https://www.listennotes.com/e/864a861d82d24eeea2f42a88e8b69054

I'm Dave Asprey. That's Dave spelled D-A-I-V-E. And this is your 10-minute weekly upgrade on the biggest stories in biohacking, longevity, and the world of health. Let's go.

Are you ready to plug into the latest science of longevity and human performance? Come to Beyond the Biohacking Conference, where biology, longevity, and consciousness collide in real life. Join us May 27th through 29th, 2026 in Austin, Texas. Experience breakthrough tech, meet world-class experts, and connect with people who are also committed to being the best versions of themselves. Because strong community isn't optional. It's how we live longer. Register now at beyondconference.com. Live longer. Live better. Live Beyond. How many nights have you stared at the ceiling, counting the hours until morning? Maybe you tried a sleep supplement, but it knocked you out and left you groggy, like you traded one problem for another. Poor sleep doesn't just make you tired, it kills your performance, slows your brain down, and speeds up aging. Killswitch from Switch Supplements solves that problem. It works with your biology instead of against it. It contains 5 gut-friendly, extensively researched ingredients like GABA, magnesium glycinate, and tart cherry extract to help you fall asleep naturally, stay asleep, and wake up clear. And it's in the form of a delicious, sugar-free, no BS hot cocoa drink. Sleep tracking data proves how well it works. People consistently hit 90+ sleep scores and more than doubled their REM sleep in only 3 days with Killswitch. If you're ready for the best sleep of your life, order now at switchsupplements.com and use code Dave for 20% off. If you don't sleep better, you get your money back. Killswitch works with your biology. Your body does the rest.

A company called Elegant Hoopoe just launched a new type of longevity score that combines 56 biomarkers, inflammation, Bluetooth, sleep quality, cortisol, even mitochondrial function, and tracks it over time. They're integrating this with wearables and lab testing, and they're claiming up to 6 years off biological age in 2 months for some early users. That's a bold claim, but the newsworthy part is that we're seeing real-time biological scoring start to move mainstream. This isn't just a clock, it's a behavioral tool. If this catches on, it could reshape how people approach health, not just waiting for disease, but making upgrades based on weekly data. What to watch: Are these scores actually predictive of long-term outcomes? Or just a wellness metric? Will insurance or corporate wellness programs start using them? Are wearables becoming medical-grade or still just self-tracking toys? Hospitals across the US are starting to use AI algorithms to read echocardiograms. That's the ultrasound of your heart. These tools can instantly measure heart chamber size, ejection fraction, valve function, and flag subtle abnormalities before a human would usually catch them. What's exciting is that this is happening now, not years away. Hospitals like Cedars-Sinai and Mayo Clinic are already using AI-assisted analysis to speed up triage and detect heart failure earlier, especially in under-resourced settings. Why it matters: 1 in 4 deaths in the US is still from heart disease. Early detection is critical. With AI helping the read, you get faster decisions without waiting on overbooked cardiologists. This could change how we think about annual physicals, and AI-read echo might become a new standard. McGill University just published a new study on BrainHQ, the digital cognitive training platform, and it goes beyond better memory scores. Participants, mostly seniors, trained 30 minutes a day for 10 weeks, and PET scans showed increased acetylcholine receptor density. That's real neurochemical remodeling, not just a faster reaction time on an app. Acetylcholine is what drives learning, focus, and neuroplasticity. This kind of signal shows that targeted training can literally rewire the brain's chemical systems, even later in life. Takeaway? This isn't gamified distraction. It's legit intervention. If backed by more data, cognitive rehab could look very different in the next 5 to 10 years. The annual HLTH conference just wrapped in Las Vegas, and the biggest buzzword was digital twins. These are virtual models of your biology built from your real-world data that let doctors simulate how your body would respond to a drug, supplement, or workout before you try it. It's still early, but startups like Twin Health and BioTwin are already building these platforms for metabolic disease and chronic conditions. Some are pairing your wearables with lab data and even genomics to make it precise. Why it matters: this moves medicine from reactive to predictive. It could end trial-and-error healthcare. Expect this to show up first in elite sports, concierge medicine, and longevity clinics. Also discussed at HLTH: wearables that measure inflammation and immune activity, tools to track hormone fluctuations in real time, consumer apps starting to integrate with actual medical records, so your doctor sees what your ring or patch is telling you.

What if quantum physics could make your supplements work at a whole new level? Igniton is the only company that quantum charges their clinical-grade supplements, so they work better than the same ingredients without the charge. This isn't some woo-woo idea. This is real physics with real results. University studies show Igniton's Cognition Formula improves memory, attention, and mental performance more than the non-charged version. And their longevity formula supports healthier aging markers like IL-6, CRP, and blood pressure better than the same ingredients without quantum charging. They do this with absolutely no fillers and no stimulants, just clean inputs carrying the same kind of life force energy that ancient cultures called world spirit. Think of what Google and Nvidia do for quantum computing. Igniton does that for your biology. I spent time in their Colorado lab. I saw the tech. I used the supplements. In fact, I believe in it so much that I invested in the company. So if you're serious about living longer and having a brain that works better, this is for you. Go to igniton.com and use code Dave for 15% off your first order. That's igniton.com. Code Dave. Igniton. Born from light. Backed by science.

Modern life keeps your nervous system in overdrive. Most solutions try to change your brain chemistry, but your body also runs on electrical signals and rhythms. Your brain uses electrical waves, your heart beats in patterns, and your nervous system sends signals through tiny pulses. Light and sound are also forms of energy your body can sense. Scientists have studied them for decades, because certain wavelengths and frequencies influence how cells and nerves respond. That's why I use the One device. It combines light and sound in a wearable. It sends gentle signals your body can respond to while you work, meditate, or wind down. Most wearables just track stress. The One device supports your nervous system directly without any Bluetooth or EMFs. People who wear it report sleeping more deeply and feeling calmer, more focused, energized, and grounded. It's wearable frequency support you can use all day long. Learn more at theonedevice.com/dave. Several health systems in the US just began piloting a single vial blood test that screens for multiple conditions. Cancer risk signals, metabolic dysfunction, hormone balance, inflammatory markers, all from one draw. This isn't a future idea. These panels are launching in select clinics now through partnerships with lab companies like Grail and LabCorp. Here's why this matters. Fewer blood draws equals higher compliance, easier to screen healthy people for silent risk. This opens the door for quarterly or even monthly panels without the friction. This could normalize regular performance-based blood work, not just disease diagnostics. It also gives biohackers a better tool to run experiments and track the effects of protocols with less hassle. If you want to apply what's happening in the headlines, here's a simple 5-day experiment. Morning: track your resting heart rate and HRV. Do 5 minutes of breathwork. Midday: Do one 20-minute focused cognitive task. Note how fast your brain locks in. Evening. Walk after your biggest meal and track sleep quality. One day this week, book a lab draw or health scan. Pre-plan what you want to learn. End of week. Look at one signal. Did it move? Why? That's how you get smarter and stronger every week. All right, guys, that is your weekly biohacking roundup. Join me again next Friday for another rundown of the biggest health stories in the news. Enjoy your weekend.

The Human Upgrade, formerly Bulletproof Radio, was created and is hosted by Dave Asprey. The information contained in this podcast is provided for informational purposes only and is not intended for the purposes of diagnosing, treating, curing, or preventing treat any disease. Before using any products referenced on the podcast, consult with your healthcare provider. Carefully read all labels and heed all directions and cautions that accompany the products. Information found or received through the podcast should not be used in place of a consultation or advice from a healthcare provider. If you suspect you have a medical problem or should you have any healthcare questions, please promptly call or see your healthcare provider. This podcast, including Dave Asprey and the producers, disclaim responsibility for any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guests' qualifications or credibility. This podcast may contain paid endorsements and advertisements for products or services. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. This podcast is owned by Bulletproof Media.