Dave AspreyCreator of Biohacking, Longevity Expert & 4x NY Times Bestselling Author

What Biohackers Know About mTOR That You Don't?

Name: What Biohackers Know About mTOR That You Don't?
Uploaded: 2025-02-28T15:30:05+00:00
Duration: 1 min 11 s
Channel: Dave Asprey
Description: In this monologue, the speaker explains the mammalian target of rapamycin (mTOR) as a central growth-promoting pathway activated by protein, insulin, and…

28 Feb 2025 · 1 min

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1:11

In this monologue, the speaker explains the mammalian target of rapamycin (mTOR) as a central growth-promoting pathway activated by protein, insulin, and glucose, which supports muscle building but can accelerate cellular aging when over‑stimulated. The speaker describes how fasting reduces nutrient availability, thereby suppressing mTOR activity and shifting cells toward maintenance and repair rather than division. Finally, the speaker discusses the supplement “Mimeo,” clarifying that it does not directly down‑regulate mTOR but instead up‑regulates complementary pathways—namely NAD⁺ synthesis, AMPK activation, and PPAR‑α signaling—that counteract mTOR‑driven growth and are typically dormant during high‑nutrient states.

Chapters

One of my biohacking fetishes is mtor. What is it? What does fasting do for mtor and then what does mimeo do for it? Mammalian target of rapamycin. It's probably one of the primary growth forward pathways in the body, stimulated by protein intake, insulin, glucose levels. So it's very good for muscle building. But the problem is when you overstimulate mtor, you get all of this pro growth pathways, your cells start dividing at a more rapid rate and what that does is ultimately wear your cells out faster. So tour is very highly associated with decreased lifespan. Fasting is you don't have a lot of nutrients that are floating around, so you're not going to be stimulating the mtor, you're going to be stimulating more of these energy conservation. Don't replicate, don't divide. Let's focus on cell maintenance and repair pathways. Mimeo is not really doing anything to MTOR itself, it's just stimulating these other pathways. The NAD cert, the ampinase, the PPAR alpha. We're not an MTOR downregul, we're just up regulating these other pathways that run counter to MTOR and aren't usually activated at the same time.