How AI splits startups into winners and losers | E2322

7 Aug 2026 · 78 min
This Week in Startups

7 Aug 2026 · 78 min

0:00

In this episode of the "How AI splits startups into winners and losers" podcast, hosts Jason Calacanis and Lon Harris discuss how artificial intelligence is reshaping the SaaS landscape, referencing recent earnings and stock‑based compensation debates at companies like Figma, Twilio, and Airbnb, and citing Harmonic.ai data on AI adoption. Sponsor reads for Lightfield, Sentry, and DigitalOcean are interspersed. The show features an interview with Kofi Asante, CEO of Bluecore Energy, who explains the technology, safety, regulation, and logistics of small modular nuclear reactors mounted on barges for powering ports and data centers. The conversation then shifts to a personal weight‑loss segment where Jason, Lon, and guest Jamie talk about GLP‑1 medications (Wegovy pill vs injection), set tiered weight‑loss goals, and announce a $5,000 per‑tier incentive funded by the hosts, while also addressing the difficulty of obtaining insurance coverage for GLP‑1 drugs in the United States. Later, the hosts comment on the upcoming documentary "Predators" and the cultural legacy of the TV show "To Catch a Predator," debating the ethics of dangerous content creation for views. They draw parallels to extreme‑sports figures like Alex Honnold, discuss the allure of risk in media, and joke about AI‑generated images of Jamie as the Punisher. The episode blends market analysis, deep‑tech interview, personal health experimentation, and media criticism, offering listeners insights into AI’s business impact, emerging nuclear tech, and the human side of health and entertainment trends.

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