How to Get Fitter Cells, Stronger Muscles and a Longer Life with Timeline Nutrition
27 Jun 2022 · 1 min
1:23
In this segment of the Bulletproof Radio interview, the hosts discuss a decade‑long research program on pomegranate and its gut‑derived metabolite urolithin A. They explain how, contrary to expectations that many bioactives might be responsible for pomegranate’s health claims, urolithin A emerged as a potent modulator of mitochondrial function. In the model organism Caenorhabditis elegans, supplementation with urolithin A extended lifespan by roughly 50%, a magnitude that surpasses the well‑known effects of caloric restriction. The speakers note that while direct translation to humans is not guaranteed, the direction of the effect suggests a meaningful boost to mitochondrial health and potentially human longevity.
