Relationship Goals: Your Gut Microbiome and Immune Function with Kiran Krishnan, Ph.D.

Kiran Krishnan explains how five core practices can reduce inflammation and improve gut function without needing to understand every mechanism. Chronic bloating, loose stools, and cramping aren't normal, they signal dysfunction that drives fatigue, sleep problems, skin rashes, and anxiety through the HPA axis. Addressing these early signs prevents progression to serious conditions like Crohn's disease.
Chapters
Bulletproof radio, a state of high performance. So the first thing to understand is it is a complex self managing system. Your whole body is, in fact, the entire planet is one of those things. So that's why when I started this definition, change the environment around you and inside of you to have full control of your own biology. That's the definition of biohacking. So we have wizards of poop, wizards have got bacteria on here, but there's a lot we don't know. So what we're doing here is recognizing that this system is mostly a black box. And as a hacker, a black box is a system. And you don't know what's in there because you're trying to break in. So all you can do is like push on it and send a signal and see what comes out. And eventually you realize if I do these five things, even if I don't know the guts, it'll do what I want it to do. Right, but you don't know which of those five things in combination. But you know if you don't do all five, or maybe you only do four. And this is what biohacking is. So you're massaging and manipulating a system without knowing exactly where and how it's gonna go in order to get the direction that you want. And that's where we are. But we know so much more now than when I was trying to solve this problem. Like, oh, I don't know, there's an environmental component. And I'm eating tons of kale and tons of horrible whole grains because they told me whole foods were good for me. Right? And you're like, okay, let's throw out the obvious stuff that we know is garbage, but everything else, it's okay to not know everything, it's okay to not do everything, but you have to do enough that like, oh, wow, I have the symptoms of less inflammation and a gut that works. Okay, what are those symptoms and how do I measure them?
Yeah, so the biggest things for people is really their daily, you know, kind of how they feel in their digestive system.
Right.
So people have gotten very accustomed to the idea that discomfort in the digestive tract is normal.
Right.
So they're like, ah, I'm fine, I get some bloat, I get a little loose bowel here and there, I get cramping, but that's normal. You know, that's just how my gut has always been. And one of the things that I want people to really understand is that you don't have to feel that way.
Right.
And of course you know, you have one big night, you're going to go out and party and drink and hang out. Yes, you might feel that way. If you travel overseas periodically, you're going to feel that way. But that's not normal to feel that way throughout, throughout your, your existence. Also things like energy levels, ability to sleep, right? Rashes that pop up on your skin, you know, sensitivity to things like your environmental and by allergies, food sensitivities. All of these things are a symptom of all of this dysfunction and inflammation going on in your gut. And one big one is anxiety and lack of stress management, because the gut is really the core of the HPA activation cycle, right? So that's the stress management cycle that we have within the system. So all of these things put together should dictate to you that, okay, something at the core is going wrong. And even though these are some of the things I feel and they're not that severe, this is the same pathology that leads to long term significant issues.
Right?
So you feel it as tiredness, anxiety, and all that way before you feel it as Crohn's disease.
Right?
So that's a, that's the pathway.
But.










