This is a YouTube video titled "How Postbiotics Upgrade Your Mitochondria with Dr. Anurag Singh" featuring a discussion between Dave Asprey and Dr. Anurag Singh recorded in April 2022. The content is a health-focused conversation about the timing and effects of mitophagy supplements, fasting, and anti-aging strategies, with Dave Asprey sharing his personal supplement regimen and insights.
You're listening to the Human Upgrade with Dave Asprey. But I want to know, in fact, several members are asking, what's the best time of day to turn on mitophagy? Because we, we know a lot about circadian timing of vitamins and vitamin D in the morning, magnesium in the morning, and maybe at night, but certainly in the morning. When do I want to do? When do I want to do? Timeline? Is this like during a fast, even though it has some raspberry powder? End of a fast. And morning, night, what's your take?
Yeah, so all our clinical studies are done where we see great health, improvements in muscle strength and mitochondrial health. They're done first thing in the morning. So participants usually take it first thing in the morning in a fasted state just before taking their breakfast. And the idea is that you peak the absorption. If you know the kinetics of absorption of this beautiful molecule is it peaks about six to eight hours after the intake. So it's giving sort of, it's hitting the peak when you're at the peak daily activity in a day. And yeah, fasting is overnight. Fasting is also sort of known to, to be inducing autophagy and mitophagy. So sort of, yeah, take it and amplify with mitopure in the morning.
So during a fast?
Yeah, during a fast it will work. Yeah.
And I think there's what, 10 calories or something in a packet, so it's not enough.
Yeah, it's really nothing. I, I think it's hardly got any sugar, so I think probably, I don't.
Think it's gonna raise insulin in, in any way that would shift mtor. I haven't measured it, but it's such a small amount. So. Yeah, people are saying, wouldn't it break a fast, Guys, it doesn't look like I, I don't think it would, but I haven't measured with one of my glucose meters. I've thrown in my coffee during a fast and seen no, no difference. But I wasn't specifically studying.
That's with the powder. You're gonna, you know, we also have the pills, as you said, you can pop two pills and you would.
Yeah, that won't break a fast with the pills. Um, I, that's what I do now. After I used all the packets that I had, I had like six months worth of packets. And to be really clear, this is one of the superstar anti aging supplements that I plan to be taking daily for a long period of time, just based on the, the strength of the research. And I do about a hundred pills a day, 150 sometimes if I'm traveling. Some of those are because they're large molecules like magnesium or glutathione or something. But definitely this is in my stack. And I'm expecting it to be there for a very long period of time because of my aging goals. So I basically only talk about stuff that I think is worthwhile and that I'd be willing to do.
