably avoid the bad stuff or counteract the bad stuff with supplements because the bad stuff is unavoidable. Right?

Well, I think the way I tend to approach it is try and avoid anything that has large amounts of bad stuff in if possible. And then if I'm then missing out on the good stuff, use supplementation to give me that good stuff. And so for example, SIRT 6 activator is derived from seaweed. And so it is just the bit that you need rather than any of the other bits that may cause buildup.

Makes a lot of sense to me. So you switched over to grass fed steak, I'm assuming. Do you eat chicken?

Again, it's same as raspberries. Every now and then I will, I try not to be too much of a stickler for it. But no, it's not in my, it's not in my core diet. I don't really believe that it's particularly healthy.

Okay. So we're very, very aligned on that. And I always put chicken down there below pork on my preferences. And I don't think pescatarian works because there's not enough protein in fish, at least most fish. And if you get that much protein, you're going to be getting a lot of toxins from. So I'll eat fish, but I wouldn't want to live on it.

Yeah, same here. I really enjoyed the taste of fish as well. So that was one that I had sort of overcome and that was my stepping stone between the veganism and what I do now was I was pescatarian for a little while.

What was driving that? I'm really curious. So I mean we're both biohackers but like which of the arguments for that made sense to you?

So I was speaking with, obviously it's unfortunate I have to speak to a lot of the top researchers and scientists in the space. I think it was mentioned on David Sinclair's podcast as well about the metadata showing the most long lived diets. And I think they had veganism quite high on there, but they also had, above that they had a pescetarian. And so that was one of my decisions. And I think I just knew at the time that the veganism wasn't, I wasn't optimal when I was doing it. And so I needed to make a change. And maybe the change going straight to beef would have been a little bit, a little bit too much of a jump for me. So I eased myself in.

Good, good work. It's funny, there's no data ever showing that the vegan diet makes you live longer because there's never been a vegan society for more than a generation. Right?

That's true.

There are vegetarians, but vegan is very, very rare because the more plants you eat, the more calcium you need to try and balance out all of the anti nutrients. And you can only get that calcium in those doses from dairy or maybe in Japan from fish bones. There's, there's some, some things you can do with small fish that help, but it's, it's pretty weird. So let's talk about your transition to becoming a biohacker.

Okay.

When did that happen?

So it would be probably around 2019 when I really started taking it seriously.

Okay.

And again, it's, that's the start of 2019 was when I realized it was even possible, because again, before that I wasn't even in my realm of possibility because I was taught all my life how you can't do anything about how you age. You can't do anything about your health, you can't do anything about how long you live. It is what it is. Everybody ages. There's nothing you can do. And so I never even thought about it. And then I started to hear things and read articles and watch podcasts. And I remember teaching myself to read a scientific paper after listening to a few podcasts, because they said, oh, all the data's here. These things can help extend lifespan and reverse these diseases. And I thought, well, I want to check it out, I want to see the data. And so I went and tried to read the scientific paper. And they use all these big words and I didn't know what half of them meant. So I had like two tabs open. I had the scientific paper and then like Google definition and I rewrote the papers in simple English so that I could understand it and taught myself basically how to read scientific papers from there and then realized what they were saying. Was true. And also then that has become a staple for do not age. Because that's what we do is we translate the scientific papers and make it easier for people to digest. And so that from what I did for myself in the beginning, back four and a bit years ago, is now still kind of very. In the DNA of dune age, if you will.

It's really funny. It's hard to read a scientific paper because the language of academia is one that obscures truth. They choose a passive voice, complex sentences. They use big words and they use small words. I think because it makes them feel better.

I think so.

You know, I don't understand why it should be hard to read those things. So same thing here. I started reading them in my. Probably my mid-20s, and I'm a computer science guy. So I'm scientific, I know how to do science. But the vocabulary was completely baffling. But what I would encourage people to do, if you're just saying this is too much. No, just keep reading the papers. And after you've read 30 or 40 of them, all of a sudden, just like learning to read English or something, it becomes clear and you're like, oh, now I can follow it. So it's just teaching yourself a new lens. You had the same experience. I see you nodding, right?

Exactly the same. That's what I did. Now I can do it, you know, obviously, without having to have two tabs open. But originally it was very difficult. Obviously, the alternative for people is to look at the Do Not Age emails, because we do it for you, but for me, I just wanted to. I wanted to really understand it. And so I did it all myself. And like you say, once you've done it 30 to 40 times, which sounds a lot to some people, but it's really not that. It's really not that much. Then you get used to it and you can kind of do it relatively quickly.

Yeah, you can skim through one and it feels like a superpower when you first get to do it. And every now and then I run across something where it just gets so deep into either equations or into just esoteric cell pathways that. And this isn't one of the 30 or 40 that I paid attention to. And then I have to slow down and double check, like, why is that?

That.

But I just want anyone listening, I want you to know you can do this too. There's no monopoly on that. You can read the do not Age emails where they translate them. I've got 3,000 blog posts where I talk about these things. And now there are AI tools for researchers that will summarize a scientific paper for you. I don't remember the name of it. I don't have too many AI apps on my phone right now. But if you come across something and you feel like you can't understand it, you can ask an AI thing to translate it for you at whatever level of understanding you have, and it will do that. So the question is, who paid for the paper? Because it's almost like big pharmacy might have maybe done a few bad things. And even you mentioned David Sinclair earlier. It looks like some of the original. I think it was resveratrol research maybe wasn't like someone faked something back in the day. Did you hear about that?

I did. I think that's disputed. And it was a particular molecule, srt something, something they were looking at. Eventually gsk, as far as I know, did close down the company. But again, I don't, I think what David Sinclair's done for the industry is very commendable and I think absolutely.

He's been on the show. He's, he's a friend. And I don't know that that was his research specifically. I think it was like someone in his lab, if I, if I remember that. But there, there was some controversy over it. The other thing is one of the biggest things that big pharma companies do, and I've seen this over the last 20 years over and over, there's a promising new treatment. Whether it's a device or a drug, they will buy it to kill it because it works better than what's on the market. And let's face it, if you have something that cures something, well, then the market goes away and it's just bad for business. So this has been something they've done over and over. So if you want to figure out how to live a long time, look at what the drug companies buy and shut down, because that's where the gold is.

Well, exactly. And this is why I am very happy that we have the protection on cert 6 activator because I'm already financially free, so there's. Nobody's going to be able to buy it off me. You know, we have the contracts in place with the Gorbanova lab, which are that there are in house researchers and everybody's doing it for the right reasons. And so we're, we're very happy that we can't be bought out. And of course, as I'm sure you can guess, people have already tried and we won't do it, which they don't like, so I'm sure they'll come after us some other way.

Oh yeah. Venture capital is a double edged sword. I'm grateful that I raised a bunch of money because it allowed me to fund the creation of the biohacking movement. But from a personal perspective, I'm working now on reacquiring all of the necessary controls in bulletproof so that I can get it to do what I want it to do. But I, I truly think there wouldn't be biohacking if I hadn't worked with external funding on it. But it, it's a double edged sword. I, I recommend entrepreneurs when I coach them all the time. You know, guys, let's, let's avoid funding specifically from professional investors. Get your money from true believers family offices. There's plenty of DECA millionaires and billionaires who want to live forever. And actually they could donate the money or they could invest in a startup that might work. And the pleasure that a wealthy, wealthy person gets from helping someone become possibly wealthy and helping someone solve a societal problem, it actually feels better than just giving the money away. And I think there's room for both. I donated the first $50,000 to the Xprize foundation that became Elon Musk's $100 million carbon capture X prize. It's like it's okay to donate, but even that is a competitive thing. And I've donated a bunch to wells in Africa and schools for girls and things like that, mostly to support people who I think are doing amazing work in the world. The water charity, the women's Alzheimer's project. But if I can invest in a company where someone has fire and they're ready to go solve this big problem, it feels better. So this is a message for everyone listening. You can go to professional investors for money, but their job is to slowly, slowly peel away your rights and to put controls in place versus people who are true believers in your mission and your cause. And I'm fortunate that many of those people also invested with me.

So I think, I think time horizon is a big thing as well. Like, you know, a lot of people think, right, how can I, how can I make a company that makes money, loads of money straight away? Look at a longer time horizon and you will win in the long run. You know, would do not age. Could be super profitable if we didn't do all this research and put millions into research every year. But we're looking at the, we're looking at it long term now. We're doing it for people's health. But ultimately Even if you were looking at it from a business perspective, it's still a smart move because we're going to be in a great position in 100 years time. Whereas, you know, like a typical supplement seller, 99% of them aren't going to be around.

So it's true. There's a lot of pressure on the supplement industry and in some countries like Canada, they just basically shut down the supplement industry with recent regulations. I've always, I mean I've lived in Canada straight for 12 years and I live in Canada and Austin and it's almost impossible to buy quality supplements up there. It's getting harder and harder and they're making it almost as expensive as buying pharmaceutical drugs and it's drug companies doing that. Are you worried that you'll just get regulated to only being available for pets or something?

No, I'm not concerned. We've already overcame, we've got to the size, we've got to largest NMN supplier in the world. Cert 6 activate is obviously a huge deal. We have Sulfora Boost as well. We've got there within four years of the company being around. So obviously there's been a ton of hurdles in that time. So any hurdle that any kind of regulator or anybody throws at us, we will overcome it. And again, it helps to be in it for the right reasons because it's not a matter of oh, should we do this, do we need to do this? We're doing this, how do we do it? I just see it as problem solving, just like every entrepreneur needs to.

That's what hackers do. If you can't just do it the normal way, you go around underneath or do something disruptive. You started with three products that do not age. You had nmn, Resveratrol and Berberine. And now you've got a bunch of longevity products. What's going on with NMN in the US because it's become very, very difficult to get. Can you walk me through what's going on?

I could do my best. The FDA aren't very talkative, really.

The fda, they're such good people.

No comment, your honor. So what's essentially happened is towards the end of last year, which is 2022, they announced that NMN couldn't be sold as a dietary supplement in the USA. Then it turned out to be just like NAC a couple of years before it where they had said that once, but then after that everybody could still provide NMN and it was, it was no issue. We certainly didn't see an issue for it because the case of whether something's a supplement or a drug is usually if it's already been marketed as a dietary supplement for a long time, then you can't then just come along and say, actually I'm going to make that a drug. But it seems like that's what they're doing and the FDA seems to be on their side. And so I think the less I say about that, the better. I don't want to.

Yeah, maybe because you're in the. You're actually selling the product directly.

Yeah. But I also think that whatever happens, do not age will always make sure that there's a high quality NAD booster available for everybody all over the world.

For listeners who are new to the show or new to biohacking, NAD is very important anti aging molecule. I've written about it in multiple books and it makes your mitochondria work better. You can do it intravenously and it declines as you age. And NMN is a potent way to raise nad. When the first research came out showing it worked better than nicotinamine riboside, I bought a kilo of it from China for $3,000 because you couldn't buy it in the US at any prices. Mid 20, 20, 15ish, I would guess, and had it tested and took it and it was probably wasn't worth the trouble compared to NR because encapsulating your own $3,000 bag of white, whitish yellow powder that was suspicious to get into Canada and keeping it in the freezer, it was, you know, a little bit extreme. So I went through all that and I've taken NR and NMN and niacinamide, all the things that work and I think it's an important part of anti aging. But why did you go with NMN specifically?

So NMN specifically at the time was because I spoke to a lot of the researchers in the industry. So when dude age first started, I don't have a scientific background so I needed people around me that did. And so I managed to network with a lot of those people. Now we have, like I said, Professor Gorbanova was our lead researcher. There's lots of other people that I won't mention, but they're very well known names that have also been involved with helping us. And the overriding belief was that NMN was superior. We now provide both. So people can choose whether they want NMN or NR. Both are provided by Do Not Age.org but I personally, well, I actually personally take whatever the hell the office sends me, but I don't know which one is superior because they have very similar results on NAD level, which is, I believe, the most important thing. And that's what we test them for.

Impurity is really important. Have you found metals or other impurities in NMN or NR when you purchase it from overseas?

We used to. I mean, there's heavy metals in everything in sort of trace amounts. So that. And that will always be the case. But there used to be some pretty bad batches. We also found we had to kiss a lot of frogs before we found really good suppliers of these four ingredients. We now partner with a company called Ethyl Farm and they make a fantastic NMN raw ingredient. And they've never let us down. I think we're over two years with them now. So obviously every batch is still tested. Do not age any men is also the only one. That's where the purity is guaranteed to your door as well. So we guarantee it to your door wherever you live in the world. Because part of our mission of extending healthy lifespan for as many people as possible for as many people as possible is also important. So we need to make sure that everybody around the world is covered.

It's a lot of work to get it, especially around the world. I've had so many packages destroyed when I've been sending supplements, especially to Europe or Central or South America.

Yeah.

And when I say destroyed, like I'm calling out Germany, for instance. The number of times German border people, they see a bottle of supplements that should be legal in Germany that a German ordered with their own money, and then they incinerate them.

Yeah.

Which contributes to global warming, by the way. I just wanted to call that out. You bad, bad German border people.

And they're not the only ones as well. There's lots of other countries, some are.

Much stricter, but Australia is another one. Even Canada. I mean, I've had my own supplements sent to me for filming. And they arrived slashed open so they could look inside. And you're like, guys, I was going to film that. And it's got a big blue sticker on it. So if you're out there and you're saying, well, why won't X company send me things? Or why is it so expensive? It's because you've allowed your government to do that and you should make them stop, just straight up, like, they are not allowed to do that. You didn't give them that right. They just took it and they're using it against you to keep you sick or to restrict your ability to take care of yourself. It's okay. For politicians to get old, it's just not okay for you to get old.

See the difference? Yeah. And I think one of the ways we've got around that is as we've grown, we've built facilities in various different places. So we have the usa, we have the uk we now have Europe as well, mainland Europe within the eu and then the next one is Australia. And then after that it's going to be the Middle East. And so the more localized we can make it, the better.

So your three products were nmn, they were resveratrol and let's talk about resveratrol. And then the other one was berberine. But with resveratrol, what form do you use? Where does it come from and why is it important?

So we use trans resveratrol. It's the best form to use it. We actually use synthetic. So again, when we first started, we didn't. We wanted to use a natural extract. We thought that would be superior. And then thankfully, now we have ways to test these things. And ultimately the natural extracts, you can't get as pure and therefore they don't quite work as well. And also one of the other things we found is in the supplement industry, a lot of transverse veritrol will be shown as part of a blend or a red wine extract or something like that, which means then the powder becomes a brown or a dark red color. And there are a lot of bad players that can then hide low quality ingredients in that. That doesn't mean everybody, but some of them do. And so it's one of the things we want to stay away from. Another thing we were very naive about at the beginning was we actually combined the NMN and resveratrol into one capsule, which, you know, we don't do any longer because of what we know now. NMN is taking empty stomach first thing in the morning. Resveratrol's taken with some kind of source of fat, usually with the first meal of the day. And resveratrol activates sirtuin 1. I can talk a little bit about sirtuins if you want.

Sure, let's do it.

Yeah. So essentially, longevity proteins, for anybody that's listening, they go around and do the repair work. In your body, aging really is just an accumulation of damage, and then that damage needs to be repaired. When you're young, your sirtuins, they go around the body doing the repair work very quickly, very efficiently. And as you age, your s slow down, you have less of it. And these longevity genes need reactivating. And so resveratrol activates Sirtuin of 1. And there are seven of them aptly named Sirtuin 1, Sirtuin 2s, etc. And Sirtuin 6 is the most important one. And that's why we have SIRT 6 activator. And Sirtuin 1 is the second most important one, which is what we use resveratrol for to activate it.

Why do you use resveratrol instead of pterostilbene?

So pterostilbene just doesn't have enough proof behind it. The only papers I've seen that have recommended terastylvine over resveratrol are ones that where the resveratrol. So resveratrol is very poorly absorbed when you don't use fat with it. If you just drink it with water. And I mean very poorly absorbed, like 5 to 10%, which is extremely low. So those papers show terracetelbine is having a bigger effect than resveratrol, maybe because it's more easily absorbed. But we believe resveratrol is actually a better activator of so term one when it's taken correctly with the source of fat.

So you might do something weird like take danger coffee, put in some butter and some mct, blend it right up and, and magically all of your fat solubles like vitamin D would absorb even better. Who would have thought, right?

Yeah, exactly.

So that was why you went with resveratrol. And I agree with you, if you can get, if you properly identify the actives, you can get a synthetic that works really well as long as you're paying attention to things like isomers. Are you getting bioidentical molecules? Are you getting half mirror image molecules? Did you solve that problem?

Yes, we did. Well, I say we did. We paid somebody to solve that problem. So that's how most of us solve problems.

Right.

It's the same as when I say we do research. I'm not in the laboratory, I don't do the research. Our scientists do the research.

Yeah, you're just one guy. So you do some of it, but you're aware of it.

Yeah.

All right, so you solved that problem. And there's another thing that happens, especially in the world of pharma where there's an assumption that one thing is the important thing and there's no actual data or proof that it's not three things in the right ratios. So they'll tend to throw away a lot of things that are part of the solution in the eternal quest to find the one active ingredient. Yeah, like I think we should just assume there's always 6.7 active ingredients. And then like our whole world would look very different because we would start filtering for complex effects. And this is why biohacking and systems biology is different than big pharma. And even a lot of western diagnostic medicine is like, well, there has to be a cause. Like, well, was it diabetes or lack of sleep?

Oh my God.

They go together. Right? So like that's why biohacking is like creeping in. We're sort of surrounding and soaking into the world of medicine. And there's so many doctors who listen to the show because it helps them to think about it differently so they can help their patients better.

Yeah.

So I'm, I'm always inspired when I see doctors working on longevity and aging and performance instead of, you know, how to set broken bones.

We need both, definitely. And we do help a lot of them. Again, we don't, you know, we don't reveal their names and things like that because they obviously, they don't want to get struck off. But ultimately there are a lot of doctors that reach out to us and say, look, I understand that what I'm being taught isn't quite, you know, it's funded by the wrong people, shall we say? And so can you help me with this kind of functional medicine? And we do help them. And so they're, there's hundreds of them at the moment that we're helping and hopefully we can change that to tens of thousands.

Let's talk about one of my favorite anti aging products that I've been taking for five years now. I've given talks on it at higher end anti aging conferences and it's one that I see that you guys sell calcium akg. Yeah, this is something that honestly, after you get through your basic stack stuff, something that should be high on an anti aging list of supplements. Why do you make it? What does it do?

So calcium AKG is the calcium salt form of akg. And essentially it just that the calcium salt just makes it uptake a little bit easier into the system. Obviously, boosting AKG is what it's all about. You mentioned the Krebs cycle earlier today. Very important in the Krebs cycle, so for energy, but it's also important for things like bone density, saving of frailty. The mouse trials there were the fur was the gray fur turned back to dark fur again. So it wasn't just staving off grays, it was actually reversing grays, which I think is pretty cool. And you know, we're yet to See if that works in humans as well. But and the biological age, which again the test that was used is questionable, but at the biological age seemed to show an eight year reversal in a very short period of time, which is a very positive.

There's a lot of interesting biochemistry around it, but it's alpha ketoglutarate and I, I definitely take a couple of those every night.

Yeah.

And I think it's, it's advisable. But then again I am at about 84 pills in the morning last time I counted and something like 40, 45 at night. So I don't mind a couple extras. But if I could get it down to only 80 per day and know which ones were going to matter, which ones weren't, I'd be happy to do it and it would save me some money.

Yeah.

So I'm not suggesting that most listeners would swallow that many pills or would want to swallow that many pills or need to. It's just that when you realize this one does this, this one does this if it's within the set of your goals, which you and I both have the let's live unreasonably long and let's say as young as we know how to do, some people will go out and spend money on expensive wine or they'll go on vacations or they'll do whatever and biohackers I'm going to spend. For me when I was Younger it was 20% of my income was on health and longevity and wellness, partly because I didn't make that much and partly because my brain didn't work if I didn't do it because I was pretty sick. So fortunately you and I are both at a different place in our lives and so we can do that. And I'm encouraging listeners to consider that it's not about, well, I can't do that right now, so I'm not going to do anything. You start with the lowest hanging fruit that are most affordable. Right. And then you work up over time and if you just do a little bit in your early 20s and your mid-20s, the benefits from that are so long because you get compounded interest.

Exactly.

Like if you put a hundred bucks in the bank if they were still paying interest these days, then over time it becomes a big number. You put just a little bit of care into your biology and anti aging and well, okay, now you have 80 or 90 or 100 years of those benefits stacking up. So I wish I would have known what to do better in my early 20s because I was trying There just wasn't good data today. You have amazing data. And you can say, all right, maybe I'll start with resveratrol. Maybe I'll start with one of these other compounds and maybe you'll match them with where your problems are. You can't sleep, do that. Stress, do that.

Yeah.

And you guys have a bunch of cool stuff to do that.

Yeah, no, I completely agree. And some of the. There are some really entry level products that aren't expensive at all. You've got your omega threes, creatine, collagen. There's all these things that you can take now that are extremely low cost. If people are. If that's what's putting people off. The one thing I would say is prevention is so much easier than cure. So don't think because you don't have huge issues now that you're not aging every day. And like I say, if you prevent it, it will actually end up costing you a hell of a lot less in the long run than if you're trying to cure it down the line.

Oh, yeah. Prevention is so much more important. It's one of the reasons that I. I used to run an anti aging longevity nonprofit group outside of Stanford University in Palo Alto. And I was maybe 25, 26 when I joined, and I was the only guy under 60 in the whole place. And about 100 people would meet every month and we'd interview the leaders in the field back when you weren't really supposed to be doing longevity research because it was impossible.

Yeah.

And finally they asked me to be president and chairman of the group because I was so excited about it. And I was just learning from these old guys and older women who were just reversing their age, and they had so much more energy than I did. I'm like, I just need some of that energy. And that was what showed me it was possible. And one of the, one of the more inspiring things was my friend Mike was 88 at the time, and he'd call me at 11:30 at night, just all excited about this stuff. And like, we got to work on this, and I'm kind of getting tired. And he just really had more energy than me. And he ended up falling in love with a much, much younger woman. And people say, oh, you know, that's stereotypical. You know, it was one of the things where he had the energy and like, the youthfulness in his mind and his body and his energy that it was a good match.

Right.

And few people can pull that off. And he'd been doing it for, you know, 50 years.

Amazing.

Yeah. Like what you're going to look like or I'm going to look like. As we age, because of this investment, it assuming things go according to plan, we have a much higher chance of this, right?

Oh, yeah, definitely.