Hack Your Neurochemistry with Customized Nootropics with Mr. Noots & Matt Gallant

Dave Asprey talks with Mr. Noots and Matt Gallant about designing nootropic stacks to optimize brain performance. They discuss how to balance neurochemicals, what science says about cognitive enhancers, and how to detoxify while improving focus.
Chapters
Bulletproof radio, a state of high performance. It's one of those things. And I think most people listening can, can understand what you're talking about. Just think about that time you were hungover, right? You woke up and like, oh, well, a very large percentage of people wake up some of the time or most of the time feeling hungover without having had more than a glass of wine the night before. And it's because of what they eat. It's because there's other biological stuff going on. There can be endless reasons. And as someone who had chronic fatigue syndrome and fibromyalgia and toxic mold, and people will diagnose toxic mold as Lyme disease all the time, but it's usually mold derived, all that stuff. One of the reasons I cared so much about cognitive enhancers was that I felt like that most of the time and I needed it. But once I got past that and I can wake up and have no coffee and I'm still dialed in unless I do something wrong. And then just like you, within 20 minutes, if you know what's going on. And Chris, my producers, like, I've had a couple afternoons where, man, I gotta show that, like, I'm not feeling good or I'm recording eight hours of content in one day. But try to teach for eight hours a day. You guys have probably done it. It's hard, right? Well, without cutting my hands or if it doesn't work, but I'm like, oh, I'm off and I'll take some stuff. And then like you said, 20 minutes later, like, you're back in the flow. So you're listening to this, guys. That's entirely possible. And I want you to think about this. If you're having a crappy day, it's actually your fault. It's one thing if, you know, someone broke up with you or you know, you got fired, okay, you're have a crappy day, that's normal. But if you just wake up and you're like, I can't bring it today. You actually can. You just don't know the tools. And I couldn't bring it so much that I spent hundreds of thousands of dollars just, just like you did. You know, where you have to get on top of it, but with tools it's easier. So for me, yeah, I spent a long time making up my own stack. Like a long time, as in 10 plus years. What you guys are doing is you're saying, let's start with what's your typical dominant neurochemistry? Let's build a custom stack based on that. And then let's tweak it every month based on the effects you're getting, which God is such a time saver. So the idea is anyone listening should be able to dial it in. And by the way, it's not exactly cheap, you know, compared to a $20 bottle of, you know, 1980s cognitive enhancer from your favorite podcaster. But I'm just not talking about anyone in particular. But what you're going to find is that if one or two days of the month where you would have been wrecked, you're actually at a 9 out of 10. It's priceless. It's actually priceless. And for me, it was. And I can tell you, I would not have written my books. I would not have FIN Business school, I would not have six companies in my portfolio and be advising dozens more. Upgrade labs wouldn't exist. I wouldn't be CEO of it if it wasn't for this ability, because I have a lot of those days, at least I did. So I just. I want to thank you for making it a shorter window for people to get to where they can feel like themselves again, because that's what stood out for this in a way I haven't seen before.
Yeah, I want to queue Mark up to talk about some of the stacks, because they're just brilliantly designed. So I was working on stacks, and then I met Mark, and I had the feeling, okay, here's a guy that I'll never catch up to. Here's a guy that's. That's just decades beyond where I'm at and probably ever will be in cognitive stack design. And also his background in chemistry, it's the extractions. So when we talk about plants, sometimes you want to eliminate certain things from the plant because they're not helpful. So we can literally achieve in one capsule what some of our competitors can't do with seven. Okay, so I've been playing with Nootropics for a long time, and by the way, Dave, you were a big inspiration in that. And, yeah, sometimes you have to take seven or 12 capsules of other brands and you would feel something. But now, because the extractions are so good and clean and concentrated and then potentiated with the rest of the stack, we can achieve again in one capsule what others can't in many. But there's nine different core blends that all have specific purposes. And, Mark, maybe you can go through those and talk about kind of the design and what they do.
So one of the original things that we discovered early on in doing Nootropic stock development was that people were arriving in the morning. Right. They're waking up in the morning, and like you said, they were in a cloud. Their performance was very low. Hormones were out of whack oftentimes, or they're in a. In a different surge than they need to be. Right. So the first thing was, how do we get the brain so that it's prepped, ready and clean for that? So we developed this, we call it mental reboot. We've got an AM and a PM version. PM version is an oral capsule. And what it does is it takes advantage of the fact that your brain size changes at night when you sleep. And when it does that, it opens up around the capillaries and it flows in cerebral spinal fluid that then detoxes the brain. Right.
So the glymphatic system.
Yeah, exactly right. And then it, you know, it gets rid of it. So that's a. That was a really key thing. So our. The thought was, how do we potentiate that process? How do we accentuate that process so that we can use the body's own natural detoxification process and amplify it? So we did that. And then it also helps to reduce tau and beta amyloid protein buildup as well. So things that lead to permanent cognitive decline. We worked really hard to try to get rid of those. And then in the morning, now you've got this beautiful clean palate to work from. So now you've got a sublingual. It's a little capsule. You tap it upright, pull the top off, pour it into your tongue. Tastes great. And what it does is it does kind of the same thing, but it does this. It provides a baseline level of choline precursors. So your body can actually say, I want to create more choline. I've got this available to me now. What are you going to do with it? And so then you can ping your receptor and say, I want more choline, and you've got it available, but it does a lot of other things as well. There's. There's methyl B12. Right. So methyl methylcobalamin.
Yep.
Just much more available. Right. And. And a couple other compounds that really help that process. And then an extract of. Of the celastrus paniculatus, that is a water extract of that which is. Which is unique in its. In that characteristic that. That dissolves as well. And so that gives you this primary and key nootropic function, so that you've got the choline donor. What happens when you're taking a nootropic and you don't have enough choline in your system is it'll start sucking choline out of the muscle and you'll feel this pain in your neck that turns into a headache. So really important characteristic having the choline donor in there.










