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In this March 23, 2020 livestream, Dr. David Perlmutter reviews recent COVID‑19 science and offers practical advice for the public. He begins by summarizing a New England Journal of Medicine study on virus survival on surfaces, emphasizing that packages are low risk after three days but that delivery personnel can be a vector, and he shares his own decontamination routine (Lysol spray, quarantine, Clorox wash). He then explains why flattening the curve is essential to keep ICU capacity and ventilators available, using the hurricane‑preparedness analogy. Next, he discusses the gut microbiome’s possible role in COVID‑19 severity, linking the hygiene hypothesis, inflammation, and coagulopathy, and advises limiting acid‑blocking drugs and NSAIDs, increasing dietary pre‑biotics, and avoiding unnecessary medications. He shifts to home preparedness: taking inventory of supplies, gardening (seeds, herbs, lettuce), and repurposing garage items for future needs. He stresses mental health – staying positive, limiting news, and engaging in low‑stress activities. He highlights lifestyle measures that support immunity: adequate sleep, regular exercise, and time‑restricted fasting (24‑36 h) as a hormetic stressor, with cautions to consult a clinician. He answers audience questions about ibuprofen, interferon‑beta (SNG001), remdesivir, steroids, antihypertensives, and herbal antivirals, providing links to BMJ and other sources. He announces an upcoming interview with Dr. George Tetz on phages and COVID‑19 genetics, and ends with a Longfellow poem. Throughout, he balances scientific citations with actionable home‑based strategies.

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