Dave Asprey discusses how NRF2 activates your body's detox systems to fight environmental toxins. Sulforaphane, a compound in cruciferous vegetables, triggers these pathways. The conversation covers cellular defense mechanisms and how to strengthen your resilience against toxin exposure.
One of the things that's interesting about NRF2, like you said, if it's higher and it's not because you got poisoned, then when you do get poisoned by pretty much being on an airplane or walking into an office building or smelling that person in Chanel number five or that that kid bathed in perfume because they haven't learned that people don't like that yet. All of those actually are system level insults that go to your liver and your, your kidneys and your cellular detox systems. So if your NRF2 levels are higher, your ability to be more resilient in the face of a toxic insult, even from an endotoxin from just, you know, eating the wrong burrito kind of a thing, like you're systemically going to be more resilient, which correlates with longevity.
That's a great example on. And I think a lot of people don't realize that however many times you've, you've got one of those giant reactive oxygen species storm and made double stand breaks in your DNA is how many times you've, you've recruited all the factors that maintain your genome are recruited over to repair that double stranded break. And you, you're distracting who you're supposed to stay as. You know, your development happens, you get all the genes turned on and off correctly. The rest of your life is forgetting what happened during development.
Yep.
And I mean, there's so many ways to get toxins. You know, you can eat them, breathe them, like you said you can. You know, there's a study in the 2000s when I was coming out of public health school of women who were breastfeeding who had flame retardant in their breast milk.
Oh my gosh, thank you California for forcing that and everything.
Yeah. And so it's. And they got it from sitting on couches that had the flame retardant. And so having the NRF2, so Sulforaphane being the best natural molecule at turning on NRF2, having that NRF2 on, it's the best that helps with phase two detox, basically. And so being able to clear those toxins. One of my favorite studies on detox is out of China, Hopkins was there. And you know, all these municipalities, these big cities, chalk filled with all these pretty horrible. Yeah, you get black snot basically if you walk outside. And so they show just a broccoli sprout beverage taken once you peed out all these like benzenes, you know. And so it, it works fast. And it does, it does clear the toxins.
