Use Your Own Immune System to Target Toxins

Lou Reese of United Neuroscience describes a platform that trains your immune system to make antibodies against toxic proteins like alpha-synuclein and amyloid-beta, which accumulate in Parkinson's and neurodegeneration. Long-lived people naturally produce these antibodies. A vaccine-style approach could be cheaper and more equitable than current monoclonal antibody drugs.
Chapters
This is a special edition recorded live at the XPRIZE Visioneering Summit. The interview today is going to be profoundly interesting because it is with my friend Lou Reese, who is founder and c somethingo of United Neuroscience. Lou is working on actively hacking our immune response to all sorts of things that you wouldn't think about. Lou, welcome to the show.
Thank you so much for having me, Dave. It's awesome to be here. It's really an honor and it's great to be with you.
How did you get to be where you are? Why do you care so much about this? And why the heck are you qualified to hack some immune systems?
You know, I'm probably not qualified, but our team is. And I believe that the team and the science behind what we're doing is really solid. And I think we've been developing it for 30 plus years and it's really compelling. You know, there are people that are over a hundred that perform exceptionally well, both physically and mentally. And it turns out that a lot of these older high performers have antibodies that their bodies naturally generate against toxins that their bodies are naturally generating. So when you look at the blood of some of these high performers and high performing agers, what you see is that they, they actually have antibodies against alpha synuclein and forms of A beta.
You gotta describe what these are for people who don't know those.
So alpha synuclein is, is a, is a protein that's frequently linked to Parkinson's. A beta is a protein that on its own is, is, is probably quite helpful, probably actually clears bacteria that somehow makes it across the blood brain barrier. However, as you age, just like your skin changes its texture, those A beta molecules change and they glob up. And when they glob up, they form dimers and oligomers and fibrils, which means they're stuck together. And when you got that stuff stuck together, it causes neuronal death because you disrupt the communication between the synapses and neurons and that literally causes the neuronal death. So what we see is in the people that have those antibodies naturally, they don't have that neuronal death, they don't have those consequences, and they don't have those, the, the, the impending diseases. And so, so I think that what we have is, is an opportunity and, and a technology platform really that allows us to specifically alert the body to these targets one at a time. And the body generates, then generates those exact antibodies like my grandfather and these super agers. And it's amazing because then you get the results that those super agers get right, you have an antibody production that is actively clearing only those toxic endogenous proteins, which is really amazing.
What if you turn on an antibody to something useful, like dare I say, cholesterol?
Yes. So the cholesterol is a great example. It's my belief that if you turn on the immune system to something that is a harmful target, there's absolute risk to that. And so that's something that we are so focused on, on avoiding. And that's why we go after primarily targets that are by their very nature toxic and should not be there.
But cholesterol is a substrate for testosterone and cell membranes. It's not toxic.
So with cholesterol, we're not actually going after cholesterol, we're going after PCSK9.
Now what is that compared to cholesterol?
So PCSK9 is a hormone that has been related to the types of cholesterol specifically that lead to coronary events. So there are approved monoclonal antibody drugs that are the next line of treatment in addition or conjunction with statins or on independent of statins. Usually in conjunction though. And you have to go through multiple lines of treatment of statins that might not be effective for you before anyone will agree to pay for the PCSK9 monoclonal antibody. Because the insurers won't pay for it. Nobody's going to pay for it until you've gone through these lines of treatment. By then the damage done to your heart is irrevocable. So at the time that, that's, now, you know, you're on your, you're on your last leg, so to speak, you then can have access to this PCSK9 vaccine. To me, this is, this is immoral. Oh yeah, this is fundamentally wrong. So what it means is it means that we, what we need to do is have every single form of medicine or health available to everyone democratized. And absolutely that is our priority. And so our vaccine technology, and I'm using that word very loosely because it's really a long acting biologic. It's something that's really body dependent. Your body, your immune system is being unlocked and unleashed to target toxins that are generated by that exact immune system. So the most sophisticated machine in the world ever is our immune system and we're really just targeting it at these, these misshapen or these, these, these elements of chronic illness, these toxins. I actually think that some form of immortality is absolutely on the, on the, the offing right now. If you, if you talk with, with Peter Diamandes or if you talk with, with a lot of these future thinkers, these futurists, and these, in these just innovators. The pace of innovation is, is so breakneck right now. And the pace and generation and storage of information is so amazing that I believe that at least our consciousness will survive. Whether or not that means that our physical bodies will be there, I'm unclear on. I think our physical bodies have every chance of living to 150 or 200 years old. And in this lifespan, I think that right now this the the age of unlocking. I think it's the time where we have an opportunity to reverse aging. I think that we have an opportunity to actually. And my friend Martin said this the other day, Martin Rothblatt, who's the CEO of United Therapeutics.
Martin's great.
It's, it's. Biotechnology is technology. And I used to say we put the tech in biotech. They're very similar thoughts. The bottom line is that this is the revolution.
That's a good deal. Lou Reese, United Neuroscience. Do you have a URL? Where can people go to find out more about what you do?
Www.unitedneuroscience.com dude, you just dated yourself.
Who says www in front of a URL right now?
I don't know.
Are you like 107? What's the deal?
Maybe. See, look how well the aging is working.
I totally just giving you a crap. All right, guys, if you just are saying, Dave, you just talked about vaccines and you didn't shit on them. Actually, that's totally true because you know what? I'm not for or against vaccines. I'm not for, against drugs. I'm not for against liquid D diets. I just like to know what liquid the diet's made out of. Because a gasoline diet probably is a bad idea. So use your head, use your thinking. And protein is not good or bad for you. Fat is not good or bad for you. Water is not good or bad for you. And air is not good or bad for you. It's all about the dose, the timing, and what's actually in there. And that's how you control your biology. And this is an example of the kind of cool stuff that's coming down the pipeline that is actually going to change the future in ways you haven't even thought of. Hopefully you enjoyed the show if you did leave a review. And if you don't have a copy of Superhuman yet, you want to know what's happening right now, read Superhuman. It is literally the roadmap for living longer than Mother Nature wants you to Have a great day.










