Blood Sugar Hack: The FASTEST Way to Burn Fat, Optimize Hormones & Reverse Disease | Dr. Ben Bikman

70% of all calories consumed globally come from starches and sugars. And so the average individual, because they've been told, is eating five or six times a day. It's all carbohydrate heavy.

My biggest critics online are the dietetics. And I'm just like, guys, you've done a shitty job. Look at the health of the country and look at people who eat hospital food.

Stop talking to the average person who wants to lose weight. The traditional view is cut your calories. But if you're not addressing your insulin, that's just going to promote hunger. Hunger always wins. Before you know it, you'll be right back where you were. Without insulin, you die.

I've read studies saying that low insulin is four times more deadly than high insulin. If you do some research about insulin and Alzheimer's, you'd want to be on a low carb diet. But you might want a little squirt of insulin every now and then in your brain, because it seems to help. What concerns me is if you take a little bit of insulin and you put it in a nasal spray and you spray it up your nose. It's a way of treating Alzheimer's. So why is it when I raise insulin, my brain works better? You're listening to the Human Upgrade with Dave Asprey. Today we are going to have an amazing conversation with Dr. Benjamin Beekman or Ben Beakman, who is an absolute boss when it comes to bioenergetics, metabolism, and the way the body actually works. And as you might know, I kind of have a mitochondrial fetish I developed in the late 90s because I had chronic fatigue syndrome and fibromyalgia and brain fog and like 300 pounds of weight. And I learned from people in their 70s and 80s who are running a longevity non profit group. And soon they asked me to run it. And I'm the only guy under 50. So mitochondria have been at the very center of biohacking. It's like you change the environment around you so you have control of your biology because your mitochondria listen to the environment. So now we have Dr. Beekman here to talk about what's really going on in there. He's a fantastic teacher, that very, very learned human being. And I'm excited to share his wisdom with you today. Ben, welcome to the show.

Hey, Dave, thanks so much. It's nice to be with you again. This is great.

This is our second or third interview.

I think it's our third.

I think it's our third. I think your YouTube channel, the stuff I've seen from you lately on Instagram is so good. You're one of the few people in academia who's just willing to say, well, here's what the evidence says, even though it's not popular. And I just. You so appreciate that. Do you take a lot of hits? Like, do you have colleagues like, no cholesterol is bad, and then they're like, not have lunch with you and eat vegan crap and all that?

Yeah, yeah. Well, that's a funny little kind of side comment, but yeah, I mean, one of the most sobering moments of my career came as a pre tenured professor when I had a bunch of other professors try to get me fired from the dietetics department. Actually, in particular, I was deemed a heretic of sufficient vileness that they tried to get me removed. So, yeah, it's. There have been some naysayers, no doubt. Yeah.

Well, thank you for finding the good fight. And if I can just say there are a very few number of functional dietitians. All of the other dietetics or dietitians, they are the McNuggets in hospitals people, they are the school lunch people, and they are so brainwashed or maybe just downright evil, I'm not sure. But they're the ones saying put, you know, corn syrup and canola oil in baby formula and it's, it's just not how you do it. By the way, I'm not saying that that is an all baby formula, but certainly around the world it is. And just my biggest critics online are like, the dietetics, the dietitians people. And I'm just like, guys, you've done a shitty job. Look at the health of the country and look at people who eat hospital food. Stop talking. And I just move on. Do you do the same thing or are you more polite?

Well, no, I think, I mean, I definitely have to be a little diplomatic, depending on who I'm talking with. But I agree generally that while there are certainly dietitians and these licensed individuals who challenged the prevailing thought, it is probably the most dogmatic field I've ever encountered. And if you deem yourself worthy to step into that territory, you need to be ready for the fiery darts, because they come after you.

Well, they're very well funded by Big Pharma and Big Ag. So there, there's that you've been, I'd say, an outspoken voice on insulin resistance and how it relates to disease, and you're doing it both in a public sphere with your YouTube and you're doing it in your book, you know how to not get Sick. So talk about insulin resistance. What is it and where does it come from?

Yeah, insulin resistance is best defined as a pathology with two parts. So it's a two sided coin. One side of the coin is the obvious side, and many people don't appreciate that there's another. But that obvious side of the coin is the fact that the hormone insulin isn't working particularly well at certain places of the body. That is the insulin resistance part, that some cells of the body, not all some cells, have become resistant to insulin's effects. Now, all of this is compounded by the other side of the coin, which most people do not appreciate. But if you are invoking the term insulin resistance, you're invoking two parts, the one I just described, but then the other, which most people overlook, which is hyperinsulinemia or high blood insulin, there is no separating the two, that it does not matter. If insulin resistance exists in the organism, insulin levels are higher. The two ideas, they are inseparable. So that is insulin resistance. And of course, the relevance of it is just the fact that it contributes to. Well, not only because it's so common worldwide, it's the most common health disorder, but it's so connected and even in a causal way to virtually every chronic disease. All of these, what I like to call plagues of prosperity, while they do have individual noxious stimuli that can cause them, they have a common one as well. And so the drum that I try to beat so loudly is that there is a common origin to so many of these problems, and it's insulin resistance. So rather than chasing these into putting all of our efforts into chasing individual stimuli, let's really put most of the effort into addressing the most common thread that if we can pull that one out, everything else just starts to crumble.

The number one cause of insulin resistance is.

Yeah, number one cause. So more and more, Dave, as I've thought about insulin resistance, which I do a lot, I've come to the conclusion that there are two paths to insulin resistance. There's the fast insulin resistance and then there's slow insulin resistance. And that's a bigger conversation that I don't know that we want to get into yet. But briefly, slow insulin resistance is the result of fat cells that have undergone significant hypertrophy. So that's the conn of how fat tissue explains insulin resistance. Now, don't assume that everyone listening, that that just means only as we get really fat and obese, depending on the ethnicity, it can be Only a little bit of fat gain, and it's already resulting in larger fat cells that are causing insulin resistance. So that's an insulin resistance that settles in a little more slowly and it reverses a little more slowly. Fast insulin resistance, which is the one to I think most explicitly answer your question, is a result of stimuli that can literally trigger insulin resistance within hours, but then they can be resolved within hours to days or maybe a week or so. And in that case, the one that I believe is the. Of all of these, what is the most relevant cause of insulin resistance? It is in that fast lane. The most relevant is too much insulin. And so just to really bring this full circle, because it does kind of create a bit of a circle, I posit that as a person is eating chronic constant carbohydrate consumption, which is the global diet, 70% of all calories consumed globally come from starches and sugars. And so the average individual, because they've been told, is eating five or six times a day. It's all carbohydrate heavy. The average individual spending every single waking moment in a state of elevated insulin, never giving the body enough time for the insulin to come down. As insulin wants to start to come down, they've bumped it back up again. And so it's that chronic insulin that starts to make the body somewhat deaf to the insulin. And that's. And then it starts to feed the cycle where too much insulin is causing insulin resistance, which is in turn creating more. A need for more insulin, which is creating more insulin resistance.

I've read studies saying that low insulin is four times more deadly than high insulin. Is that true?

That's, that's remarkable. I could not believe that to be true and would only believe it in the context of type 1 diabetes. That might be why, if the population is a type 1 diabetic population, then I would believe that because it would suggest the person is underdosing to the point of lethality. But in a non type 1 diabetic, I would absolutely not believe those outcomes. But that's an important point, Dave, because a lot of the confusion that people have with regards to even the insulinogenic effect of macronutrients, like they will say fat causes an insulin release. And yet every single study that has ever shown that was based on a type 1 diabetic population, where because of their chronic hyperglucagon levels, there is this sort of unexpected quirk of eating fat in a person with type 1 diabetes. But in a non diabetic population, there's zero studies to show that fat has an effect on insulin? None. And so even in my own lab, a data, data we just have generated, we're about to publish, I can state it authoritatively, Dietary fat has no effect on insulin. And there's been a study that has ever shown it.

Thank you for saying that. When I write about fasting and intermittent fasting, I've consistently said if you have some butter and MCT oil in coffee or something like that, it has no effect on insulin or MTOR. And a third party actually went out and tested 300 different breakfast options to see their effect on blood sugar and on insulin.

And.

And coffee with butter and MCT was at the very top of the list. Is having no effect whatsoever. That's why you can do it during a fast. True or false?

Oh, Dave. Yes. You and I are completely aligned, in fact, to the point that I have, I've actually wanted to try, and with your audience, you're going to make it happen. I actually think there should be some nuance within the conversation of fasting that I have more and more. I consider there to be two types of fasts. One, which is a kind of true classic fast where you're not eating or drinking any calories that I call a caloric fast. And then what you and I are just describing is what I call a metabolic fast.

There you go.

Which is what. What determines whether the body's in, like, at the level of the cell, all of the biochemistry, like, the most famous effect being autophagy. Who determines whether autophagy is turned on or off? Well, it's actually insulin for the most part. And this is why famous fasting slash starvation physiologists like Dr. George Cahill, who is a legend to me, he described insulin as the hormone of the fed state. And in his estimation, which we ought to take seriously, he said, that's insulin. That really determines whether the body's in a fed state, high insulin or a fasted state, low insulin. Well, what if you're eating in such a quirky way that you are putting calories in, but you're keeping insulin low? So ketogenesis is uninterrupted, MTOR is not turned on, and there's no ceasing or inhibition of autophagy as far as the cells are concerned, you're still fasting. That's a pretty metabolically relevant scenario where I believe more and more, as much as there are people who say we need to be doing protein fasts where you're just eating protein during the fast, I actually think there's More value in doing fat fasts, to be honest. Now, there's no studies that have compared those two, so I don't mind if people disagree with. But for all the reasons you and I have just outlined, I actually think a fat fast is superior in its outcomes than any other form of fasting.

Having tested them all on myself and had hundreds of thousands of followers over the last 10 years, I. I find the same results and people get really mad. Like, well, the. In the mice studies, it was just water. It's because they didn't test the fat thing. And then I funded some research at the University of Washington around exclusion zone water and cells and how certain types of lipids, like C8MCT make mitochondria work better by changing what, like, very esoteric stuff. That's Dr. Gerard Pollock's work, and maybe that's why. But what I do know is the two types of fasting you're talking about, like a caloric fast or a metabolic fast. I, I characterize them as. There's a spiritual fast where you're okay to be maybe at a lower level performance, and you're. You're going to push yourself and be introspective. And then there's a working fast where it's the middle of the week. I have a job and kids and stuff to do. So a little bit of fat makes fast completely painless, and you get the metabolic benefits. Because I couldn't do what I do if I was never, you know, if I was always just fasting on water, I think it would be miserable.

Yeah. Yeah. In fact, because you just invoke spirituality, I will just add a hearty amen. I completely agree with everything you just said.

I always look for alignment and areas where we maybe see things differently. Because, look, I have a perspective. I could be wrong and, you know, a lot. So let's find the areas where. Okay, that makes sense. And then the areas where maybe I'm full of crap. What concerns me is if you take a little bit of insulin and you put it in a nasal spray and you spray it up your nose. It's a way of treating Alzheimer's. It's also a really potent cognitive enhancer. So why is it when I raise insulin, my brain works better?

Yeah. Yeah. So I have to speculate a little bit, Dave, just because I want to. And I want everyone listening to know if whenever, whenever I mention I'm speculating, it's because I. I don't know of a specific study that I can rely on to answer. So what I Suspect is happening is that with the intranasal administration, you're able to get that insulin absorbed directly through that upper kind of wall of that nasal cavity. So this is. Insulin is not getting systemic.

Right.

In other words, it's not getting into general circulation. You are just kind of shooting it right up to the brain, especially the hypothalamus, which is, you know, right in that lower part or just above that nasal cavity. And it could be, now I'm theorizing, it could be that as the insulin profuses directly up through that layer, the epithelium of the nasal cavity and up, it just directly opens the doors and allows a rush of glucose to come in. It would be my speculation. Now, it wouldn't be contributing to the elevated insulin induced insulin resistance again, because if I had you on a table and I was measuring your blood insulin levels systemically, like from a, your arm vein, we wouldn't get any. It would be no, no change. There's no change in insulin at the level of the entire body. There's no systemic alteration. This was such a modest and such a direct administration. I suspect it's just moving right up into the hypothalamus, opening the doors. Because some of the brain's glucose uptake is dependent on GLUT4, which is an insulin itself, an insulin dependent glucose transporter. Whereas other parts of the brain, including in the hypothalamus, it has other, other doors, other glucose transporters that are just always open. The moment glucose goes up in the blood, it will flow into that cell, whatever the cell may be, the kidney or the liver. But then parts of the body, including the hypothalamus, will have some of these insulin dependent doorways where insulin has to come and knock. Now the door opens and glucose comes in. So it could just be that you are just bypassing any systemic circulation and going right to the brain, saying, hey, brain, I want you to open those doors and really pull in a bunch of glucose.

That makes good sense to me. And I've always been a fan of having exogenous ketones present and doing a little bit of nasal insulin. So I'm like, all right, neurons, you've got your ketones. Glial cells, you've got your glucose. Let's go. And that is a pretty darn good state of high performance. I just don't know how often it would be safe to do it, which is why I don't do it very often.

Yeah, I don't either. I would. Because too much insulin will cause insulin resistance. I Do think that'd be one reason, I'd say to use it judiciously, like.

Once a week, kind of.

Yeah, yeah. Oh, yeah, that'd be, I think, perfectly fine. But then second, there would be. There's another part of me that just thinks, well, is, is that, is that epithelium, that layer of the nasal cavity? It's not natural for it to see insulin. Would there be some long term effect? Am I stimulating too much growth? Am I going to make the epithelium start to get a little thicker? This is of course entirely speculative.

Oh yeah.

But if it's like on the order of once a week, like you're saying, that would have, that's such a modest bolus, such a modest frequency, that that wouldn't have any of these effects. I'm confident.

This is so fascinating and I know we're getting a little bit nerdy on things and at the same time, there are a lot of people who are 50s, 60s, 70s, they're getting early onset brain stuff. And if you do some research about insulin and Alzheimer's, you'd want to be on a low carb diet, but you might want a little squirt of insulin every now and then in your brain because it seems to help. And all the metabolic stuff that you talk about and I talk about, if someone's listening to the show today and they're saying, well, how do I know if I have insulin resistance? How can you tell with lab tests and how can you tell with symptoms?

Yeah, yeah, let's start with symptoms. Just because that's going to be something people can rely on a little more. Well, immediately with regards to symptoms. If you have just been told you have high blood pressure, insulin resistance is the most common cause of what's just called idiopathic or just run of the mill insulin resistance of run of the mill hypertension. So if you have hypertension, that's definitely a knock in favor, a check in favor of you having insulin resistance. High blood pressure, most common manifestation, if you have a family member with type 2 diabetes, you're on that spectrum as well. Very likely you're much more likely to have insulin resistance. And maybe the final one of the symptoms, before mentioning some clinical tests is, is the skin itself, where there are two distinct skin manifestations that are a direct result of insulin resistance. One is called acanthosis nigricans. Then the other one is skin tags. Skin tags is a little more obvious where it's just like a teeny little like mushroom stalk. Like it's not a Big rounded mole. It's a teeny little bump. People are probably thinking of it correctly right now. You can imagine there's these just almost like a little mushroom of skin. And you tend to get them around the neck. You can also get them around the armpit, usually anywhere where there's going to be a skin fold or a wrinkling or crinkling of skin. You can see these skin tags. And then the more complicated term I just mentioned, acanthosis nigricans, that's also at those same locations, like around the collar of the neck, where we all have a little bit of a skin fold. And then around armpits and groin, et cetera, the skin can get a little darker. And now, depending on pigment of skin pigment, that may be easier or harder to see the natural pigment of the person. But the skin will also also start to have a texture and appearance of like, crinkled tissue paper. So if we took a tissue paper, crumpled it up, and then opened it back up, that's kind of how the skin might look. So this darker, crinkled skin and skin tags, that is proof positive of insulin resistance. And then just if wondering, that's also imminently reversible. As the insulin resistance goes away, the skin resolves in that regard. So skin is kind of a. A window to the metabolic soul in that regard.

I remember when I was about 13, I started growing those skin tags. I had hundreds of them around my neck, armpits, and they used to sometimes get a little irritated or they'd bleed and.

Yeah.

And one day I was, I'm done with this. And I took, like, little fingernail scissors and I just cut all of them off because they have a tiny little stock. They don't really bleed when you do that.

Yeah.

And it just frustrated me. I had no idea what it was. I thought maybe they're warts. And I'm familiar with that as a sign of insulin resistance. And there's a lot of listeners right now going, oh, my God, I started growing those. They went away when I went into ketosis for the first time. And when I did the whole bulletproof diet thing, I don't have them, and I didn't have to cut them off. They just disappeared.

That's right. Yeah. So the nice thing about the skin in this regard is that it is so dynamic. We are growing and sloughing skin literally every moment. And so as the insulin levels start to come down, that hyper excitability of that layer of skin cells, because insulin basically starts to stimulate this kind of sporadic Growth. Insulin likes to grow things. That is not inherently bad. We need it. Without insulin, you die. So lest anyone thinking Dave and I are painting insulin as the villain. No, but the poison's in the dose, if you will, where we're talking about when it's gone beyond normal levels, insulin's resulting in this kind of frenzied growth of these skin cells. But again, the nice thing with the skin, it gets sloughed off so readily, literally all the time, that once the stimulus to keep growing goes away, I mean, give it like just week, just a couple weeks, and they're likely going to start literally, just, you'll notice them smaller, smaller, and they're gone as they just wear off. And now the clinical tests. Just for the sake of time and not getting into too much depth, I'll just mention two. One is just getting insulin itself measured.

Right.

This is, I believe, one of the greatest mistaken approaches of conventional clinical care. Despite all of its problems, we have a glucose centric paradigm of metabolic health. And the conventional clinician is content just once a year measuring someone's glucose levels. And glucose is a late signal that while glucose levels are staying normal over years and the person's developing hypertension and erectile dysfunction and migraines, it's insulin that's been the canary in the coal mine. Metabolically, it's getting higher and higher and higher. So look at your insulin. I generally outline three ranges. If it's 6 micro units per mil and lower, that is, that's really good. Solid sign, absolute green light, less than 6. Yep. And then if it's 7 to mid teens, I just say 7 to 17, then it's sort of, you know, hey, possible problem. Now, I, I, as a scientist, I don't like being a little soft in my wording. I like to be very clear and definitive. But insulin is a hormone and every hormone has its own ebb and flow. So the reason I kind of give a bit of an if with that range is if someone had their insulin measured and it's 11 or 12, they would say, oh, shucks, I'm busted. Yet that might have been just a peak moment where your insulin might have been kind of peaking up as it has a natural circadian rhythm to it. And so if it's in that middle range, you might be all right. All the more reason to rely on the second one. I'll just mention in a second. But you might not be. And then if it's high teens and beyond, absolute red light. Even the normal volatility of insulin shouldn't be getting that high in a, in an insulin sensitive person. So high teens into 20s, warning, you're insulin resistant. Red alert. Now the other metric is valuable because it's not as volatile and it is surprisingly accurate or a good predictor, a poor man's method. And that is the triglyceride to HDL ratio. So just take your fasting triglycerides divided by your HDL and that's going to be really good. If that number, there is some differences across the ethnicities, right? So the general rule is 1.5. If that ratio is above 1.5, that's a red light. That's a warning. Now in some other subsets of populations around the world, like East Asians, Japanese, Korean, that number ought to be actually closer to one. So it's a little more strict. So a triglyceride to HDL ratio of 1 is your cutoff lower the better. And then in blacks and I think Hispanics, it can be a little higher where the normal cutoff's going to be about 2.0.

Okay.

So it's going to be around that 1 to 2 range. If it's higher than that. Warning.

Metabolic dysregulation, does it change for men and women?

Yeah, that's a great question. No, no, because those numbers are pretty static across the sexes. It's funny you bring that up though, because the one lipid that isn't is free fatty acids.

Right?

If anyone ever measures free fatty acids, which is not the same, you know, triglycerides are what the liver is making or what you're eating. Free fatty acids are 100% a product of what the fat cells are breaking down. And women due to estrogens. Most gals don't appreciate this, but a woman at any moment is burning 40% more fat than her male counterpart.

What?

And you see this? You see this in her free fatty acid levels. Now, Dave, before we fellas claim defeat here and say we've been robbed, she's also putting in more fat at any moment too.

And so because she's eating more fat or because her.

No, no, not at all. Just because of sex hormones. Okay, so the. So estrogens are both stimulating the breakdown and the building up. So females just have a much, much higher rate of turnover in their fat cells, you know, so. So it ends up because the overall dynamic is she will have more fat on her body than her male counterpart, which she's supposed to. It's by design because she carries the metabolic burden of reproduction. She needs to have this kind of Metabolic insurance before she ever commits to the metabolic marathon of reproduction. But she's also turning it over it a lot faster. So she, her free fatty acids will be normally about 40% higher than what you see in a guy. But the other lipid measurements are generally going to be in that at least those ones are going to be generally in the same range.

What I found 99% of the time when people go on something like the, the bulletproof diet, which is clean, cyclical keto, the right kinds of animal fats, controlling the type of protein, toxins, all the stuff that I've been teaching for a long time. HDL goes through the roof and triglycerides drop, which is exactly what you want for this ratio.

It sure is.

And when I went to my, my first longevity doctor when I was maybe 29, it was a long time ago and I came in with that pattern. He just looked at me and said, well your, your lipids are technically disordered, but really good because, you know, my HDL is like, how did you get it so high? And why is, why is your triglyceride low? And it was because of the idea of intermittent fasting and things like that.

Yeah, you're doing it right. That's the right way to do it. And it is a consistent finding that you, you start to control carbohydrates, Triglycerides are going to come down because it's namely the elevated insulin that is spiking the production of triglyceride rich lipoproteins from the liver. So as carbs go up, triglycerides will go up. As carbs come down, triglycerides will come down.

I have a confession to make about an experiment I've been running for the past probably year. I am down to about 5% body fat. Like I am like crazy, crazy lean. And this is on using, you know, $26,000 clinical grade bioimpedance things and lots of different measures. And I used to weigh 300 pounds.

So isn't that amazing? What a testament to just how adaptable and dynamic the human body is.

It blows me away. And like my new book cover, I'm on there with my shirt off and I'm like the fat computer hacker who would never have, I didn't want pictures of me when I was fat. So I'm still kind of stunned by it. But here's the problem. 5% might be below ideal for longevity. I think closer to eight is where I want to be. And I'm really having a hard time putting on fat And I have half of a large bath towel's worth of extra skin for when I was obese. So I went in a couple of weeks ago, just posted about this on online, and they removed a passport size piece of skin from each side of my face and neck. This isn't from aging skin, this is obese skin. Probably aging, I don't know. And I've been healing really fast. But they're saying, Dave, we need some fat to put in with stem cells in your face to get the volume back. So I have been pounding the carbs, Ben, like 400 grams of rice and honey and fruit and watermelon, and I have not put on any fat. They found 20ccs when they like completely emptied my butt of all the fat they could find.

Oh, my gosh.

So how is it that I'm not getting fat on 400 grams of carbs? I'm doing 200 grams of animal protein A. Okay, I'm only eating good fats. What's going on?

Yeah, yeah. Well, so I. I can't state definitively, but generally there are going to be two essential variables that determine the growing and the shrinking shrinking of the fat cell. Now, your audience is savvy enough to know that there is more than just one variable, which is the traditional view being that it's just purely calories in, calories out. That is so easily disproven. No, right now, but. And I'm not saying, like, just so everyone knows, I'm not saying calories don't matter, but that is the only message anyone ever hears that people think. That's what I'm saying. And if I kind of claim any authority, and I'm loathe to do this, I have such a general disregard for higher education and terminal degrees, like a PhD, which is ironic, I know, but I'm surrounded by PhDs, and so I've seen how dumb many of these people are, and I hope I'm not one of them. And I don't necessarily just mean my colleagues here. I love them all dearly. But if I'm going to make any sort of stake a claim here, I have a unique PhD. And you noted this in the introduction. It's very uncommon. There are only, I think, two institutions on the planet that grant a PhD in bioenergetics. Bioenergetics is a particular niche of research that combines the metabolism, biochemistry and physiology, but with a heavy focus on thermodynamics and the relevance of thermodynamics in living systems. Because, lest anyone has forgotten, thermodynamics was originally posited as a view to make the better steam engine that it is in the realm of physics. And it is an odd or it's an awkward fit to try to fit principles of physics in principles of biology. I actually think that I'll make this kind of a bold claim. I consider the introduction of calories into biology as part of what got us where we got it wrong. It so thoroughly distracted us from, I think, what matters most that it actually brought us to where we are. I think the whole war on fat, in part was born because of this improper introduction or invocation of thermodynamics. Now, having said, all that calories matter and those carbons need to be accounted for in some way. But a cell, like, especially a fat cell, it needs to know when it's time to eat and when it's time to break down. And the fat cell wants to be. And everyone. Pardon me if it sounds like I'm being silly. I am, after all, a professor who teaches 18 year olds, so I have to sometimes be a little juvenile in my description of things. But the fat cell needs to know that it's playing nicely in the entire neighborhood of the body, that it needs to know, okay, what are the demands of the brain right now? What are the demands of the muscle? There's no direct nerve that's connecting them. It's hormones that generally will tell the overall orchestra when it's the woodwinds section to play, when it's the brass section, or when is it time for the muscle to be needing energy? But you couldn't. You don't want muscle to be exercising and pulling in energy to break it down at the same time. Fat is taking in energy to store. The body, in its overall balance of metabolism, wants to balance out the two parts of what is metabolism, Anabolic versus catabolic. Insulin is the hormone that sends that signal. So this is my really long winded way of just saying, I have right now, down the hallway in my lab, fat cells growing in petri dishes. Like literally right now, I'm not even being hyperbolic here. Those fat cells, when we first plate them and they're sticking to the cell, to the bottom of the dish, they are in a bath of tons of calories, tons of fat and tons of glucose. Everything a fat cell wants in order to grow, but it stays small until we do one single thing, which is add insulin into the culture. The moment insulin comes into that little culture media we call it or that bath. Now, the fat cells would say if they were Part of the greater whole. Ah, it's time for me to eat. This is my signal that it's time to store energy rather than break it down. And now we look. If we look at those fat cells just four to six hours later, they're actually thicker, chubbier. If we look at them six hours later, still, they're bigger again. So all of this is just to say that there must be a stimulus that tells the fat cell to grow, which is elevated insulin, and then there must be sufficient calories to fuel that growth. You cannot have one without the other. And just to really put a fine point on that, if a person had high insulin and low calories, they will die because they would become hypoglycemic and there would be no ketones being produced because the high insulin would be inhibiting ketogenesis. And then the brain would have been deprived of its two fuels and the body would shut off. The brain was shut off. Now, in contrast, if insulin's low and calories are really high, what happens then? Now the person is burning up almost. They burn to death, where their metabolic rate and their ketogenesis is unstoppable because there's nothing to tell the body to stop burning energy. And so they die from ketoacidosis and hyperglycemia. But this is a scenario which is so real that. And it works, where you can eat as much as you want, that people with type 1 diabetes, some of them have learned and are so tempted that they can deliberately underdose their insulin level and be into a state of ketoacidosis and massive hyperglycemia and feel miserable and wretched. And yet they will be as thin as they want. Just everyone imagine the temptation. You know, they don't have to vomit up their food. They don't have to starve themselves through traditional anorexia. They can eat everything they want. They can enjoy the sensation of eating it and swallowing it and digesting it, which has all of its own gratification. And all they have to do is not poke themselves with a needle and inject their insulin. That's a condition called diabulemia. And all of this is just to say there are two parts. The fat cell must be told to store insulin or to store fat via high insulin, but it needs sufficient calories to fuel that growth. It's one thing to tell the fat cell, let's grow. Then the fat cell has to grow.

So low insulin and high food intake equals thin and lots of energy. But I guess they feel like crap.

Oh, yeah. I mean, they. Yeah, you can read case reports where the. The people will say, like, I felt. I feel like I'm dying, but I want to stay thin. Wow.

Yeah. That's unhealthy.

I mean, just imagine.

Yeah.

Yeah.

I did notice when I was testing out the. The edges of the recommendations before I published the bulletproof diet. And I published that in 2014. I published online. In maybe 2013. I went for about a year, and I was eating 4,500 to 5,000 calories a day on purpose, more than I wanted, like, forcing myself to do it, eating no carbs, and I was sleeping less than five and usually less than four hours a night on purpose. Like, I'm going to set myself up to get fat. I'm going to prove that I don't get fat the way I should. But I kept losing weight. I grew abs for the first time on. In crazy amounts of this. I know my insulin was low because I had it measured. It was actually pretty darn low. Don't remember the number off the top of my head. And that probably explains what. I didn't feel like crap until kind of maybe halfway through. I started getting cortisol effects where I would wake up dozens of times a night. My sleep quality went down. You start getting reductions in testosterone, thinning of hair, and all of that, and I stopped it. But I meant to do it for a month to just make fun of the calorie people, and I ended up doing it for a lot longer because, like, I'm actually in a really strong state of high performance. Why did my brain work so well when I did that, at least for the first six months?

Well, Dave, so you brought up a lot of stuff, and I don't want to not answer the question you started with, which is why you're not gaining fat. So let me come back to that first part, and then to answer this part right now. Yeah. I mean, ketones are the preferred brain fuel. One of the notions I attempt that I need to disabuse my students of is that they've been told the brain prefers glucose, and you need to eat this much glucose. There's multiple things wrong with this. Not true. Not true. But just to really establish the relevance of that, I showed them research from Dr. Cahill where you can take someone with a glucose level of. I'll use the same kind of units here. Let's say 5 millimolar, which would be kind of 80s milligrams per deciliter. And if their ketones are at 1 to 2 millimolar so less than half of what the glucose is. The brain's already getting most of its energy from the ketone. So don't tell me the brain prefers glucose. If anything, the brain has a preference for ketones, which Dr. Richard Veach and many, many others, my own lab has reported papers on this. It enhances mitochondrial performance. For every oxygen unit of oxygen that the mitochondria are consuming, when they're fueled with ketones, they're producing more ATP.

Yes.

So what we described that in my publication is that the ketones were resulting in a tighter state of mitochondrial coupling, which is how much energy am I breaking down in order to produce this energetic molecule, ATP? And it was better. Now, in your case of what you're trying to do now, one of the reasons I point the finger at carbs is because of what it does to insulin. And so in your situation, you are either now so exceptionally glucose tolerant that even though you're eating hundreds of grams of carbs, if we were to act, you're clearing it so quickly that it's never resulting in substantial insulin spikes or. Well, I, I, that's it. You're just that insulin sensitive and glucose tolerant.

HbA1c went up in a way that I don't like. So I'm, I'm on low carbs now.

Yeah, but do you, but are you still in ketosis pretty often? Have you been measuring your ketones during this?

Not with a finger stick, but I just use exogenous ketones several times a week. I, I know there's ketones present of a meaningful portion of the time.

Well, I would be curious if you like, in a morning. So one day, like on, on, on a. Today you ate 500 you 400 grams of carb, but tomorrow morning, if you measured your ketones, if you are in ketosis, then your insulin's not really going up that high.

Interesting.

Not only. So the other point I meant to make is that you're either, it's a combination of you're super insulin sensitive and you're just maybe so physically active. I have known really active individuals who eat hundreds of grams of carbs and they're still in ketosis the next day because they're just burning so much of the glucose. And the magic of the working muscle is that it can pull in that glucose without the need for an insulin spike. As I mentioned earlier, insulin wants to store energy, which is antithetical to exercise, which wants to break down energy. It wants to break down what's been stored. And so exercise quickly lowers insulin Due to the sympathetic stimulation, basically, the body starts moving and then the brain starts to tell the pancreas, hey, you gotta shut down insulin production. And it does so very quickly. And so all of this can combine that if a person's already insulin sensitive, which you certainly are, combined with high levels of physical activity, if you aren't getting elevated insulin for pronounced periods of time, it doesn't matter if you're eating those calories, you're not going to store it as fat.

Even if my blood sugar goes up, but my insulin isn't going up, you're.

Saying, yeah, well, it could. That's exactly right. Yeah. So glucose is not a perfect surrogate for insulin as much as we wish it were. Yeah. It is important because while we can measure glucose so readily, it is. We are years away from having a continuous insulin monitor and they're not the same. Like, for example, if Dave were to take 100 grams of carbohydrate and then immediately go exercise, we would see that spike it. Depending on how intense the exercise is, it may even stay high for a while. But no insulin was required during that exercise. As it starts to come down, it's not because insulin went up, it's because the muscles are pulling it in on its own. Because again, when the muscle contracts, it has an insulin independent way of opening its doors. You'd mentioned MTOR earlier, and I know you're familiar with MTOR's opposite, which is AMPK. When you start to contract and relax the muscle, it's flooding the muscle cells with calcium. Calcium, as it goes up, will activate an enzyme called calcium calmodulase kinase or camkinase. So a calcium activated enzyme, Camkinase, will then activate AMPK. AMPK will then activate AS160, which activates GLUT4. And now we've opened the glucose doors and we've been able to pull in that hungry muscle. Basically says to insulin, hey, I'm too busy to wait for you to tell me what to eat. I'm just going to eat this because it's here and I'm going to pull it in.

This is why even going for a walk after you eat carbs or doing, doing some squats, it doesn't really matter, not even weighted squats. Just do you have 30 air squats and you can watch? I, I've used a glucose monitor for long periods of time and you can see, oh yeah, eight carbs. It's going to go up and then you do a little bit. And if you actually do a real workout with weights or something. And real resistance, you're not going to get much of a spike at all.

Yeah. So that might be part of your problem. Honestly, Dave, for you to gain weight, you may have to start changing so many habits.

I don't exercise that much. I do really good exercise with AI stressing the system from the upgrade lab stuff. I do about like 20 minutes a week of real exercise. And it's carefully scripted to exhaust and then recover very quickly. So I don't think my volume is high, but my recovery is high and my intensity is high. So I'm like, I'm a weird robotic cyborg biohacker guy testing out weird stuff. And I just, like, you would probably know why. Is it possible to have my average glucose go up and to eat ridiculous amounts of carbs, sometimes more than I want, and then to not gain £1? And it sounds, it sounds like you, you figured it out.

Yeah, well, I, I think that if we'd really need to know what your insulin levels are, it's entirely possible that your fasting insulin levels are still in an exceptionally good range and that what you think is a big insulin spike, it could be much more modest than you realize. And if that's the case, then you're kind of getting into that physiological scenario of what we see with diabulemia, which is that the insulin levels are getting so low that it's just incompatible with storing fat.

That makes so much sense. Okay, I want to touch on one more thing about calories in, calories out. Because you and I have both been trolled by these, like angry 25 year olds, you know, cancel out a Snickers bar with a Diet Coke kind of people. And I, I just laugh like, well, if calories counted, there's a million calories in a gram of uranium. And they go, but you have to be able to absorb it. I'm like, oh, thank you. So calories don't count, Calorie absorption counts. And then they start twitching usually, which helps them burn more calories, which probably is good for their weight loss. And then I say, well, do you know about zero? And like, no. Well, it's a drug derived from mold toxin that's 10,000 times more estrogenic than normal estrogen. And if you give it to a cow, which ranchers do, the cow will get fat on 30% less food. So if the drug can exist and there's tens of millions of dollars being spent because it works. It's not about the calories. I'm not saying that they are relevant in some way. But this idea that I'm going to somehow know how many calories I burned without being in a calorie chamber, that's nonsense, because only half your calories are from moving. The rest of the stuff is respiration, temperature, humidity, stuff that no one's going to measure. So you don't know how many you burned and you don't know how many you ate. Because the dumb little apps, like, as a guy who makes, you know, $100 million plus of food things, the number of times that I've gotten in trouble because when I buy a fricking cashew, the calories per gram varies based on the time of year. So you can't even say a gram of cashew always has the same calories. And so my labels have to be within a very narrow window. And so it's complete fantasy that we can measure what we're taking in or what we're putting out. Which is why I'm like, this is just a distraction. Which is what you've been saying as well.

Well, yeah, and you can see why I feel so strongly, as much as I appreciate thermodynamics. But the problem is we don't eat heat. Let me. A calorie is a unit of heat. We don't eat heat. Like does does. If we, if we eat a warm Snickers bar, is that. Does that have more calories in a cold Snickers bar? You know, because if it's. If it's just pure calories and it is, then drinking a hot coffee, you know, or that's not a good example, but it's not calories that matter. In an ideal world, if we really wanted to have a food label that gave an idea of how fattening this food will be, which is what the calories are trying to do. The whole reason we have calories is this idea that, hey, you need to control your body fat, so look at these calories and count them all. It is such a fool's errand. For all the reasons you mentioned, it is impossible for the average individual to capture every calorie coming in, let alone every calorie going out. Now, by going in, not only did you mention how even on a label, it might have gotten it wrong, but you don't know how much you're absorbing. You don't know what the thermic effect or the caloric cost of digesting and absorbing that food is. And again, it's not units of heat that you're getting. So in the ideal world, if we deemed it necessary to have some metric on a food label, it would be some combination of how much is this going to spike your glucose and how much is it then going to spike your insulin? How many other carbons are coming with it? Because dietary fat matters if insulin's high at the same time, and because then you're storing those carbons very readily. But it'd be some kind of algorithm that would give, like a fat index or a fattening index, rather an obesogenic index that would say the combination of carbons or calories, if we have to use that term. And insulin spike means that what you're about to eat is going to be more obesogenic than, say, something else. That would be more of an ideal scenario because, again, it's not units of heat. Calories don't really work in that sense. But one other comment on this that I thought while you were explaining the scenario earlier, when insulin comes down, as I've mentioned now a couple times, it is so antithetical to the body storing energy that someone will say, well, where does that energy go? You have to account for it. And I agree that you have to account for the carbons. They need to go somewhere. But the body, it is so antithetical to storing carbons when insulin's low that the body has these release valves, these pressure valves, in two forms. One is that when insulin is low, metabolic rate goes up. We've known this for 100 years. By studying people with type 1 diabetes, there is a substantial elevation in just resting energy expenditure, just the cost of living. The body's just running hotter, the engine's idling faster. When insulin's low, my lab published a report finding that part of it is because of the effect of ketones. We found that when a person was in ketosis, and we did humans fat biopsies, that their metabolic rate from their fat tissue was three times higher than when they weren't in ketosis. So there is just this increase of metabolic rate in fat tissue itself. So when insulin comes down, metabolic rate goes up. That's one part of it. The second part of it is that's the wasting in the form of heat, what I just described. Then it's wasting in the form of ketones. Everyone remember ketones have a caloric value that is almost the same as glucose. And when you're in ketosis, you are breathing out ketones, which is to say you're breathing out calories. Wow. And you're urinating out calories because you have ketones that are getting excreted in Your urine. And remember, ketones have a caloric value. Or in other words, carbons that could be used.

That's amazing.

But we're wasting them.

How did I not know that? I never thought of it. So that's one of the benefits of intermittent fasting or being on a ketosis kind of diet. You'll breathe out calories and you'll pee out calories.

Yeah. I mean, how did I miss that? The collective effect of all of this could be as high as 5 to 600 calories. Holy crap. I mean, that's a lot of stair stepping. That's a lot of exercise to try to get. I mean, anyone, next time you're working out, see how long it takes you to get to 5 or 600 calories burned as opposed to just being in a. No, it's so long. It's so hard just being in a ketogenic state. You're doing it without even thinking about it. This is why you and I are able to say, don't count calories if you're hungry. Like, to the average person who wants to lose weight, the traditional view is cut your calories. But if you're not addressing your insulin, that's just going to promote hunger. Hunger always wins. Before you know it, you'll be right back where you were. So let your first step on your weight loss journey be, I'm going to lower my insulin. Calories will take care of themselves. Just control carbs. Eat good protein and good fat. And when you're hungry, eat. If you're not hungry, don't eat. And with this plan in mind, insulin will come down again. Calories will take care of themselves.

Are people going to lose muscle mass if they go into ketosis and they lower insulin?

Oh, that's a great question. I'm happy to answer it because I can rely on some good research. 2 thoughts come to mind. One was the Scottish man, I think, who fasted for 384 days and then worked from my own lab. So let me start with the Scottish guy. This is a documented case report where he literally fasted for more than a year. And Dave, something I actually thought about earlier when you were describing kind of your own feeling and then the cortisol, it's for people to understand the difference between a fast and starvation.

Yes.

The difference between those two is fat tissue. If you have fat tissue to burn, that means you're making ketones, which means you're feeding the brain everything it could ever want. As you start to run out of fat now, you run out of ketones. Now, the brain has to rely on glucose. And what's the main source of glucose? It's going to be amino acids in that state, not in the normal state. In the normal state, it's most of the source of glucose is coming from lactate, by the way. But when with long term fasting to the point of I've run out of fat tissue, now, the body starts breaking down muscle to get those amino acids to convert those into glucose, and cortisol helps it happen. Now, in this guy, he had so much fat because he was morbidly obese, he didn't lose muscle. He maintained his muscle mass throughout this entire fast. Now, in my lab, we published a report finding. In fact, it was right after we did the fat cell study, where we looked at how fat cells respond to ketones by increasing the metabolic rate and there's a lot of wasting of energy. We did a comparable study, not quite as strong. We didn't use humans, but we did a comparable study with muscle tissue and ketones. And we found that ketones enhance mitochondrial coupling of the muscle. So the muscle's getting more efficient with its use of energy. And the muscle cells were more robust as we kind of insulted the muscle cells with some chemical stimuli to kind of knock on them and hurt them a little bit. When muscle cells were fueled with ketones, they were more rigorous, they were tougher, they were more viable and more resistant to injury, Suggesting that at the end of it all, people have long said that ketones defend muscle. Now, what they meant by that was that if ketones are up, then there's going to be less breakdown of muscle because we don't need those amino acids for gluconeogenesis, which is true. But my lab added evidence to this, which is to say that ketones really are defending the muscle. Because when muscles are fueled with ketones, they're literally tougher, they're harder to kill.

These are really good arguments for cycling in and out of ketosis. I found that when I stayed in ketosis for long periods of time that I would develop insulin resistance. This seems like a common occurrence, so that's one of the reasons I recommend cycling. So talk about insulin resistance and people in ketosis for long periods.

Oh, I'm so glad I have a chance to bring this up. Yeah. So, Dave, you'll not be upset for me to say that's not insulin resistance. Oh, cool. What people are describing in that case of a ketogenic diet causing insulin resistance, it's not insulin resistance. Insulin is working exceptionally well what it is is an acute glucose intolerance. Now let me sort of provide some interesting context here. People have heard of the concept of metabolic flexibility, which is this idea that when you eat a mixed macronutrient meal with carbs, you go to glucose burning mode and you can detect this. And then when you enter a fasted state, about five to six hours later, because insulins come down, you go to a fat burning state. So the body shifts between sugar burning and fat burning. Some scientists at the University of Pittsburgh, years ago, 25 years ago now, I think documented this concept of metabolic inflexibility, which is where there are people who have insulin resistance because that's the cause of this, that when they eat, they're in glucose sugar burning mode. When they're fasting, they're still in glucose and sugar burning mode because their insulin is still elevated, which is insulin resistance. So they're stuck in sugar burning mode. Now, in the long term adherence to a ketogenic diet, I like to say you kind of have an inverse metabolic flexibility scenario where it's almost like the body is stuck in fat burning. Now it's not. What has actually happened is if you've been in a long ketogenic diet, actually it doesn't even take long. Even if a person fasts for 24 hours, what I'm about to describe happens to them as well. So if someone goes and takes an oral glucose tolerance test, they go drink a bunch of glucose, you measure a glucose curve and you see it come up and down and say about two hours, it's back down to about 100 milligrams per deciliter. That's a good response. Now if this person were to then adopt, well, even fast for 24 hours, let alone be in a ketogenic diet, if they take that same oral glucose tolerance test now, you would say, wow, my glucose went higher and it took even longer to come down. It didn't come down until three hours or three and a half hours. The temptation is to say, I'm insulin resistant now, because if you were looking at a person with type 2 diabetes, that is what's happened. But that's not what's happened in this person who maybe just fasted a little too long or is on a ketogenic diet. In that case it's because of a lack of preformed insulin in their beta cells. So basically, when we eat carbs, the insulin, the beta cells want to be ready and they literally have a bunch of pre packaged insulin in the beta cells stored like on the shelves. Behind me, ready to go. Here I am in my beta cell office. Insulin glucose comes up. I get a knock on the door. I know, okay, I got to address the glucose. I'm going to start shipping out all of this insulin I have made right now, which is called the first phase insulin release. But I am constantly monitoring the glucose. I know this isn't going to be enough. And so at the same time I've been shipping out my preformed insulin, I've started making more insulin. That's the second phase insulin release. When a person has fasted too long, well, 24 hours or so, that's not too long. But prior to an oral glucose tolerance test it is. Or they're on a ketogenic diet. The beta cells are so efficient, and I'm sympathetic to this because I hate clutter, that the beta cells basically start to say, hey, I got all this stuff on my shelves here and I'm not using it, I'm just going to get rid of it. And so it literally breaks the insulin down to its base amino acids and then just recycles them and does anything it wants, which with them. But it starts to think, I don't need all this insulin. And then all of a sudden, hold on, red alert. We need glucose has just flooded the system. Oh crud. The beta cell says, well, I don't have all the insulin made, so there goes that first phase insulin response that I'd normally have. But I still have the ability to make a bunch of insulin. It's just going to take me a little longer. So body pardon me, beta cell for being too efficient. It's going to take us a little longer to clear that glucose. But says the beta cell, to finish off this weird story, if you do this again within a 20 hour period or so, I'm going to keep this insulin here just in case we do it again. So my long winded way of saying it's that there is become an acute glucose intolerance because of a very temporary reduction in insulin on hand preformed. And so if a person is on a ketogenic diet or they're going in for an oral glucose tolerance test and they think that they're going to crush it by fasting for 24 hours, you've actually set the stage to get a false positive or you're going to fail that glucose tolerance test or get a worse score because you haven't eaten carbs recently. So eat some carbs eight hours or so before you go take the test. And it doesn't have to be Sugar. Just eat some starches, and then the beta cells will say, ah. Okay, maybe we're gonna start getting into carb consumption again. I'm gonna hold onto some insulin so that when we do this test in 8 or 12 hours, I'm gonna be ready for it. And then you'll pass it with flying colors, because a ketogenic diet will improve insulin sensitivity exceptionally well. Remember, Dave, everyone remember the way I described insulin resistance earlier applies every time we invoke a. The term insulin resistance, which is insulin, will be high. If insulin is low, it is impossible for the body to have insulin resistance. So this scenario isn't reflective of insulin resistance, but just rather a temporary state of glucose intolerance, because the body's kind of been saying, well, I'm not sugar burning. I'm fat burning. Oh, hold on. Wait. You want me to go back to sugar burning? All right, well, I wasn't quite prepared, so pardon me while I just sort of make some adjustments, and I'll be better prepared next time.

So you just taught people how to preload insulin? If you're in ketosis and you're going to do a life insurance test, that.

Would be important 100%. And I want people to know that, like, if I imagine, you know, a pregnant gal who's been in a ketogenic diet to help with her PCOS and get pregnant, now she has to go in for her oral glucose tolerance test. You. You want to eat some carbs in at least some period of time before you go in. 8 to 12 hours. Hours, just to have that insulin on hand, and you'll be just fine.

Oh, that's such a gift. Thank you for sharing that. There's some other things that affect insulin and insulin resistance, like circadian rhythm. We know melatonin going up will make you insulin resistant. We know that at night, you're insulin resistant. So does it matter when we measure our insulin and when we measure our blood sugar and when we eat?

Yeah. Yeah, it does. In fact, tragically, measuring insulin in the morning is probably one of the worst times. And that's why I kind of described that there's that bit of that gray area, that kind of orange light range or yellow light range, where insulin might be a problem or it might not be. And I actually kind of bake that into the formula because of the morning volatility, that when we're waking up in the morning, we will have higher cortisol levels naturally, which starts to just mobilize the glucose to get ready for the brain to come back online. If you will. You know, as the body starts to wake back up and get alert. But also insulin can start to climb in response to that glucose climb. And so morning is one of the worst times, but it's the most convenient because we're fasting overnight. We need a fasting state. If in an ideal world we wouldn't measure fasted blood levels until, you know, late morning or early afternoon to let.

That pass, can you adjust for that? Like, let's say you, you do your insulin test in the morning and it should. You just subtract a point off of the morning score to get a more accurate.

I don't know. I don't know. That's a really, really good question. That's never been allowed.

This is. This is.

Yeah, you'd want to. I mean, what you'd want to do is take that same person, measure their morning, and then measure their afternoon consistently across a group of people and then find out that, okay, here was morning, giving us a little bit of that false positive range or a false concern. Here was afternoon. So if we make this kind of algorithm, rhythmic adjustment, it allows us to get the morning, which is the easiest time to do it. Everyone wants to do their fasted tests in the morning so they can end their fast. I get it. But yeah, it would be nice to be able to kind of have an adjustment on hand to say, okay, well, actually it came in at 15 microunits per mil, but based on what we see across the population, if we were to measure this four hours later, it would have come back down to seven. Okay, so you're actually doing great. Yeah, that's never been done.

Wow. Well, this seems like something your lab would be uniquely suited to do.

Yeah, we could hope for that.

We've talked about doing squats after a meal or going for a walk to lower blood sugar, which ought to also lower blood insulin, we hope. Are there other non dietary things we can do? The biohacks, like red light therapy, pulsed electromagnetics, cold plunges. What do those do?

Yeah, so the only one I can speak to is some authority is cold plunge. Although I think everything you've just mentioned does help. Including just sauna. It's the interesting quirk of just temperature extremes with cold immersion. Yeah, I mean, the results are really remarkable across the board. And I am an unapologetic advocate of cold immersion. But there is something to be said for there are two mechanisms that cold therapy will engage. One, which is shivering, induced thermogenesis, and then it's mitochondrial uncoupling and the the brown fat being the most famous example of that. But with the shivering, of course, the whole body contraction of the muscles, that's really, I mean, you are exercising, you are contracting and relaxing muscles in order to generate heat. Well, that heat has to come from burning something and a lot of that something's going to be glucose. Now, at the same time you're shivering, you're also sending a signal to mitochondria, particularly in fat tissue, that hey, mitochondria and fat tissue, I need you to become less efficient, which, which is to say I need you to burn energy to create heat because heat is a waste product, you know, and, but when the body gets cold, it actually gets a little, well, wasteful. It starts to want to burn energy just to create more heat. And so you have this uncoupling where the mitochondria, it's basically like you're, you're, you're revving the engine in your, your car, but you're keeping your foot on the clutch at the same time. And so you're getting a high RPMs, but you're not getting any speed, you're not moving. So you've uncoupled the burning of the fuel in the engine with the movement of the car, you know, which is not the same that I mentioned earlier. Earlier I mentioned that ketones help the muscle be more coupled. In that case, now you're revving the engine and you're seeing movement with the speedometer. But with cold and with ketones, generally you're uncoupling it where you're revving the engine but you're not moving anywhere. You've uncoupled those two actions. And so cold therapy is an incredible way. But there also are kind of other hacks, like apple cider vinegar is surprisingly effective. But you were kind of saying non dietary. So. Yeah, of all of those I personally leverage whenever I can take advantage of cold immersion and sauna. They're exceptional in this regard.

I do them a lot. The other thing that I notice has a big effect on my blood glucose stability, which is a proxy for insulin, is darkness at night. So I'll wear the truedark glasses that trick the brain into thinking that it's nighttime. And if I wear these for an hour or so before bed, especially if I'm traveling, I have much more stable blood glucose the next day. And I think just darkness at night to reinforce the C and rhythm works.

Yeah, well, it does work. Just to put a really clear statement on that. One of the reasons East Asians have Such unexpectedly high levels of glucose is because that these are cultures that have the highest bright blue light exposure later into the evening. That is one of the reasons. There are some other quirks of physiology across ethnicities, but it is an absolute consistent feature of East Asian culture. Lots of bright blue light into all hours of the night, which absolutely will disrupt circadian rhythm to such a point that you'll have higher cortisol levels the next morning and in turn higher glucose volatility.

Environmental toxins and insulin resistance. Is there a connection?

Oh, yeah. Oh, for sure, yeah. In fact, in my, my first book, you mentioned my how not to Get Sick, which is this one over my shoulder, one step over outside of the cameras, my why We Get Sick book, I actually devoted a small section to, as I talked about the origins of insulin resistance to describe some of the evidence, looking at certain molecules from like plasticizer agents and detergent agents and more and more, even certain pesticides and herbicides.

Yes.

So these are all chemicals that have varying direct or indirect effects at promoting insulin resistance, where the direct effect is such like lectins have a direct effect as a kind of food anti nutrient toxin. Lectins have a direct effect of causing insulin resistance, whereas some of the detergent molecules like diethylstilbestrol, it's not going to have as much of a direct effect, but rather an indirect effect by promoting the growth of the fat cell. And when fat that comes back to the kind of slow insulin resistance that I alluded to earlier, where when the fat cell gets too big, it starts to generate its own form of insulin resistance, which just as an interesting aside, it actually starts to promote insulin resistance to try to prevent further growth, but in the process starts to kind of spread that insulin resistance with a couple different signals throughout the body. So, yeah, I mean what we eat and drink and even, even breathe. We've published papers, working with my colleague Dr. Paul Reynolds, we just published a paper late last year actually finding this was an animal study where when these animals were exposed to diesel exhaust particles, even when they ate the exact same amount of food as their litter mates, just exposed to normal room air, their fat cells got significantly bigger. So once again, our little rant earlier. Don't tell me it's all about calories. There are these signals, even some things we breathe, that are going to influence the overall dynamic energy storage, the balance of metabolism. So yeah, there are. Unfortunately, we live in a bit of a dirty world and where people are able to mitigate some of these risks. Now, I know that some people feel A little overwhelmed. I still firmly believe macros matter most. If you can just focus on one thing, focus on getting your macronutrients, which.

Is give me the right ratios for macros.

Yeah, well, for me it's very simply control carbs. So don't get your carbs from bags and boxes with barcodes as much as you can whole fruits and vegetables, depending on your overall scenario. And then it's prioritize protein and don't fear the fat that comes with that protein and just don't fear fat in general. But as a reminder, in nature all protein comes with fat, there's no exception. So every as much as we love protein, people talk about protein, there's always a little part of me that says, and don't forget about the fat that is supposed to come with that protein. The body digests it better. The combination of the two is more anabolic than just the protein alone. So macros matter most and then all these other kind of more micro influences. That's not to say they're irrelevant, they matter. But thankfully if a person is eating fewer carbohydrates, that is the most offensive macronutrient source. Now you can have like proteins, depending on the source, they can also be somewhat influenced and a little polluted, although animal proteins have much lower levels than plant proteins do. But even still, it just as a person controls carbs, you end up inadvertently getting rid of things like the anti nutrients. You're going to get far fewer levels of pesticides and herbicides just as you're eating less carbs, because those are the main vehicles for those kinds of things. And whereas fats and proteins have generally gone through the animal and the animals cleaned out some of those things on their own, or they're stored in other tissues that we don't eat as much of. Certainly the muscle is going to be one of the cleaner tissues in the body. So. So that's why a person, I would say, don't expend all your energy depending on where you are at and what your financial capabilities are and your bandwidth to focus on this. If you are just managing your macros, you are, I believe, addressing the variable that matters most. But these other things do matter. But don't let that overwhelm you would be my advice.

I like to outsource my liver and kidneys to cows.

That's right, yeah. Well said.

They pre filter all of the plants for me so then I can eat them. And the results are profound when you do that. Or it can be sheep if you're not into cows or whatever.

Yeah, no, no, but you. You and I. Yeah. Ruminant meat. So if it's a multi. A polygastric animal, that, to me, is some of the best meat you can get.

So we're. We're aligned there. One of the potential causes of insulin resistance is excessive damaged omega 6 fat baths because they go into the cell membrane and they mess with things. How much of this is caused by carbs versus just eating all this canola, corn, soybean, and all those things.

Yeah, yeah. So, Dave, you are. You are putting me in a position where I am going to have so the. I. I don't mean for this to sound disparaging in all sincerity. I don't.

You can just bear with me. Like, I'm curious.

Well, no, no, not you even. Not you. But like, I. I don't want. Like this. When I say seed oil crowd, I don't mean to, like, put everyone in a little tribe here, but of course, there are people who. They will say, Ben focuses on carbs. Well, that's not the real issue. It's seed oils. I just want to remind people that my main focus is insulin resistance. It is not other problems. So within the direct realm of insulin resistance, I will claim that hyperinsulinemia is more of a problem than. Than seed oils. Now, at the same time, I want someone to know that if I'm actually talking about, like, liver fibrosis, seed oils are actually probably more problematic. Cancer and damaged mitochondria that feeds cancer cells, seed oils are probably more problematic. So as much as it seems like I'm disrespecting the seed oil view, I actually am not. I'm just trying to kind of stay in my own own lane where I really am kind of more of an expert.

I respect that greatly. And so it's possible that eating excessive seed oils contributes to insulin resistance because of cell membrane changes. But that's not what you're studying. You're studying the effects of insulin directly on this.

Yeah.

And so acknowledging what you're an expert in and not going into areas that you haven't studied, I can only respect that and.

Good, good.

Yeah, yeah. In my case, I think it's advisable to minimize those. I haven't eaten seed oils.

Totally agree.

In a long time.

Totally agree. But let me. Let me just kind of answer the way you framed the question, because I do have thoughts on it. So the connection between seed oils and insulin resistance, I do not believe that it's a direct effect.

Wow. Okay.

For example, you can Incubate cells with linoleic acid and they will not become insulin resistant.

That's a pretty good piece of evidence.

Yeah, it is. And I want someone to hear because I've literally done that. I've incubated cells with all kinds of stimuli. And then you just. It's a simple set of experiments. Now I'm going to incubate with some insulin for 10 minutes. I'm going to harvest those cells, and now I'm going to look at the signaling, the protein phosphorylation states across a handful of proteins. That will tell me, okay, how well did insulin work? So with a high degree of authority, I can tell you linoleic acid does not cause direct insulin resistance.

It's fried for two weeks and then you do it.

Okay, so now we're not even putting on linoleic acid. So this is a really good point. If you start to just put on like the peroxides of. Of this, that starts to change thing where it is. But just so people appreciate how difficult it is to work with these molecules. They are so reactive that they just become toxic cytotoxic, where the cells just start to die. And so you can't really even to try to find the right dose is actually problematic.

So the highest expression of insulin resistance is death?

Yeah, yeah, that's right. Yeah. I mean, so what if you're insulin resistant, if you're killing all your cells? So that's a really, really good point. That as much as I've just been talking about linoleic acid, the conversation really ought to be looking at the peroxides. So that's a really, really important consideration that I need to keep in mind. So linoleic acid alone doesn't appear to cause insulin resistance. The degree to which its peroxide metabolites do, I don't know, but I bet it does. I bet there's an effect there. But even still, the way I describe the relevance of linoleic acid is through what it does in the fat cell. So it takes me back to the fat cell, because linoleic acid is unique, that you can track it. If you eat more of it, you store more of it. And this has been shown in fat tissue from humans. When linoleic acid gets converted to these more reactive molecules like 4H and E in a fat cell, it forces the fat cell to grow through hypertrophy rather than proliferating through hyperplasia. And the difference there is that if you have more fat cells but they're small, then you're insulin sensitive. From the level of the fat tissue at least, because small fat cells are insulin sensitive and happy fat cells. They're very anti inflammatory as well. Linoleic acid converted to 4h and e, 1 of the more common reactive metabolites tells the fat cell, hey, there's no proliferation happening here. You're just growing through hypertrophy. The hypertrophic fat cell is an insulin resistant and pro inflammatory fat cell. So when I talk about linoleic acid or seed oils with some caution, I don't like to say that they're a direct cause of insulin resistance like other ones are. Insulin is a direct cause. Inflammatory proteins are a direct cause. Like in that same cell culture, I can put on cytokines, they're insulin resistant in minutes, stress hormones. I can incubate those cells with cortisol or epinephrine, they'll become insulin resistant. But if I do it with linoleic acid, like I said, it's not quite the same effect. But with all of the myriad metabolites that can be generated, it is very possible that some of those could have a direct effect. But when I talk about it, I try to be a little cautious and just say, well, it might, but I don't know if it's direct, but I certainly believe it's an indirect because of its effect on the fat cell.

That is so academically honest and commercial. And it sounds like you don't eat a lot of linoleic acid on purpose either because it's probably not good for you.

But yeah, well. And again, when someone's obeying that first rule, the control carbs. I believe the vast majority of the linoleic acid seed oils that people are getting are coming from bags and boxes with barcodes. So if you're just controlling carbs and eating less of that, the good news is your linoleic, your seed oil's essentially gone to zero.

Cool. Ben, I know that we're running up against the end of the show because you've got an appointment coming up here. And I just want to thank you for your willingness to go against the mainstream in academia and to do it with data and science and to not be pissed off all the time about it. It's easy to get angry. You could tell, you have this playful curiosity, but this is how it works. And I love your vibe, I love your knowledge and just keep doing what you're doing. Thank you. You're@Benbeekman.com, your book is how to Not Get Sick or How to not to Get Sick. What is your YouTube channel.

Yeah. So you mentioned the first source. Please, guys, go to my website. It's just bend and B I K m a n dot com. But yeah, my YouTube is Ben Bickman and then all my social media is just Ben Bickman, PhD. But yeah, I mean, all of this is just my own effort to. As much as I'm an academic and I love it, but I also hate the constraints placed on it where no one's going to read my peer reviewed journal articles. And why would they? So I wanted to have a way to just share the fundamental research with people in a kind of digestible way. And that's always been my hope.

Well, you're doing a great job. Keep it up and you're always welcome to come back on the show.

Thanks, Dave. It's been a pleasure.

See you next time on the Human Upgrade podcast.

If you will. You know, as the body starts to wake back up and get alert, but also insulin can start to climb in response to that glucose climb. And so morning is one of the worst times, but it's the most convenient because we're fasting overnight. We need a fasting state. If in an ideal world we wouldn't measure fasted blood levels until, you know, late morning or early afternoon to let that pass, can. Yeah.

Can you adjust for that? Like, let's say you, you do your insulin test in the morning and it's. Should you just subtract a point off of the morning score to get a more accurate.

I don't know. I don't know. That's a really, really good question. That's never been labored.

This is. This is.

Yeah, you'd want to. I mean, what you'd want to do is take that same person, measure their morning, and then measure their afternoon consistently across a group of people and then find out that, okay, here was morning, giving us a little bit of that false positive range or a false concern. Here was afternoon. So if we make this kind of algorithmic adjustment, it allows us to get the morning, which is the easiest time to do it. Everyone wants to do their fasted tests in the morning so they can end their fast. I get it. But yeah, it would be nice to be able to kind of have an adjustment on hand to say, okay, well, actually it came in at 15 microunits per mil, but based on what we see across the population, if we were to measure this four hours later, it would have come back down to seven. Okay, so you're actually doing great. Yeah, that's never been done.

Wow. Well, this seems like something your lab would be uniquely suited to do.

Yeah, we should, I hope for that.

We've talked about doing squats after a meal or going for a walk to lower blood sugar, which ought to also lower blood insulin. We hope. Are there other non dietary things we can do? Biohacks like red light therapy, pulsed electromagnetics, cold plunges. What do those do?

Yes. So the only one I can speak to is some authority is cold plunge. Although I think everything you've just mentioned does help, including just sauna. It's the interesting quirk of just temperature extremes with cold immersion. Yeah, I mean the results are really remarkable across the board and I am an unapologetic advocate of cold immersion. But there is something to be said for there are two mechanisms that cold therapy will engage. One which is shivering, induced thermogenesis and then it's mitochondrial uncoupling.

Yes.

And the brown fat being the most famous example of that. But with the shivering, of course, the whole body, contraction of the muscles, that's really, I mean you are exercising, you are contracting and relaxing muscles in order to generate heat. Well, that heat has to come from burning something and a lot of that something's going to be glucose. Now at the same time you're shivering, you're also sending a signal to mitochondria, particularly in fat tissue, that hey, mitochondria and fat tissue, I need you to become less efficient, which, which is to say I need you to burn energy to create heat because heat is a waste product, you know, and, but when the body gets cold, it actually gets a little, well, wasteful. It starts to want to burn energy just to create more heat. And so you have this uncoupling where the mitochondria, it's basically like you're, you're, you're revving the engine in your, your car, but you're keeping your foot on the clutch at the same time. And so you're getting a high RPMs, but you're not getting any speed, you're not moving. So you've uncoupled the burning of the fuel in the engine with the movement of the car, you know, which is the, not the same that I mentioned earlier. Earlier I mentioned that ketones help the muscle be more coupled. In that case. Now you're revving the engine and you're seeing movement with the speedometer. But with cold and with ketones, generally you're uncoupling it where you're revving the engine but you're not moving anywhere. You've uncoupled Those two actions. And so cold therapy is an incredible way. But there also are kind of other hacks like apple cider vinegar is surprisingly effective. But you were kind of saying non dietary. So. Yeah, of all of those I personally leverage whenever I can take advantage of cold immersion and sauna. They're exceptional in this regard.

I do them a lot. The other thing that I notice has a big effect on my blood glucose stability, which is a proxy for insulin, is darkness at night. So I'll wear the truedark glasses that trick the brain into thinking that it's nighttime. And if I wear these for an hour or so before bed, especially if I'm traveling, I have much more stable blood glucose the next day. And I think just darkness at night to reinforce the rhythm works.

Yeah, well, it does work. Just to put a really clear statement on that. One of the reasons East Asians have such unexpectedly high levels of glucose is because that. But these are cultures that have the highest bright blue light exposure later into the evening. That is one of the reasons. There are some other quirks of physiology across ethnicities, but it is an absolute consistent feature of East Asian culture. Lots of bright blue light into all hours of the night, which absolutely will disrupt circadian rhythm to such a point that you'll have higher cortisol levels the next morning and in turn higher glucose volatility.

Environmental toxins and insulin resistance. Is there a connection?

Oh, for sure, yeah. In fact, in my. My first book, you mentioned my how not to Get Sick, which is this one over my shoulder, One step over outside of the camera is my why we Get Sick book. I actually devoted a small section to, as I talked about the origins of insulin resistance to describe some of the evidence, looking at certain molecules from like plasticizer agents and detergent agents and more and more, even certain pesticides and herbicides.

Yes.

So these are all chemicals that have varying direct or indirect effects at promoting insulin resistance. Where the direct effect is such like lectins have a direct effect as a kind of food anti nutrient toxin. Lectins have a direct effect of causing insulin resistance. Whereas some of the detergent molecules like diethylstilbestrol, it's not going to have as much of a direct effect, but rather an indirect effect by promoting the growth of the fat cell. And when fat that comes back to the kind of slow insulin resistance that I alluded to earlier, where when the fat cell gets too big, it starts to generate its own form of insulin resistance, which just as a interesting aside, it actually starts to promote insulin resistance to try to prevent further growth, but in the process starts to kind of spread that insulin resistance with a couple different signals throughout the body. So, yeah, I mean, what we eat and drink and even, even breathe. We've published papers, working with my colleague, Dr. Paul Reynolds, we just published a paper late last year actually finding this was an animal study where when these animals were exposed to diesel exhaust particles, even when they ate the exact same amount of food as their litter mates, just exposed to normal room air, their fat cells got significantly bigger. So once again, our little rant earlier. Don't tell me it's all about calories. There are these signals, even some things we breathe, that are going to influence the overall dynamic energy storage, the balance of metabolism. So yeah, there are. Unfortunately, we live in a bit of a dirty world and where people are able to mitigate some of these risks. Now, I know that some people feel a little overwhelmed. I still firmly believe macros matter most. If you can just focus on one thing, focus on getting your macronutrients, which.

Is give me the right ratios for macros.

Yeah, well, well, for me it's very simply control carbs. So don't get your carbs from bags and boxes with barcodes as much as you can. Whole fruits and vegetables, depending on your overall scenario. And then it's prioritize protein and don't fear the fat that comes with that protein and just don't fear fat in general. But as a reminder, in nature, all protein comes with fat. There's no exception. So every as much as we love protein, people talk about protein. There's always a little bit part of me that says, and don't forget about the fat that is supposed to come with that protein. The body digests it better. The combination of the two is more anabolic than just the protein alone. So macros matter most and then all these other kind of more micro influences. That's not to say they're irrelevant, they matter. But thankfully, if a person is eating fewer carbohydrates, that is the most offensive macronutrient source. Now you can have like proteins, depending on the source, they can also be somewhat influenced and a little polluted.