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In this brief monologue, Dr. David Perlmutter addresses the prevalence of brain fog among people in their 20s to 40s and identifies restorative sleep as the single most impactful intervention. He explains that insufficient sleep leads to brain inflammation, which impairs cognitive function. While acknowledging that exercise, a diet low in ultra‑processed foods, stress reduction, and selective supplements can help, he emphasizes that deep, restorative sleep—particularly the phase that activates the glymphatic system to clear brain waste—is paramount. He advises tracking both sleep duration and quality with wearable devices such as the Oura Ring or Apple Watch to ensure sufficient deep‑sleep time, suggesting that improving sleep will markedly reduce brain fog.

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